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First week of treatment with sofosbuvir and daclatasvir 5 years 9 months ago #23031

I am genotype 3, I have no cirrhosis and I have started my treatment today. What symptoms can I expect the first week of treatment?
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First week of treatment with sofosbuvir and daclatasvir 5 years 9 months ago #23033

Hi Jorge,

You can find some information here
fixhepc.com/forum/daa-side-effects/149-s...bo.html?limitstart=0

Wish you a successful treatment!
Cheers!
Nishkama Karma
Cùng nhau loại bỏ Viêm gan C trên khắp thế giới!
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First week of treatment with sofosbuvir and daclatasvir 5 years 9 months ago #23038

Hi Jorge

I was also geno 3a....just finished 12 weeks of sofosbuvir and daclatasvir on 28th November.... I think everyone reacts differently with the medications.... I had a few headaches, but nothing too bad really....main problem for me was the insomnia which started about a week into my treatment.....fatigue was also a problem ( due to the lack of sleep)..... just try and rest as much as you can.... drink lots of water....hope you have an easy time on your meds....good luck donna :+1:
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First week of treatment with sofosbuvir and daclatasvir 5 years 9 months ago #23269

In 3 days time I will be 4 weeks into my treatment. So far I haven't had any mayor issues or side effects apart from diarrhoea after 3 days into my treatment. As I suffer from gallstones as well, it is very difficult to tell what is caused by A or B, so I cannot help being a little bit confused at the moment. One thing I noticed, and I don't even know if this makes any sense, is that I seem to be fully aware of the fact I am asleep when I go to bed and I'd say I am not as tired as I used to be. In fact, I am not sure I am tired at all. I am used to take occasional naps during the day, but I don't fancy it anymore, and if I do, I don't get any sleep. Also, I don't have any muscle or joint pains anymore and I don't itch as often as I used to, but when I do, it is very mild. However, I am still suffering from occasional tachycardia and stress like symptoms for no apparent reason. The feeling is very similar to being worried (anxiety) but without any apparent worrying factors.
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Last edit: by jorge soler.

First week of treatment with sofosbuvir and daclatasvir 5 years 9 months ago #23270

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Hi Jorge, much of what you say mirrors my experiences of Sof/dac treatment during the first few weeks. Many things that I had put down to aging over the previous 10-20 years improved and I also felt less need for sleep and was more wakeful when I did....but still woke up feeling more refreshed. I also had the 'hyped' feeling at times and as treatment progressed it sometimes felt a bit like a rollercoaster but that did smooth out gradually. I think that removing (or at least suppressing in my case) the virus in our bodies results in some very significant physical and accompanying emotional changes in a very short time frame and we need to make allowances for that. Longer term, many of us see continuing improvements and I feel sure that things like your itchiness will decrease even further or possibly even resolve.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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