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Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19713
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2 22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve) 10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India 09/05/16: ALT 34, VL: NOT Detected 17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72 The following user(s) said Thank You: fitz | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19714
Serg wrote: "I can be positive with TTW or hepatitis G viruses by PCR test, for example. But this does not mean that i have a "disease", because such viruses will not cause symptoms for me (like cirrhosis). Analogically, if HCV will not cause symptoms for me - what is the reason to define such situation as a "disease"? Of course, for such proportion of patients, who will develop cirrhosis/extrahepatic manifestations during lifetime - HCV is a disease. But many infected people will not develop symptoms." The circular logic of this argument is counterproductive. Serg, If you don't believe you have a disease, may I ask what benefit or purpose there is to your participation here? Your argument seems to be that the only rationale for treatment, or credible indicator of 'disease' would be if one is actually dying of cirrhosis - which is exactly the operative assumption of Big Phama and Big Insurance for denying treatment to Hep C patients until one is by their definition "sick enough". Frankly, if I were Big Pharma/Big Insurance, your argument would be precisely the one I would be making. Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016 2 Week Results 20 June, 2016 AST 19, ALT 32 4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35 6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15 8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND 12 Week Results 31 August, 2016 LFTs Normal, VL = UND EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4" SVR12, 21 Nov 2016. CURED!!! | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19715
en.m.wikipedia.org/wiki/GB_virus_C It appears that HGV is a benign blood borne virus, at any one time our bodies are host to zillions of such viral/bacterial/fungal life forms. The fact that it has (had) a name similar to several diseases does not make it one. Serg
I have amended your statement/question above to reflect the reality that while chronic HCV is a slow acting disease that doesn't always cause obvious damage, it is still having some sort of impact on the body. LFTs within nominal range that drop on treatment is evidence of that. Errr....Google says that TTW is a computer game that can get infected with the SHuer3 virus??? (Take one subscription to Norton annually. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The following user(s) said Thank You: fitz | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19716
fitz, I have F4 (cirrhosis) - hence, i definitely have a disease.
No, i dont think this way. If treatment is "prophylaxis" of cirrhosis/extrahepatic manifestations - people should have full rights to prevent cirrhosis/extrahepatic manifestations - whether they are sick or not. Rather, semantics of "hcv is a disease in every infected", "everyone must undergo treatment", and "achieve a cure" may be promoted by Big Pharma for maximizing their profit. If we can convince infected people that they are all "sick" - it is much simple to sell him medication with huge prices, than sell prophylactic drugs to healthy people. Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19717
Oh, i am sorry for error - of course, TTV virus, not TTW. Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19718
If i correctly understand, LFTs and PCR are signs, not symptoms. A quote about such things (really, i dont agree with all statements of this relatively old article): (www.news-medical.net/health/Hepatitis-C-...d-possible-harm.aspx) Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19719
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016 2 Week Results 20 June, 2016 AST 19, ALT 32 4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35 6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15 8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND 12 Week Results 31 August, 2016 LFTs Normal, VL = UND EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4" SVR12, 21 Nov 2016. CURED!!! | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19720
Thanks to all involved for moving on with the discussion. Content redacted. Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016 2 Week Results 20 June, 2016 AST 19, ALT 32 4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35 6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15 8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND 12 Week Results 31 August, 2016 LFTs Normal, VL = UND EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4" SVR12, 21 Nov 2016. CURED!!! | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19721
| Getting treated for HCV is a vey individual decision / choice, no matter if it is with DAAs, IF+RIB or any other mixture of substances one may identify as possible cure. So, it is up to everyone to decide in what extent they want to research it and make the own opinion. Me personally I am curious to know how the fibrosis may be reduced without treatment In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”. HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic. By sharing this Youtube video you might save someone’s life! My TX: HEPCVIR-L[generic Harvoni]-India SVR52 achieved The following user(s) said Thank You: fitz |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19722
Here's a current one.... HCV RNA Persists in Liver Explants of Most Patients Awaiting Liver Transplantation Treated With an Interferon-Free Regimen. www.ncbi.nlm.nih.gov/m/pubmed/27373513/# P. | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19723
Serg, I also think that you need to take into consideration whether you treated and failed treatment previously because studies have shown that may impact their health in the future. P. | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19724
fitz, I did not wrote that "Big Pharma dispenses treatment to everyone", please do not ascribe to me such thoughts. I will skip some your "ad hominem" arguments, but i agree that these discussed things about "semantics" may seems like some "offtopic" there... And, anyway, we cannot change current "semantic" in this area. Best wishes, Serg Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19725
Yes, of course. Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19726
Thanks Price, very new article. Although not able to access the full article yet, I see that 85% of them went on to acheive SVR after they had their liver transplant so presumably they became undetected? I wonder if having a compromised immune system prior to transplant was preventing them from clearing the stragglers that the DAAs hadn't affected? G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The following user(s) said Thank You: fitz | |
Reduction of liver fibrosis without antiviral treatment 7 years 11 months ago #19727
Full article is available via sci-hub: dx.doi.org.sci-hub.cc/10.1053/j.gastro.2016.06.025 Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 The following user(s) said Thank You: Gaj | |