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TOPIC: Need advise for gt4 treatment

Need advise for gt4 treatment 2 years 1 week ago #25502

  • kaju
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Hello,
I am new in the forum.I have genotype4 and I decided to start treatment. My fb is 0 and viral load is 9.000.000
I am waiting for my refresh test results and at the same time I am trying to decide which generic treatments will have high rates on me. I did many researches and honestly it makes me more unstable.
I will be very gratefull if you have any advice for me ? Is anybody have experince for genotype4 ?
Thanks a lot for your helps from now..
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Need advise for gt4 treatment 2 years 1 week ago #25503

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Welcome Kaju, and hello,
You have not stated if you have previously been treated, or that you're treatment-naive. Knowing that can help your doctor decide on length of treatment.

If you paste this exact search term: Hepatitic C Genotype Specific Treatment into the search function on this site, that should take you to a page with Table 6 showing the treatment regimens including for HCVC4. That table uses a traffic-light system so that suitable treatments are in green boxes. The ones that will not fix a particular Hep C genotype are in red boxes.
Ask more questions, the folk here are pretty helpful.
Mnem *)*
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
Last Edit: 2 years 1 week ago by Mnem.
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Need advise for gt4 treatment 2 years 1 week ago #25504

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12 weeks Sofosbuvir + Daclatasvir.

1,000,000 Egyptians have taken this for GT4 and cure is over 95%

Don't let the fact it is the cheapest generic worry you, it is awesome. So awesome I even did a blog post on it that links to an 18,000+ person Egyptian GT4 study. That is the biggest study ever and dedicated to GT4

fixhepc.com/blog/item/99-sofosbuvir-dacl...usa-and-maviret.html
YMMV
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Need advise for gt4 treatment 2 years 1 week ago #25505

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Hi Mnem,
Thank you very much for your reply. I checked and it s helpfull for me .
I am treatment naive.
Hopefully I will start to treatment in soon and will be cured.
Thanks a lot again. Cheers.
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Need advise for gt4 treatment 2 years 1 week ago #25506

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Mr Freeman , thank you for your reply and informations.
I will talk with the my doctor also I have one another question.
My viral load is 9.000.000 1 year ago. And doctor told me viral load is variable in time period and we need to start treatment when it s at the lowest level ?? Should I wait ?
Thank you again for your reply.
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Need advise for gt4 treatment 2 years 1 week ago #25507

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Hi Kaju,
Do not wait for your viral load to change naturally. Once you commence taking the right medication, most of the virus will die in the first week.

Some of us on this forum who are cured, had more virus than you when we commenced treatment, others of us had less to start with. In the end we became Hep C free. It doesn't matter where you start, the important thing is just to get the right drugs and start taking them, and to keep swallowing them until the virus has gone completely.
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
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Need advise for gt4 treatment 2 years 1 week ago #25509

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Hi Mnem,
Thank you very much for your support . I will start treatment as soon as possible. I hope will be hep free after treatment.
Cheers.
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Need advise for gt4 treatment 2 years 1 week ago #25512

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There is no suggestion in any of the guidelines from the experts at AASLD or EASL to "wait for virus level to fluctuate to lowest level" before starting.

Viral load makes no difference to treatment success so the best time to start is today. The next best time is tomorrow.
YMMV
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Need advise for gt4 treatment 2 years 1 week ago #25516

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Mr Freeman,
Thank you for your all support. I will start my treatment, I guess maximum in 2 month. After your advice with clinical values I will talk with my doctor and will ask him for 12 weeks Sof + Dac. I am wondering what is the reasons for decided about correct treatment for different patients. An example our state hospitals give Ombitasvir, Paritaprevir ve Ritonavir ( 12 WEEKS) for gt4 patients. I am not doctor and I am the guy who is just researching from web. Maybe reason is different pacts behind the doors? . Also there is one condition for to get treatment free, ıt is fibross score must be minimum 1. I had my biopsy result 10 month ago and fibros score was 0. I dont want delay my treatment anymore
Thak s a lot for your advices .
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Need advise for gt4 treatment 2 years 5 days ago #25539

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Today I got my refresh test results and it makes me little nervous. My viral load is increasing.

HCV-RNA (Edta) 2017: 17416033 IU/ml

HCV-RNA (Edta) 2016: 9596305 IU/ml

My viral load is too much. Isnt it?
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Need advise for gt4 treatment 2 years 5 days ago #25540

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Hello kaju,

Viral loads fluctuate.

The average is 2-3 million.

There is no correlation between viral load and severity of disease.

There is no correlation between viral load and symptoms and

Cure rate is the same for patients with 10 million and 10 thousand viral loads.

Yes, you have Hep C and treating it is a good idea.

Any viral load over undetected is too much...
YMMV
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Need advise for gt4 treatment 2 years 1 day ago #25542

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Dr Freeman,
Our state hospitals give Ombitasvir, Paritaprevir ve Ritonavir ( 12 WEEKS) for gt4 none cirrhotic patients
Today I talked with my doctor and he told me he would like to go with (Ombitasvir+Paritaprevir+Ritonavir)+ Ribavirin for 12 weeks or harvoni for 12 weeks.

Is it possible to get Ombitasvir, Paritaprevir ve Ritonavir + ribavirin ? Or should I go with harvoni?
I will see another doctor in this week. I want to start treatment asaply but I dont know what must I do.
Lots of questions in my mind :(
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Need advise for gt4 treatment 2 years 1 day ago #25543

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I have Genotype 4acd. I received Harvoni through fixhepC and Monk Med for 12 weeks. Genotype 4 responds very well. I am attaching a screen grab of a slide from Liver Meeting in 2016 that shows the cure rates for LVD/SOF from 3 studies: The Synergy, 95%, Ion-4, 100% and Study 1119, 93%.

Here is a link to a 30 minute video of a panel discussing the treatment of G4.


hosted.medipix.com/scourge/player.html?program=scourge4.mp4
G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
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Need advise for gt4 treatment 2 years 1 day ago #25544

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Is it possible to get Ombitasvir, Paritaprevir ve Ritonavir + ribavirin ? Or should I go with harvoni?

Yes it is possible, but Harvoni or Sovaldi/Daklinza is better (as in more cure and less side effects) and cheaper.

Ombitasvir, Paritaprevir, Ritonovir and Ribavirin is used only because it is cheaper for governments to buy.
YMMV
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Need advise for gt4 treatment 2 years 23 hours ago #25545

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Hi Kaju,
I trust that you will be able to focus on what Dr Freeman advises, because he has more experience with HCV treatment than most doctors have.
It is good to undertake your own investigations to find the most expert guidance. Please do not get confused by having too many conflicting recommendations, just concentrate on the knowledge from the top experts.
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
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