It's not about the receptors but the signaling (or lack of) from the receptors.
Receptor expression is usually dynamic - chronic stimulation of receptors often results in decreased numbers of receptors, while under- stimulation causes an increase in the number of receptors. Activation of receptors may also cause modification of receptors to a point where even mild stimuli cause substantial responses. Such changes are not necessarily just alterations in numbers of receptors - types and activities of receptors may also change. Over- or under-stimulation of one receptor can also have profound effects on other receptors.
Things that activate CB1 receptors:
1. Endocannabinoids produced by your own body.
2. Synthetic man-made cannabinoids (like some meds)
3. Plant cannabinoids like marijuana.
"up regulation of CB1 is mediated by increased interferon (IFN) signalling in HCV-infected cells."
sydney.edu.au/mbi/PDFs/Shahidi_SEIB%202011.pdf
Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication.
www.ncbi.nlm.nih.gov/pubmed/?term=Endoca...+C+virus+replication.
Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation
www.ncbi.nlm.nih.gov/pmc/articles/PMC4425004/
Recent studies have confirmed the links between the downgrading of cannabinoid receptors in the brain and regular cannabis use. In short, introducing external THC creates changes in the brain. As the body loses CB1 receptors, more THC is needed to create the desired effect.
Cannabis harms the brain. It has a negative impact on dopamine.
www.medscape.com/viewarticle/846094?src=trendmd_pilot&faf=1
High-potency cannabis damages key brain structure
www.medicalnewstoday.com/articles/303279.php
Cannabis use affects processing of emotions.
"Cannabis appears to have a significant impact on the recognition and processing of human emotions like happiness, sadness and anger"
www.medicalnewstoday.com/articles/307249.php