Wednesday, 10 June 2015 06:40

Sofosbuvir Ledipasvir NMR and Mass Spec

We were quite excited to see the first shipment of Chinese sourced Sofosbuvir and Ledipasvir. A white powder and and off white powder, but what would the NMR show? Here's the NMR for Sofosbuvir which is right on the money.

Ledipasvir: mass [M+H] + 889.4195 ( < 2 ppm error)

  • molecular formula - C49H54F2N8O6

Sofosbuvir: mass [M+H] + 530.1699 ( < 0.2 ppm error)

  • molecular formula - C22H29FN3O9P
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On the 20th May 2015 the Medicines and Healthcare products Regulatory Agency in the UK issued a Drug Safety Update titled:

Sofosbuvir with daclatasvir; sofosbuvir and ledipasvir: risks of severe bradycardia and heart block when taken with amiodarone.

You will find a link to it at:

https://www.gov.uk/drug-safety-update/sofosbuvir-with-daclatasvir-sofosbuvir-and-ledipasvir-risks-of-severe-bradycardia-and-heart-block-when-taken-with-amiodarone

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 WHO today published the new edition of its Model List of Essential Medicines which includes ground-breaking new treatments for hepatitis C.

http://www.who.int/mediacentre/news/releases/2015/new-essential-medicines-list/en/ 

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