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TOPIC: Sofosburvir + Daclatasvir Worried about KRATOM usage

Sofosburvir + Daclatasvir Worried about KRATOM usage 3 months 3 weeks ago #27913

  • Mar
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Hi Christoffer, welcome to the forum, and congratulations on starting treatment with Epclusa, it's a really great drug :+1: . Regarding the use of Kratom with Epclusa, a previous answer in this thread by Dr James Freeman, FixHepC's founder, states that Kratom should be avoided when treated with Daclatasvir medication, and that "it should be ok, but..." (so maybe best avoided) when treated with Epclusa medication. He also said "I do tell my patients you can’t get problems from drugs you are not taking...". So it's probably wise to avoid it during treatment to eliminate any doubt. It's also worth noting that the patient in this thread also said "I felt so much better after finishing Epclusa I never bothered with kratom again".
Last Edit: 3 months 3 weeks ago by Mar.
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Sofosburvir + Daclatasvir Worried about KRATOM usage 3 months 3 weeks ago #27914

  • lamussa
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Christoffer, stop the kratom now. Dr. James mentioned that kratom might increase levels of one of the active ingredients of Epclusa to toxic levels:
It (kratom) is a potent inhibitor of a number of cytochromes including the CYP3A4 one that metabolised daclatasvir so would be expected to cause daclatasvir toxicity or increased side effects.

Better not to use any herbal supplements while taking Epclusa unless approved by your treating physician.
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