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Dan's Twinvir story 8 years 4 months ago #7005
How she quantified 12? Strange please email me the paper photo. Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured | |
Dan's Twinvir story 8 years 4 months ago #7014
This is the actual result paper. It says just present. Gen 1b, F1-F2. Naive. Started Twinvir tx on 2 nd of December 2015 for 12 weeks. Starting VL 400000, Alt 49/AST 44 1 week VL 29, ALT 44/AST 30. 4 weeks VL 12, ALT 33, Platelets 145, all other tests normal. 7 weeks VL Detected, ALT 28, all other normal 8 weeks UND, 12 week UND, 24 week SVR UND | |
Dan's Twinvir story 8 years 3 months ago #7034
| 'Just present' - Does that suggest you are just 'on the line' of detected / undetected ? Either way, 8 more weeks should blast that away Dan I would think? This whole detected / undetected thing is really confusing me I must say, I seemed to have grasped it at one point, but all understanding seems to have sailed away ! Think when my blood test time comes , I'll do what you've done and ask . Keep the faith Dan, you're doing good, I'll be joining you very soon and will probably be asking you stuff before too long ! Warm wishes to you GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
Dan's Twinvir story 8 years 3 months ago #7047
Thanks LG. I hope your parcel arrives tomorrow and good luck for tx. Gen 1b, F1-F2. Naive. Started Twinvir tx on 2 nd of December 2015 for 12 weeks. Starting VL 400000, Alt 49/AST 44 1 week VL 29, ALT 44/AST 30. 4 weeks VL 12, ALT 33, Platelets 145, all other tests normal. 7 weeks VL Detected, ALT 28, all other normal 8 weeks UND, 12 week UND, 24 week SVR UND The following user(s) said Thank You: LondonGirl | |
Dan's Twinvir story 8 years 3 months ago #7128
Dan, here the data of one person that took Harvoni, its still normal to be detected: Started Harvoni 12/08/2014 (12wks) Finished Harvoni 3/1/15 5wk lab detected <15 8wk lab UND EOT lab UND! 12wk post lab UND! 24wk post lab UND! Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured | |
Dan's Twinvir story 8 years 3 months ago #7129
Thanks Enkel Gen 1b, F1-F2. Naive. Started Twinvir tx on 2 nd of December 2015 for 12 weeks. Starting VL 400000, Alt 49/AST 44 1 week VL 29, ALT 44/AST 30. 4 weeks VL 12, ALT 33, Platelets 145, all other tests normal. 7 weeks VL Detected, ALT 28, all other normal 8 weeks UND, 12 week UND, 24 week SVR UND | |
Dan's Twinvir story 8 years 3 months ago #7200
With only 4 weeks down, you're on the verge of undetected Dan...you will be fine GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 | |
Dan's Twinvir story 8 years 3 months ago #7203
Yes I feel the same no need to panic. The real test is 4 weeks EOT AND 12. The rest are just for ones own satisfaction and to see if the meds work but they mean nothing in terms of a cure. Treatment naive F 3/4 Genotype 1 a & b V/L 17 MILLION Started Harvoni 11th Dec 2015 for 12 weeks 4 weeks VL UND 6 WEEKS ALT 32, AST 34 EOT 03/03 2016 ! UND ALT 34, AST 26 04.04.2016 SVR 4 26.05.2016 SVR 12 16.08.2016 SVR 24 | |
Dan's Twinvir story 8 years 3 months ago #7206
What is EOT? Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety. Started Twinvir 12/12/15. Two weeks ALT 17 at 2 weeks Viral Load UND at 2 weeks ALT 13.5 at 7 weeks EOT ALT 10.5 at 15 weeks EOT ALT 13 at 27 weeks EOT, VL UND, Cured | |
Dan's Twinvir story 8 years 3 months ago #7207
EOT = End Of Treatment ie. when you finish your course of meds. M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15. SVR4 at 7Apr16 ALT 22 AST 22 SVR12 at 9Jun16 ALT 23 AST 25 Melbourne, Australia The following user(s) said Thank You: Enkel | |
Dan's Twinvir story 8 years 3 months ago #7242
| If you're at 12 at week 4 there is a possibility you may need to extend treatment I can empathize I was in the same position, I had bloods done at week 10 and am waiting the results I am expecting to have to extend by 12 weeks. I wouldn't get caught up in the detected versus undetected up too week 12 those results can go up and down during treatment. Actually Darbara the gold standard is six months post treatment. Personally, I think there is a lot of miss information about viral loads during treatment and what they mean. Sorry you're having such a tough time Dan it seems to be very hard on you I am confident it will work out. Sob/Dac from Oct 29 2015 Geno 1b Fiberscan 9.9 Pre treatment Fiberscan 7.4 week 10 VL 1.3 million pre treatment Week 2.5 VL 96 Week 5.5 VL 17 Week 10 VL UD SVR 3 UD SVR 16 UD Cured: All liver functions in normal ranges. |
Dan's Twinvir story 8 years 3 months ago #7250
Extend by 12 weeks. Sounds a lot. I'm a bit confused about Viral load. Some people get <15 and they say it is UND. I have 12, which is less than 15, that is not UND. Gen 1b, F1-F2. Naive. Started Twinvir tx on 2 nd of December 2015 for 12 weeks. Starting VL 400000, Alt 49/AST 44 1 week VL 29, ALT 44/AST 30. 4 weeks VL 12, ALT 33, Platelets 145, all other tests normal. 7 weeks VL Detected, ALT 28, all other normal 8 weeks UND, 12 week UND, 24 week SVR UND | |
Dan's Twinvir story 8 years 3 months ago #7253
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Me too Dan, you're not alone GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
Dan's Twinvir story 8 years 3 months ago #7254
| You have to look at this over all okay the testing can only go as low as 12/15 ,between 0-15the virus is so low they can't say for sure hence you're not Undetected. In simple terms the virus is there in very low amounts if there is no virus the test clearly states you don't have the virus any longer. There are two tests one tests as low as 12 the other 15 there is a wide miss understanding about VL and what they mean over all while you're in treatment. Now, most of Geno Type 1 at week 2/4 come back Undetected 99 % will clear the virus with 12 weeks of treatment and at six months post treatment be cured. Look, you're at week 4, test again in 2 weeks and then think about maybe extending with another DAA which is what I'm probably doing. The facts are, VL can go up and down in the 12 weeks of treatment, Gilead don't consider you a failure if at EOT you're a 12 as you can go on to be cured seen as we pay I'm inclined to continue and the medical advice I've being given( If my VL I've taken at week 10 is detected) I continue. But, if at week 8 if you're at a 12 it starts to look like you're treatment resistant therefore its suggested you continue for another 8/12 weeks to give yourself a better chance. Look, I know how you feel, its deflating everyone else is UD why not me, it hard to get your head around, I think its best to be aware you may need to continue. Trust me, I thought this was a sure thing and for the most part it is, some of us take a little longer and act like F4 with worse geno types. Lastly,this is why its advised to have a consultant you can talk too, I'm like you a patient am by no means an expert, I have read the research and spoke with James and my consultant. Its important not to get worry about what anyone else results are and you understand clearly your own results and what they mean too you. It would be great if you could chat to a consultant. Sob/Dac from Oct 29 2015 Geno 1b Fiberscan 9.9 Pre treatment Fiberscan 7.4 week 10 VL 1.3 million pre treatment Week 2.5 VL 96 Week 5.5 VL 17 Week 10 VL UD SVR 3 UD SVR 16 UD Cured: All liver functions in normal ranges. |
Dan's Twinvir story 8 years 3 months ago #7256
The way I understand it, 'Quantitative' testing determines the actual number per ml of bloodborne virus. However, it is only accurate between 12 and 10,000,000. The 'Qualitative' testing is far more accurate, but can only determine present/not present. So you use quantitative to see how you're doing until <12, then do qualitative to see if it goes all the way down to undetected. (zero). Dr. Freeman? This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James The following user(s) said Thank You: LondonGirl | |
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