You take them by mouth once a day.
They are fast release medications (so can be crushed) and can be taken with or without food, in the morning or night
Many patients prefer night time as any dose associated side effects occur while sleeping. This is probably the best time for generic Harvoni® and generic Epclusa® as stomach acid helps absorbtion and is maximal in the early hours of the morning.
About 1 in 5 patients gets headaches when taking sofosbuvir based medication. These usually settle after the first week. Extra fluid intake (about 1 litre) and ordinary headache tablets like aspirin, paracetamol and ibuprofen all work well and do not interact.