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TOPIC: Disturbing 2010 study re: Early menopause/Lack of response

Disturbing 2010 study re: Early menopause/Lack of response 6 months 3 weeks ago #22956

  • AK123
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This study is hugely disheartening, as the pegasys/ribavirin treatment I took for six months immediately stopped my (previously regular) menses and effectively induced menopause. Yes, on top of the other crippling and ongoing side- effects.

I have also read that early menopause has only been linked/triggered in women that relapse or are non-responders to the interferon/ribavirin combo, which is perplexing but did occur in my case.

I am now thinking of extending my current daklinza/sovaldi treatment from 16 to 24 weeks (Genotype 3a). My GGT levels were slightly elevated in my pre-treatment blood test which is mentioned as a concern in this study.

Really p###ed off now. Any thoughts on this?
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Disturbing 2010 study re: Early menopause/Lack of response 6 months 3 weeks ago #22957

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[url=http://http://hepatitiscnewdrugresearch.com/early-menopause-and-response-to-hcv-treatment.html][/url]

This is the link to the study mentioned above.
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Disturbing 2010 study re: Early menopause/Lack of response 6 months 3 weeks ago #23017

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Thanks AK123
Yep same here
First hit of the poison = No more period
Don't know what menopause is like because of peginf riba tx.
How could we know when all we did was vomit lose weight lose our hair get covered in bleeding sores and lose our short term memory and feel suicidal from a toxic poison that we were told would save our lives but destroyed them permanently. I get asked about menopause and I have no idea it I ever had symptoms because of all the other stuff being so very severe. From peginf.
Nice legacy of permanent bone pain too eh? Grrr.
There's more but anyway I'm just living now and the DAAs worked and I am HCV free.
I'm doing life in ten minute bites at a time that's my way of setting small goals and achieving what I need to do, including taking respite at least once a week from my responsibilities.
It's too hard to explain it all isn't it
Sending hugs
Ariel #love
Gen 1a
Peg/inf/riba 2012(!?!) stopped at Week 43 due to potassium level ext. low plus other issues (relapse at week 4 post tx, VL120,000) many secondary niggles eg. adenomas.
pre sof/led VL 240,000 Fibrosc F0
Day 25 VL <30
Day 32 UND
Week 10 UND
EOT UND ALT 11 AST 17 GGT 19
SVR4 UND ALT 10 AST 16 GGT 13
SVR8 UND ALT <9 AST 16 GGT 15
SVR12 UND ALT 14 AST 19 GGT 12 Bili 5
EOT +18 ALT13 AST 20 GGT 9 Bili 5
EOT +21 ALT 11 AST 15
Cured at SVR12
Dysplasia Adenoma removed Aug '16
SVR24 UND ALT 11 AST16
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Disturbing 2010 study re: Early menopause/Lack of response 6 months 3 weeks ago #23021

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So, as this study indicates, women that are in early menopause (whether natural or medically induced-grrrrr) have a much higher risk of non-response to pegylated interferon/ribavirin treatment.

This leads me to ponder whether this demographic would similarly be at a higher rate of non-response or alternatively, relapse, with the current DAA's. Perhaps the hormone imbalance may make it more difficult to eradicate the HCV?

There is a rapid progression of symtoms and disease in post menopausal women too.

I feel that the S/D treatment I am on only appeared to begin working after week 10, and foolishly did not adamantly request the hospital clinic test my viral load at week 4 or 8. I have just had my 12 week blood test done, and although according to the nurse 'there is no evidence to extend beyond 12', I am considering going beyond the extra 4 weeks I purchased from Kingswood Pharmacy.

Any input would be welcome as I grapple with this scenario and continue enjoying my present state of medicated nirvana.
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