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compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #941
Thanks! I take thyroxine 0,25 mcg...I guess I'll need to get my thyroid monitored...Can I take it with the meds? I also take 0,25 mg xanax every night because otherwise my liver won't let me sleep all night... Can I still take it on treatment? Sorry, maybe I should take a personal appointment! Thanks!!! | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #945
Life, here is some information from the pharma companies. I am not a doctor so have absolutely no idea about other drug interactions. I don't take any other drugs or supplements so there is no issue for me in that regard. I saw a link somewhere on the forum about interactions but have no idea what forum it was on. 1. If I were you I would very, very seriously consider talking with Dr Freeman or some other healthcare professional. These are powerful drugs and the treatment and possible side effect dangers really depends on your individual situation. A few dollars invested in professional support is an excellent investment. 2. I would also do some in depth research, read and educate myself before starting treating so you are aware of the ramifications of treating yourself with this method. I am far from an expert on the subject but have read tons of reports, studies on the trials, applications for approval to the FDA and their European counterpart, etc,. etc., so feel quite comfortable with self-treatment but I have also found a liver specialist that will support me informally as he cannot support me formally because I am using medicine in a combination that is not yet covered by health insurance in Japan. Getting information on these forums is/can be a good idea but tends to be information from regular people. Though well-meaning and sometimes quite informative, the "advice" on these types of forums cannot/should not replace that which you can get from a professional, unless you have absolutely no way of accessing professional support.. While reading the posts you have probably noticed that basically everyone has some type of professional support. There are many good websites with lots of detailed information regarding diet, etc, etc. www.hcvguidelines.org/full-report-view www.catie.ca/en/hepatitis-c hepc.liverfoundation.org/treatment/while...naging-side-effects/ Hope this helps. Good luck. Gary | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #951
| Totally agree with Gary on that Life, We all have different issues & health specs. Special , ie professional care needs to be taken with other medicines, supplements and even, I have read, some foods. I know StJohns Wart for example should be avoided and some talk of grapefruit & Seville oranges. Susie GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC The following user(s) said Thank You: Life |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #957
Grapefruit is know to interact with many different medicines, and amplify their effect: en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions I found this for Sof: www.uniprix.com/en/drug-lexicon/6649/sovaldi And this for Dac: www.rxwiki.com/daklinza | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #958
I think I've posted this capsule chart before, but it's worth putting it up again: capsuleusa.com/chart And, because our medicine is 'immediate release', don't get the enteric coated (delayed release) ones. The following user(s) said Thank You: Life | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #967
Gary, here is the chart/tool that Dr Freeman posted earlier, just put your tx drugs in and add the others and it will let you know if there are any known issues: www.hep-druginteractions.org/checker Em Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016. | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #968
Thanks, Em. Very interesting website, very detailed. There seems to be lots of useful links/tools on this site but most of it seems to be randomly posted in various forums. It would be great if they could be gathered into one place. Do you think that would be possible or too much energy/effort involved? Regards, Gary | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #969
Gary, I just ordered capsules overhere, size 0, what did you mean about enteric coated. I just bought gelatine capsules... | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #971
I think that question was meant for me? Enteric coated capsules dissolve in the gut. If you bought normal gelatin ones that's fine. They dissolve in the stomach, where this medicine is supposed to be released. The following user(s) said Thank You: Life | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #972
hi guys/girls, I thought if you get the meds via the Buyers Club they will encapsulate & test the meds for you for a small fee, or am I missing something here ? Geno 3, Fibro 8.7 pKA, tx experinced in 2005 - Peg/Riba, relapsed. Started tx 1/12/2015 with Indian Sofo & Chinese Dac. 5 weeks result all normal, ALT 18 - down from ALT 73 at the start of tx. 5 weeks HCV PCR RNA - UND. - down from 2 ML 9 weeks HCV PCR RNA - UND. | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #974
| Hi Jolie, I think, as it stands right now, this is only available if you are in Australia.as legally, the medicines can't be re-sent out of Australia. Please correct me if I'm wrong anyone? But you can have them delivered direct from a manufacturer if this is permitted, so yes, if you do this, they would come in API form and need to be capsulated. Is this right? GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #977
Hi Gary Yeah, the forum sort of took of so fast that I'm sure the IT's didn't have time to categorise things. Having been in and about many other forums I recognised this early in the piece and set up my own place to talk about my own tx experience 'emilio's place' I notice others are doing this as well. We probably need to arrange things into: introductions, treatment, research, new supplies etc. Some of the really good info is way back in the postings, like the tool I forwarded you. Em Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016. The following user(s) said Thank You: Life | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #984
Jolie, as London Girl wrote, most people on the forum are going through the Buyers Club but some of us do not live in Aus or a country that is open to import of these medicines by people for personal use and/or do not have a prescription so we have gotten our meds from other sources (generally Mesochem in the past but it seems other countries are also possibilities now), and are just accessing the forum to gather information so we can treat ourselves, with or without professional support. Also, in the beginning of this I don't think there was a Buyers Club so everyone was ordering the meds themselves as powder. However, the Aus government and the supplier seem to have gotten somewhat stricter about encapsulating/selling to individuals so the Buyers Club was formed as a way to facilitate treatment. Don't quote me on that but I think that is what has happened. As for myself, I live in Tokyo and it is basically impossible to get a prescription from anyone here to source the meds by oneself so I dealt directly with the Chinese company. In that situation, the Buyers Club/Dr Freeman cannot assist with the testing/encapsulating as there must be a prescription connected with the meds. I am not sure about all of the details regarding who can or can't import to which country so you would need to ask someone else if you are interested. Regards, Gary | |
compounding Sofosbivur (& Daclatasvir) by oneself 8 years 6 months ago #1281
Thanks Life. Good luck with the compounding. I will receive my scales on Sunday so will compound next week and start tx from 26th as I have a busy week next week. Take care!! | |