TOPIC:

Hello Everybody,

does anyone is aware/knows whether there exist any recent data available about the success rate in reaching SVR12 in correspondence with the level of fibrosis prior the start of the treatment?

I still feel iritated when I hear people around me saying that for F1 or F2 there is no need to start the treatment now.

We all know that the DAAs have a success rate of ~95%, but I would really like be able to tell someone still debating whether to treat now or later something like:
- if you are F0, you have "99%" chances to reach SVR12 in 3 months
- if you are F1, your chances drop to "97%" for a 3 months treatment
- if you wait longer and reach F2, F3, F4, your chances drop to 92-90-....% and you might need to take a longer treatment (especially for F4, perhaps some extension for F3).

The above numbers are just imaginary numbers, to ilustrate my point.

Cheers,
RHF

Yes, there is some data, but not really enough.

There have been over 1 million people treated with DAAs (over 800k in Egypt) and IF we had gathered data from all of them as simple as genotype, fibrosis, treatment drugs and duration, and outcome we would have excellent statistics.

Sadly that has not happened. If you go here:

fixhepc.com/hcv

And put in your data, click calculate, then scroll down and click "Show trials" you will see everything that had been published up until about April this year. Outside of GT1 where the numbers are barely adequate, the numbers are small and statistically not large enough to make definitive statements outside of what you already know.....

Hi I had small amounts of scarring of my liver but a moderately high viral load. The hep c was having a huge effect on my liver and kidney. I took generic epclusa, became undetectable and my liver and kidney began working completely normally in just 4 weeks after beginning treatment.
If my doctor had not started me because I didn't have cirrhosis, my liver and kidney would still be getting significant damage. I don't know how to get data for that. But that is what happened to me.

By The Way I Only Had Hepc For 2 Years. So I had scarring that fast. My insurance almost would not help but my doctor fought for me.