Worldwide, more Hepatitis C patients have been treated with generic medication than the overpriced branded medication.

Over 90% of patients who have treatment will achieve SVR12 and the data has been presented at the International Liver Congress.

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TOPIC: Question for Those Taking Sof (400)/Led (90)

Question for Those Taking Sof (400)/Led (90) 5 months 1 day ago #23215

  • Quinn
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Hi All!

I'm editing my original message to add specifics about the medication.

I just started taking Sofosbuvir (400 mg) & Ledipasvir (90 mg) by Cipla two weeks ago for my Hep C - 1A. I've read stories from others about feeling more energy after taking meds rather quickly, but actually I'm feeling pretty run down and lethargic from my medication. Is this actually quite common, as well? Anyone else have some stories to tell about their experience with Cipla.

I also don't have much appetite.

Thoughts and comments?

Thanks!

Quinn
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Last Edit: 5 months 1 day ago by Quinn. Reason: Clarifying med contents and adding photo
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Question for Those Taking Cipla 5 months 1 day ago #23217

  • Chapel
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Comment no longer needed,
M, 57, Live in Wellington,NZ.
Genotype 1a diagnosed in 2013.
Treating for the first time since October 31 with Buyers Club Sof/Led. Thanks so much guys. Minimal side effects apart from sore throat at the start..
Viral load 5.4m when treatment started, Undetected at 4 weeks, 8 weeks, End of Treatment and 12-weeks post EOT. Yay!
Last Edit: 5 months 20 hours ago by Chapel. Reason: Original post was edited so this no longer needed.
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Question for Those Taking Cipla 5 months 1 day ago #23218

  • Quinn
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Oooops! I should have known that.

I made edits.

Thank you!
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Question for Those Taking Cipla 5 months 17 hours ago #23220

  • Gaj
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Welcome Quinn, :)

Looks like everyone else is in holiday mode. :lol: If you scroll up this page you will find a number of tabs including Search just above your first post. Entering Cipla or Hepcivir in there will bring up many posts mentioning those names although as Chapel mentioned Sof/Led, Sofosbuvir & Ledipasvir or harvoni (generic or original) all contain the same active ingredients so I would expect any side effects will be much the same regardless of the particular brand.

I was on a slightly different treatment due to my genotype but from my experience and talking to and reading about others who were on the same as you the sides do seem to vary from person to person and often vary through treatment with not all getting the sudden improvement that some do. I guess it may also depend a bit on how bad your HCV symptoms were pretreatment too. Yours don't seem too dissimilar to what some others have experienced but please ask if anything is concerning you as I'm sure someone will be able to chime in to advise.

Something that may help is to ensure you remain well hydrated by drinking plenty of water as this seems to reduce some of the sides.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17

And I couldn't wait to get on the road again
On the road again, on the road again!
- with apologies to Willie ;)
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Question for Those Taking Sof (400)/Led (90) 5 months 8 hours ago #23224

  • Chapel
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Hi Quinn, I took generic harvoni from China for my Hep C genotype 1a and I had very few side effects, a bit of flu-like stuff and a little hyper active feeling. My appetite seemed stronger than pre-treatment.
It sounds like your side effects are pretty minor so far but please report any changes so others can comment. These are fantastic drugs compared to the earlier treatments, as you probably know.
M, 57, Live in Wellington,NZ.
Genotype 1a diagnosed in 2013.
Treating for the first time since October 31 with Buyers Club Sof/Led. Thanks so much guys. Minimal side effects apart from sore throat at the start..
Viral load 5.4m when treatment started, Undetected at 4 weeks, 8 weeks, End of Treatment and 12-weeks post EOT. Yay!
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Question for Those Taking Sof (400)/Led (90) 4 months 4 weeks ago #23230

  • coral
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Hi Quinn and Welcome!
I took Sof/Led for the first 12 weeks of my first round of treatment and had very few side effects. In my experience it is sometimes hard to distinguish between the virus symptoms and the treatment in the early days. I definately noticed the difference when the virus had cleared particularly in terms of brain fog and tiredness. I think when we carry this virus for so long it's hard to know what a normal ebb and flow of energy feels like.

As Gaj mentioned it is really important to keep hydrated. I have to consciously make myself drink lots of water - at the moment if I don't I end up with a headaches.

I'm really happy that you have started the treatment. Time goes fast - the treatment will be over and the virus will be gone before you know.

Look forward to seeing your updates #flower #flower
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 UND Hooray...
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Question for Those Taking Sof (400)/Led (90) 4 months 4 weeks ago #23231

  • Tommy
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I have ZERO side effects. Well maybe tons and tons of energy but no negatives. I wasn't sure I had REAL medication until I took my 5 week SVR and came back undetected after having a virus load of well over 3 million. Good luck with everything. Minor side effects is just a short time hurtle to overcome. Well worth it in the long run.
Genotype 1A
ALT 473
AST 226
Virus Load 3,119,030
Results as of May-2016
5 week viral load/undetected as of 12/02/2016
Liver Biopsy Results from Feb 2013
Portal/Periportal chronic inflammation and mild interface hepatitis (Grade 2)
Focal Lobular chronic inflammation (Grade 1)
Portal/Periportal fibrosis (stage 1-2 trichrome and reticulin stains utilized)
Negative Iron stains.
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