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Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #19872
Yep, G3 is a few percent down but the new DAAs look to be lifting us back up there based on the trial data. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #19873
Hi Price, Low carb diet, fats for energy, lots of greens. Got it! Thanks. Good link too. ......coconut oil? ugh! G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The following user(s) said Thank You: fitz | |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #19874
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Thanks Price, yes, definitely more protein, but even with that it's hard to keep the weight on. Initially put some deperately needed kgs on with starting treatment, but still low. I had a LiverMultiScan and it showed no fat (unsurprising!) - but I do feel cholesterol profiles are relevant in some way and feel there are central areas of liver where DAAs had a harder time reaching on me, fat or no fat. What is the cause? LMS showed more intense fibrosis in this area center ribs and where that area has more blood flow? It's a complex issue for sure, things not working right, gaining too much fat, losing too much weight, low Absorption and I guess High Absorption too (although I'm sure not the correct term!) I have read quite a bit on this in the past and instinct telks me this area needs to be looked at more in regard to pre treatment testing. My cholesterol profile wasn't measured by hospital, it was a private blood test. Somehow I think there are some links between how our bodies are responding to the medicines, especially if a slower response, maybe cross GT and Steatosis / Congestion and such areas. I wouldn't even begin to understand this complex thing, but I have learned we are all unique and 'one size' doesn't fit all. This is the big problem with NHS England eg One set route for all, thankfully their narrow option was not a path I took. ie the option of 8 weeks Harvoni, not that I was actually offered that, but it would have been likely as they took fibroscans from the right side flank, not near the center where my fibrosis readings are higher. One thing I feel for sure is exercise is key for all if able, swimming in particular good for those with joint pain. ps on starting treatment I had a huge craving for carbs. ppsSorry to digress somewhat from the GT3 thread, but I do think there may some issues in common that are not GT3 specific although less apparent in GT1s, especially GT1as GT1a Dec14 F2/8.7 VL 900000-2.5M Jan16 Hepcivir-L MonkMed/Redemption Baseline: VL 913575 Alt 76 Platelets low Wk2 VL1157 Alt 23 DET Wk 8 VL 32 Alt19 'In the slow lane' June16 Fibro 5.7 F0/1 LIF 1.5 Wk 11 VL<12 Alt 13 Det/Unq Extending tx 12 wks Mylan Sofo/Dac MonkMed Wk 14 VL <12 Det/Unq Wk 16 VL UNDETECTED Wk 22 + 4 Wks Sunprevir FixHepC Wk 24 UNDETECTED Alt 13 Wk 12 post tx SVR12 Wk 26 SVR24 Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #19878
Hi Gaj it was only last night that I started catching up with this thread. Until then I had no idea you had relapsed. Big hug from Brazil! Blood transfusion in 1992 - Diagnosed in 2007 Tx naive -G1b - F1 VL 2.270.000 ALT 40 Start tx June 4th/2016 with DAAs - Sof/Led from India Bloods on two weeks of tx (June 18th) AST 17 - ALT 10 - GGT 19 Virus UND Bloods on six weeks of tx (July 16th) AST 17 - ALT 8 - GGT 12 Virus UND EOT on August 8th (did 9 weeks and 3 days) SVR 4 Virus UND (September 7th) AST 13 - ALT 5 SVR 14 Virus UND (November 12th) | |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #19880
Hi GAJ, not been on for ages, came on to catch up with people's SVR s and was very sorry to read your news. By now you will be acclimatised to it and getting on with things. Meg has written such a lovely post there, and totally agree, the DAAs have given your liver a break and with your healthy living plan until you re-treat - you will get there! Lots of Debs X Geno 1a, F1, tx naive, had it 35 yrs. Started Cipla HepcvirL on 12/01/16 Starting VL 490,000 At 16 days in <15 4 week results: UND 8 week results: UND 5 weeks EOT alt 25 SVR 15 - Not Detected 6 months EOT - Not Detected | |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20064
| here is a link about the studies being made for SOF+VEL when treating for GT3 and GT2 patients. To be noted that GT3 success rate is increased, at 95% (ASTRAL-3 Trial). www.nejm.org/doi/full/10.1056/NEJMoa1512612#t=article Cheers, RHF In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”. HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic. By sharing this Youtube video you might save someone’s life! My TX: HEPCVIR-L[generic Harvoni]-India SVR52 achieved |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20065
Thanks RHF, with the slight caution that the 95% SVR is the overall result for all G3s. Previously relapsed patients and those with cirrhosis don't quite acheive that level. But it does look like a promising option. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20174
| Well that sucks Gaj and Splitdog, I know exactly how you guys feel being in the same boat myself and 4 1/2 months into re treatment. I have a fatty liver confirmed by ultrasound which probably contributed to the relapse. Now thinking how do we get the meds into the fatty deposits. I take regular asprin and hoped that may do the trick or do we need a higher dose of meds. Maybe it's that E thing that needs looking at , you know excercise i'm allergic to it I'm happy to take the DAA's for a year if needed as i'm feeling well again on tx, any thoughts. cheers Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20175
Hi Paul and fellow posters I'm G1a and waiting on SVR12 (hopefully). Here goes Everyone is different and we have to find what works for us once we get rid of the gift that keeps on giving (and WE ALL WILL!!!) I worry about the strict protein diet on many levels, the first being ethics. I wonder how sustainable a high protein, low carb diet is for our bodies in the long term. A few years ago I joined a personal training gym and adopted their way of eating, did weights and lots of hard cardio (this was post diagnosis - I'd started getting acupuncture and it made me feel well enough to be able to consider this). Getting fit made me feel very good but I noticed my cholesterol levels went up a bit. I lost lots of fat and put on some muscle and looked pretty good. I thought I'd killed the fat kid that lives in my body. But no I think that way of eating is unsustainable on many levels - the impact it has on the planet, our bodies and our wallets, not to mention the animals who suffer in brutal conditions and die horribly to put food on our plates. I don't know the answer to the food question or the exercise question. But I do know that if you don't use it you lose it and it's important to find some activity we enjoy be it walking, swimming, Yoga, lawn bowls or whatever. I am fortunate in that I have activities that I love and are good for me but unfortunately they aren't enough to keep the weight off at a level I would like. (Can't do impact cardio any more due to low back injury). The fact that I don't have a fatty liver (well, no one has mentioned it) is more good luck than good management. Genotype 1a Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!! Harvoni treatment, started 19 March 2016 4 week results Bilirubin 12 down from 14 pre treatment, Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47, VL <15 down from a lazy 6 million or so EOT Results Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND 12 Weeks post EOT Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND Cured baby The following user(s) said Thank You: LondonGirl, Paul-Jarman-facebook, Ariel, Gaj, MtGoat, Matt-Kenney-google, fitz | |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20176
| Velpatasvir & Sofosbuvir (Epclusa) generic now available from Beacon Pharmaceuticals of Bangladesh www.sofosvel.com The new generic that is 95%+ cure for all genotypes, not just gen 1 Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20178
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I hope it comes in 28 pill packs not the 6 pill pictured. Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV The following user(s) said Thank You: fitz |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20179
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So no carbs, more greens and animal fats/protein ? Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV The following user(s) said Thank You: Gaj |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20180
Hey Gaj Having had a mini break I haven't written a whole lot lately and sorry I haven't written personally to you yet. Relapse is no friend of ANYONES that's for sure and I send you big empathy on that. However I'm certain that if anyone can finish this race it's you You're always keeping ahead of the latest data and treatment options to the point you help others with information re same. The recent treatment has given your liver a good break and yes you have a healthy lifestyle too. Another fork in the road, but one with new improved meds coming. You deserve the best Gaj and I am backing you for the next tx. Splashes of hope and wellness Ariel Gen 1a Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas. pre sof/led VL 240,000 Fibsc F0 Day 25 <30 Day 32 UND Week 10 UND EOT UND ALT11AST17GGT19 SVR4 UND ALT10 AST16 GGT13 SVR8 UND ALT <9 AST16 GGT15 SVR12 UND ALT14 AST19 GGT12 Bili 5 EOT +18 ALT13 AST20 GGT9 Bili 5 EOT +21 ALT11AST15 Cured SVR12 Dysplasia Adenomas RemvdAug '16 SVR24 UND ALT11AST16 ColonoscopyClear Nov17 LumpectomyClear ‘18 LithotripsyCytoscopyBiopsy 4/18 The following user(s) said Thank You: LondonGirl, Gaj, beaches, MtGoat, Matt-Kenney-google, Meg, fitz | |
Hard to treat Gt3 - Another stage of the journey 7 years 9 months ago #20182
| I'm sure that 28 pill bottles will eventually be available; remember these folks will also have competition from India, if you want it now, here it is. If I needed this I would crawl there for 6 dose blisterpacks. Beacon is saving somebody's life, probably more than one. If Hillary gets elected she will pass TPP quickly, this opportunity may evaporate. USA residents are encouraged to move forward quickly Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 |