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Hepatitis C and cryoglobulinaemia 7 years 10 months ago #17104
| Thanks to a HepC positive organ donor last year, he is no longer on dialysis and is now getting treatment. Things are looking up - if the hands get well too, life will really be good again. Time will tell. The same hands that go fishing should also be able to wash a few dishes!--MsJoe GT 1b Diagnosed 2014 tx naive alt 309 ast 174 fibrotest 0.73 (f3/f4) acti test 0.93 A3 VL 14,660,000+ (Jan 2016) Started Harvoni 5/16/16 5/31/16 VL 239 |
Hepatitis C and cryoglobulinaemia 7 years 10 months ago #17106
MsJoe, I think I've figured out why he insists you do all the typing. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
Hepatitis C and cryoglobulinaemia 7 years 10 months ago #17137
If i correctly understand, symptomatic cryoglobulinemia (for example, cryoglobulinemic vasculitis with serious damaging of kidneys) due to HCV infection, usually, is an indication for rapid initiation of HCV treatment. Asymptomatic cryoglobulinemia often does not require treatment. Successful HCV treatment may lead to disappearance of cryoglobulinemia in majority of patients. From the other hand, there are some data, that successful HCV treatment itself may cause cryoglobulinemia: (www.ncbi.nlm.nih.gov/pubmed/16416186) So, question seems not well-studied yet... Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 | |
Hepatitis C and cryoglobulinaemia 7 years 10 months ago #17143
Thank you, Serge, for posting that link. This is a perplexing, study. It seems to raise as many questions as it answers. I find it difficult to see how successful treatment of hep c could cure cryo in one group of patients while causing it in another The substance of the report, which the abstract says contains a discussion of possible explanations, lies behind a paywall. Without being able to access the full report it is difficult to know quite what to make of the study results from the abstract alone. The study dates from 2005, before the advent of DAAs, and so inevitably refers to patients who cleared the virus through the old interferon and ribavirin treatment regime. This may be significant. Although I'm not an expert, I believe the old interferon and ribavirin treatment worked in very different ways to the new DAAs. Nevertheless, I agree with you that the topic is under-researched. At least part of the explanation may be that Big Pharma, having no pill to treat cryo, has no reason to spend money researching it. Male Geno 1a F3-4 Tx Naive Contracted early 1970s Diagnosed 2012 Started 12 wks TWINVIR (Sof/Led) on 15 Nov 2015 Pre-treatment VL 1.8 million UND at 8 Dec 2015; UND at 12 Jan 2016 Ended 12 wks TWINVIR on 6 Feb 2016 9 Feb 2016 EOT VL test <15 PCR Negative UND at 3 May 2016 SVR12 The following user(s) said Thank You: fitz | |
Hepatitis C and cryoglobulinaemia 7 years 10 months ago #17146
ETA: Thurl was posting as I was writing this post. It appears we share some of the same insights. It occurs to me that not all HCV treatments are equal in this respect. Some (e.g. Viekira Pak + Ribavirin) are known to damage the liver in the process of attempting to clear the virus, while others are not. I am not a medical person, but suspect that therapies which damage the liver during treatment are probably more likely to leave behind a higher level of Cryoglobulinemia than treatments which demonstrate improved liver function during treatment. Many years ago, I had the experience of going from slightly elevated ALT/AST levels, to astronomically high ALT/AST levels upon Interferon therapy (ALT/AST are now only moderately elevated, but have remained far above tested levels prior to Interferon therapy). The side effects from interferon were so severe, I had to stop six months in. Like many others (~50%) who have lived with this virus for many years, while not being specifically diagnosed with Cryoglobulinemia, I have some of the textbook symptoms. The outward symptoms ( occasional rash, bruising, edema in the lower legs) so far have been mild enough that others don't seem to notice them. However, I have undergone three major surgeries for joint problems that no one else in my family has ever experienced. There is nothing to prove, or disprove that the joint problems I've experienced are related to chronic Hep C infection, but personally.... I strongly suspect that they are. One of the reasons I am opting for genric Sof/Led treatment rather than accepting a cheaper treatment known to cause liver damage, is that at a fibrosis score of F3, I think my liver has endured quite enough. While my insurer, and the physicians held captive by them, seem willing in the interest of saving a little bit of money - and honestly it is not that much - to roll the dice on additional liver damage, major drug interactions, severe side effects, etc., I am not. As I've said in a previous post, I've been there, and done that. I'll know soon enough whether the external and internal symptoms I am experiencing will abate with treatment, and I'll be sharing those experiences with my fellow forum members in future posts. Time to get well! Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016 2 Week Results 20 June, 2016 AST 19, ALT 32 4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35 6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15 8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND 12 Week Results 31 August, 2016 LFTs Normal, VL = UND EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4" SVR12, 21 Nov 2016. CURED!!! | |
Hepatitis C and cryoglobulinaemia 7 years 10 months ago #17151
Full text of study is available via sci-hub - link.springer.com.sci-hub.bz/article/10....2Fs10620-005-3059-x# Probably infected in 1977 2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320 2005-2006 - PegIFN/rib 48 weeks treatment, relapse 2016 - compensated F4, MELD 8-9, ALT 100-160 2018 - compensated F4, MELD 8, ALT 91 | |
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