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Soy an inducer of CYP3A4 ? 8 years 3 months ago #7028
Would love to hear from someone knowledgeable about CYP3A4 and soy. Is the research I linked to reliable and relevant for our purposes? Is soy an inducer of CYP3A4? If so, is it a strong inducer? BTW just got up at 6am and I'm feeling fine. Not unheard of, but not usual for me... The following user(s) said Thank You: zhuk | |
Soy an inducer of CYP3A4 ? 8 years 3 months ago #7196
With you on that Pheonix, something definitive...but ditching it just in case seemed the wisest move. What about omega? I hadn't read anything that would contraindicate fish oil, for example (have been taking it daily as I usually do) Apologies for my late showing here guys , dodgy net connection was playing up with the recent rain/monsoon lol Edit: Right, now I'm confused...two contradictory links for omega-3 (Although possibly the webmd link is concermed with all those substances taken together, I'm not sure) www.drugs.com/drug-interactions/daclatas...44-0-1749-14959.html www.webmd.com/drugs/2/drug-152082/folic-...9/dmtitle-potent-cyp GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 | |
Soy an inducer of CYP3A4 ? 8 years 3 months ago #7208
Only found the following wiki quote on EPA (Omega 3) as a cyp3a4 inhibitor. "EPA has an inhibitory effect on CYP2C9 and CYP2C19 hepatic enzymes. At a high dose, it may also inhibit the activity of CYP2D6 and CYP3A4, important enzymes involved in drug metabolism.[13]" So don't take too much and don't have within a few hours of Dac. Or eat a nice bit of Tassie Salmon instead.......omega 3, B12, D3, protein and many other essentials in a yummy meal. Warning: the above should not be taken as medical advice but may be viewed as considered anglers opinion. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
Soy an inducer of CYP3A4 ? 8 years 3 months ago #7215
Cheers GAJ Well I habitually take 3000 mg/day, usually a couple of hours after the dac...but not from tomorrow lol Hopefully it hasn't done too much harm, as its only been one week. Fingers crossed And I am a semi 'recovering vegetarian' lol so salmon could well be on the cards GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 | |
Soy an inducer of CYP3A4 ? 7 years 1 month ago #24019
well searching about i found some studies about soy (it's also about ginseng but that was not the related topic www.ncbi.nlm.nih.gov/pubmed/12817527
then medicinalplants.us/herb-drug-interactions-soya About Soy fermented natto ( different from miso ..)
The following user(s) said Thank You: Mnem | |
Soy an inducer of CYP3A4 ? 7 years 1 month ago #24020
. G2, infected maybe in 1971? Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's. Treatment naive. Fibroscan & bloods all normal ranges. Viral load 7million, began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24 Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage. Kia kaha e hoa ma! | |
Soy an inducer of CYP3A4 ? 7 years 1 month ago #24021
Hi Ratus, This may be another example of the old idea that so long as you eat a variety of foods each day, and over the course of weeks and months, that makes it hard to eat or drink too much of any single food constituent. The table in here http://www.ars.usda.gov/nutrientdata shows soy isoflavone levels in different foods G2, infected maybe in 1971? Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's. Treatment naive. Fibroscan & bloods all normal ranges. Viral load 7million, began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24 Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage. Kia kaha e hoa ma! | |
Soy an inducer of CYP3A4 ? 7 years 1 month ago #24026
I've had stomach problems for last several years. Nothing serious, just acid, burning etc. Had to take stuff to relieve every other day almost. kept Walmart up buying Rolaids, Mylanta and such\. About two weeks into Tx stomach problems got better fast. after three weeks, hardly any at all. I had been told it was Hepc related, and I'm hoping it was. I feel better overall now 4th week of Tx. Only sides is low energy, but seems to be getting better each day. I don't eat any of the stuff y'all are talking about, but i do try to eat healthy. happi The following user(s) said Thank You: Paul-Jarman-facebook, Gaj | |
Soy an inducer of CYP3A4 ? 7 years 1 month ago #24028
So the worst case would be higher levels of Daclatasvir. More sides, but no increased risk of treatment failure. A good varied diet - not eating the same stuff day after day - is a good way to avoid interactions (known or unknown) as well as being a pretty good way to eat. YMMV The following user(s) said Thank You: Paul-Jarman-facebook | |
Soy an inducer of CYP3A4 ? 7 years 1 month ago #24029
one point is the succes of the treatment seems not different by country some people eats/drinks a lot of inducers (coffee,green tea,soy,etc.. some others inhibitors like furocoumarins that furocoumarins are found in large quantities in many fruits and vegetables such as parsley, celery, dill, carrot, chervil, fennel, coriander, cumin, lime, pomelo, bitter orange, bergamot, mandarin , Lemon and many others so same conclusion i agree and i think maybe it's better to take treatment with a light dinner (i mean light in furocoumarin,omega 3 ,...etc) | |
Soy an inducer of CYP3A4 ? 7 years 1 month ago #24030
i was reading that i found interesting (not directly concern HepC but a lot of interested point about CYP 3A4) for exemple
home.earthlink.net/~ckaniklidis/interactions.htm#DrugHerb | |
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