emo First dose today, the journey begins....

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5 years 10 months ago #21523

Fantastic!! On the home run now Sven
Wishing you a good EOT and UND to SVR for you
Looking forward to your posts keep us updated on your good news
Happies to you from Ariel #flower #flower


Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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5 years 10 months ago #21548

Hey Sven
#flower Best wishes for EOT. Not long now. It's such a waiting game but everything is reading really 'like' awesome. #duck Let us know!


gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
Last Edit: 5 years 10 months ago by pat1.
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5 years 10 months ago #21552

Sven,
I am
SO
VERY
HAPPY
FOR
YOU!!!

and thanks for your thanks, although your test results are thanks enough!
JOY to the world!!
(ha ha)
m


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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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5 years 10 months ago #21564

Here are the 8 week labs. <15 and said he is very encouraged! ( glucose tested is non fasting so a bit high)
Since I sent his nurse the trials information my Doctor has changed his tone, in fact this is the first time I have recieved a phone call 1 day after testing.
I'm am very happy I must say.
In good health my friends.

Attachments:

Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
Last Edit: 5 years 10 months ago by Sven.
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5 years 10 months ago #21568

I don't know why my doctor would say undetected when it s really <15, which is detected but at the least levels from what I have read.
I'm a bit confused, but still happy it is what it is!
In good health to all


Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
Last Edit: 5 years 10 months ago by Sven.
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5 years 10 months ago #21575

Hey Sven
If your VL is <15 that means it's unquantifiable which means there is some virus there but the amounts are too small to count. Call me Captain Obvious :P
This is Good News especially if your liver functions are normal, which they are.
Why did he say UND? I don't know. Maybe he is anticipating the EOT result. You are on track my brother.


Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
Last Edit: 5 years 10 months ago by beaches. Reason: Typo
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5 years 10 months ago #21579

Hi Sven,

15 iu/ml is the limit that the quantitative test assay the lab used can accurately record rather than necessarily being your result. The printout you have shown us looks like the report from your doctor's surgery which sometimes only reports the <15 number rather than the full lab report indicating detected or undetected. So he is the best person to ask which it is.

There are quite a few posts on the subject in the below section of the forum.

fixhepc.com/forum/viral-load-and-svr.html


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 5 years 10 months ago by Gaj.
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5 years 10 months ago #21583

Hi Sven,
I agree with Gaj and the others. It looks like your results just show the quantative test.
Ask your doc about the qualitative results.
Your looking good at any rate.
m


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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
Last Edit: 5 years 10 months ago by mgalbrai.
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5 years 10 months ago #21587

Your physician may have access to deeper report results than are shown on your printout. This was the case with one of my earlier tests.

At 6 weeks my quantitative analysis showed a viral load of <15 with HCV RNA still detected. This didn't mean there was live virus still present, it just meant they could detect pieces of the exploded (dead) replicons.

By 8 weeks HCV RNA was undetected. They couldn't even detect the genetic debris. I suspect this is the case with your results Sven. To ease your mind about this, you can certainly call your specialists office to confirm, and get copies of the full HCV quantitative analysis report, which in my case was separate from the Complete Metabolic Panel report.

Your printout looks like it might be a summary of both reports, but different labs will report results a bit differently, so this is just a guess on my part.


Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
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5 years 10 months ago #21589

Thank you all for the explanation of the read out.
I will connect with them tomorrow and request an explanation of why the words undetectable were used? It is confusing to hear that and then research what the actual <15 means, which is still present but unquantifiable., dead or alive.

IMO, a determination should be 100% reflective of the tests being taken rather than conjecture that could be different from doctors office to doctors office. With that being said I could be incorrect there as well.
But, All in all I'm happy with my scores both on liver tests and the <15. I'll relay new information tomorrow afternoon/evening.
In good health to all


Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
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5 years 10 months ago #21590

Hi m and Sven,

Qualitative tests just give a Detected or Undetected result. On the other hand Sven's result is definitely quantitative as his report states it as <15. But if it is in the <15 range but detected then it would usually include a statement to that effect per the quote from the Cobas Taqman V2 assay instructions below or alternatively it will state that it is undetected.

Results less than the quantitative range of the assay will be reported
as "HCV RNA detected, less than 15 IU/mL".

Sven's result only gives <15 without also stating whether detected or undetected so is ambiguous but as Fitz says, Sven's doctor will be able to clarify the correct answer in more detail.


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 5 years 10 months ago by Gaj.
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5 years 10 months ago #21592

Regardless, you are on track, Sven.
Your next result will be UND.
If your liver functions have dropped to the normal range and you are feeling noticeably better, the cure is working
That is probably small consolation to a detail focused individual, but take heart.


Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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5 years 10 months ago #21650

Twice I asked, twice they said undetected . I find it strange, but he said if it was detected it would say <15iu detected. I asked why it doesn't say undetected and he said, isn't that obvious. The conversation was very short, but as cordial as I could be after all the delays. Hey maybe Tim was right....he could have been busy for 3 weeks. :)
Thank you all, I am very grateful to be defined undetected as less than 3 months ago there was no hope of me getting any medication and my viral load was in the millions!
In good health my friends


Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
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5 years 10 months ago #21656

Over the last 11 months I've noticed there really doesn't seem much consistency in the way different labs and doctors report these results. :huh:

But being told "undetected" twice by the doctor is the real deal. Happy for you Sven! :+1: Happy for you Sven! :+1:


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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5 years 10 months ago #21661

Hey Sven, looks to me like you've good reason to chill, undetected is undetected, no need to read between the lines :lol:
You can't see me but, I'm jumpin' for joy for you :woohoo:

Attachments:

GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
Last Edit: 5 years 10 months ago by Matt-Kenney-google.
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