I have been on Sofosbuvir and Ledipasvir - 2 tablets - for a week now and have noticed no side effects except that my bile reflux has become a lot worst. I have been taking Nexium with the Harvoni and have to take Ursofalk - Ursodeoxychloic acid - twice a day to help with the bile reflux..
It seems to be working to some degree - just don't know how it will affect the potency of the Harvoni - if at all
I still feel very fatigued and wake during the night with burning sensations, heart palpitations and abdomen pain. I would be lucky to get 4 hours sleep a night.
Diagnosed Hep C 2013
Geno Type: 1a
2015 GGT 227 AST 79 ALT 89 Platelets 88
2016 Treatment Generic Harvoni Finished 29 March 2016
GGT 30 AST 19 ALP 67 Platelets 91
Qualitative Test Results April 12
Hepatitis C NAT (NA): Not Detected
P.C.R Test for Hep C 4th July: Negative
I am onto my 9th week of Sof/Led. Only side effect was insomnia which has eased over time. I vaguely remember reading somewhere on the Forum or on the list of medicines that may interact that you shouldn't be take meds for indigestion/reflux too close to the time you take your Sof/Led. I am no expert of course so hopefully someone else can confirm this for you one way or another. I take Pariet for heartburn/indigestion and take it in the morning and my Sof/Led at night around 8.30pm.
Good luck with your treatment. You will find a lot of support on this Forum.
Lives in Bendigo, Victoria
No prior treatment Genotype 1b Fibroscan 0 (only showed a bit of a fatty liver) Diagnosed in February 2015 Currently on my last week of treatment taking led/sof Last LFT normal
Insomnia the only side effect
Undetected at 4 weeks
SVR4 - undetected - all bloods good and GP very happy
SVR12 bloods to be done at end of April 2016
SVR12 - undetected!!!
Hi Stew, great to hear you have started treatment. Are you being supervised by your GP during treatment as these symptoms sound pretty severe?
M, 57, Live in Wellington,NZ.
Genotype 1a diagnosed in 2013.
Treating for the first time since October 31 with Buyers Club Sof/Led. Thanks so much guys. Minimal side effects apart from sore throat at the start..
Viral load 5.4m when treatment started, Undetected at 4 weeks, 8 weeks, End of Treatment and 12-weeks post EOT. Yay!
Enter your Sofosbuvir/Ledipasvir combo then 'next' and select from the alphabetical listing of other drugs. Nexium is listed as Esomeprazole and the other is just listed as Ursodeoxycholic acid. I just ran those through it and there does seem to be some potential (orange) issues in each case (although they appear manageable) that you should discuss with your doctor or the liver clinic. Sorry, on iPad so difficult to post the report.
Hope this helps.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
Hi Stew, I have stomach ulcers which have flared up considerably since commencing treatment, it was manageable after upping my dose of nexium ..then I added in ribavirin and ulcer discomfort became severe, the stomach ulcers just didn't like that stuff at all, I stopped the ribavirin but it's been a struggle getting my ulcers to a pre ribavirin manageable level, I've had to readjust my diet so the foods I'm eating are all low acidic, I had to trundle out a fold up bed and have set it up at a 45 degree angle so the Acid doesn't rise too much when I sleep, anyways I'm on sof/dac but your on harvoni, I know that ledipasvir needs stomach acid, so you should at least be taking the Meds when your nexium dose is at its weakest?, anyways maybe Dr Freeman can advise when exactly you should stagger the DAA's and the nexium. GL 2 U
GT 3, F3, Contracted 1993 Tx Naive
V/L 1,267,000 AST 67 ALT 65 6/10/15
commence Sof/Dac (Mesochem) 6/11/15
AST ALT normal 24/11 *
*V/L UNDETECTED 24/11*
Congratulations from up north.
We are both Greg and James success stories.
What makes fixhepc different than all those "other" forums, is that the waiting here is generally for the medicine to arrive.
That is how it should be.
Geno 1a, F1, tx naive, had it 35 yrs.
Started Cipla HepcvirL on 12/01/16
Starting VL 490,000
At 16 days in <15
4 week results: UND
8 week results: UND
5 weeks EOT alt 25
SVR 15 - Not Detected
6 months EOT - Not Detected
Hi Stew welcome to the forum another Westy like me. I hope it all goes well for you on treatment and if you have any issues don't hesitate to ask here but for the most part treatment on the orals is relatively smooth sailing.
Enjoy the ride.
Two time relapser.
SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated