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TOPIC: Eight week treatment

Eight week treatment 3 years 6 months ago #2062

  • Johnboy
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www.natap.org/2015/EACS/EACS_23.htm

Seems to me that eight weeks treatment is not a financial decision after all. These are great results. Virtually 100% (one patient discontinued due to nausea).

I seriously wonder whether Daclatasvir (for G1 at least) would be as good over the short course. It has a higher log kill than Ledipasvir.

Nevertheless..... I will take each and every pill of my twelve week course.

I am "undetectable" at three weeks and am half through my twelve week course.

:)
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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Eight week treatment 3 years 6 months ago #2082

  • Joy
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Fantastic news Johnboy!
NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive.
Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct.
Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. :-)
A thousand thankyous to Dr James and the amazing FixHepC team.
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Eight week treatment 3 years 6 months ago #2084

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Hi JB, We're creating a research category when we get 5, are you happy for me to move this thread into it once I do this? Cheers Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
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Eight week treatment 3 years 6 months ago #2085

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Hey JB and forgot to say congratulations on your 3 week result. Mine was still detectable under 15 but not far off. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
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Eight week treatment 3 years 6 months ago #2094

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Outstanding news johnboy, and congratulations!


Its nothing short of miraculous to read of the success stories posted here,..yeah the stats on paper are impressive but to read of you guys real-world successes, well its amazing tbh

I can only wish everyone here going for treatment the best of luck :)
GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26
Last Edit: 3 years 6 months ago by zhuk.
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Eight week treatment 3 years 6 months ago #2096

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I seriously wonder whether Daclatasvir (for G1 at least) would be as good over the short course. It has a higher log kill than Ledipasvir.

Hopefully some answers to that question will come from the AASLD conference in mid nov.Like you I will continue to take my sof dac riba for at least 12 wks in the meantime.When you look at the size of some of the subcategories in these results the numbers are sometimes
very small.One must remember in trials like this one of the objects is to overcome the obstacle of the absurd costs Big Pharma are demanding.This criteria does not apply to the same extent when using generics.
Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
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Eight week treatment 3 years 4 months ago #6421

  • Geno1b4
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@Johnboy
Great news and cheers to your new life
I've stumbled upon this hepc therapy calculator based on trial results on various genotypes.
Some trials are not big but still one can get a picture of how treatments worked.

hcvsvrpredictor.liverdoc.com/#/HCV
Genotype 1b & 4, F0/A1, failed Peg&Riba TX 2015,
22 Jan. 2016 - Back from Delhi with 12 week Ledifos supply :) Thx to Parag
Started TX on 27.Jan.2016 - AST 41, ALT 59, GGT 39, ALP 74, VL 500.000, Fibroscan 6.8
19. Feb 2016 - ALT 14, AST 14, GGT 19, ALP 107
19. Apr 2016 EOT - Undetected :)
26. Apr 2016 (1 week after EOT) - ALT 14, AST 17, GGT 12, ALP 77
28. Aug 2016 (17 weeks after EOT) - UND, ALT 15, AST 12, GGT 5, ALP 39 :)
Last Edit: 3 years 4 months ago by Geno1b4.
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