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TOPIC: Soy an inducer of CYP3A4 ?

Soy an inducer of CYP3A4 ? 1 year 5 months ago #6948

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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6964

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Hear you on that, Pheonix. And I just found out the supposedly 100% whey protein I've been taking, wasn't :pinch: (soy lecithin, in very small type lol) Only found one brand today which promised NO soy, well fingers crossed.

Few other herbal/supplements too

http://fixhepc.com/forum/drug-interactions/329-herbs-and-liver-safety.html#3028
GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26
Last Edit: 1 year 5 months ago by zhuk.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6968

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I eat a lot of Miso...soy is very different when its fermented.
Normal soy I avoid anyway...it's mostly pretty toxic....but Miso...
Do I need to forgo it on Dac? And Led as well?
I might choose Led if I can still eat Miso.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6969

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Hi FlyingFox, I don't think we can draw definite conclusions yet. I have miso in the fridge too, and I decided not to have it for lunch today. But the link I posted was to a solitary study on rats, and I've only seen the summary page. I've seen soy described as an inhibitor elsewhere, which wouldn't be so bad (if you want to dose up).

I think we need to hear more from the medical and scientific people on the forum...
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6970

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Seems not, fox (speaking tentatively)

Both sofosbuvir and ledipasvir are not metabolized by the cytochrome P450 system of enzymes but rather are substrates for p-glycoprotein.


https://www.ncbi.nlm.nih.gov/pubmed/25553890
GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6973

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Zhuk the concerns about CYP3A4 relate to Daclatasvir.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6974

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Sorry Zhuk didn't notice Flyingfox was talking about Led.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6977

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I haven't started treatment yet so I'm still trying to choose.
Daclatasvir seems to be contraindicated for a few of my favourite things.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #6978

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personally I'm happy to give up lots of favourite things for 12 weeks. But I don't want to convince you either way. Best talk to experts.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #7002

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Hey Flying Fox!!!!

I've been eating miso during 8 months before TX....Fantastic...! I stopped eating Macrobiotics on TX because it wasn't possible anymore...Every tissue in your body will change...so...to me eating healthy was a difficult thing to do because all this years I ate so strict!!.....BUT Miso is full of omega and you should not eat that with TX....I don't know...Miso is such an intestins-cleaner....I don't do it...You will not be able to control your appetite anyways :P :P ....Good luck!flyingfox66 wrote:
I eat a lot of Miso...soy is very different when its fermented.
Normal soy I avoid anyway...it's mostly pretty toxic....but Miso...
Do I need to forgo it on Dac? And Led as well?
I might choose Led if I can still eat Miso.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #7004

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Hey! he TX will take control of your appetite anyways...Once you start TX, a lot of powerful things will be happening on a physical, emotional, spiritual level....With all this happening your body will need more calories and stuff...I've been very disciplined all these years...And on TX: uncontrolable LOL :)Phoenix wrote:
personally I'm happy to give up lots of favourite things for 12 weeks. But I don't want to convince you either way. Best talk to experts.
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #7023

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Interesting...omegas are not good on Tx?
Thats really why I am concerned about Miso...its my probiotic (I use unpasteurised).
Maybe once my digestion comes back on line I won't need it so much.
I'm not hugely strict diet wise, though I always prefer fresh food.
Rich food has made me feel sick for years and years now. Be funny if that changes. I might get fat! :D
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #7024

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I'm battling that myself ff66,

All the foods I couldn't eat previously look, smell and taste delicious now. I use to have to make myself eat at mealtimes to keep condition. Now, I find I want to eat all day!
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17

And I couldn't wait to get on the road again
On the road again, on the road again!
- with apologies to Willie ;)
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #7025

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Ah well hopefully we'll have so much energy we'll be able to run around to burn it all off :)
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Soy an inducer of CYP3A4 ? 1 year 5 months ago #7027

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Well yes, but all that exercise just makes me even hungrier. I am feeling fitter though. :woohoo:
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17

And I couldn't wait to get on the road again
On the road again, on the road again!
- with apologies to Willie ;)
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