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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20183

Twinvir used to be only available in 7 pill boxes as well until they changed to 28 day bottles but i'm not complaining just thought it strange that it would be sold like that.

The TPP is dead in the water I think.
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20188

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The small package size relates to buying this weeks medication with this weeks pay which is the reality in a lot of less financially advantaged markets. The idea of buying all your medication in one go is totally out of reach for many people in countries like Bangladesh, so in context the size makes sense. I expect larger pack sizes will appear in due course, but both the production dies, and box work needs to be tooled up.

Beacon favour blister packages over bottles because it is much harder (as in expense) to fake blister packaging. Bottles are relatively easy as the bottles are standard off the shelf so a bottle of fake medication is really only stick a label on it.
YMMV
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20190

Amazing explanation, thank you. So sad that a bottle of pills worth $400 will get bootlegged.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20202

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Paul-Jarman-facebook wrote:

Price wrote: Gaj,


hepatitiscnewdrugresearch.com/fatty-liver-and-hcv.html

Reducing dietary saturated fat is associated with an increase in LDL-receptor abundance (which helps the virus multiply) of magnitude similar to the decrease in serum LDL-cholesterol (which is what happens with geno 3).

So it looks like your new diet will have to include restriction of PUFAs in favor of big fat steaks, and eggs and bacon for breakfast instead of cereal, butter, coconut oil :sick: ....and treat during winter when chol is higher (because of seasonal variations in bile acids). :woohoo:

P


So no carbs, more greens and animal fats/protein ?


Hi Paul,

Thanks for your thoughts. More a case of low carbs and sugar, more greens and use animal fats for most of your energy requirements. Here is a link to a post by Dr James about this sort of thing. fixhepc.com/forum/supplements/566-supple...viral-load.html#7463

In there you will see my post about my diet at the time which I have now modified a bit to reduce my carb/polyunsaturated fatty acid intake and increase saturated fats (but not hydrogenated) for energy. Pizzas are off the menu now.:( But on the bright side, lots of steaks, untrimmed lamb chops :cheer:, bacon n' eggs, butter and goodies like that plus non-starchy vegs. Will have to start working up some Thai style curries with coconut cream but skip the rice accompaniment and add vegs instead. (Read Price's post as cereal being the only bad one in her list) The Hopefulgeranium blogs in Dr James post are an interesting if sometimes heavy read on the subject to give some guidance. Look at limiting the hours when you are allowed to eat too so you are in a fasting mode for longer each day, so no midnight snacks, etc.

But for those fearful about Gaj's arteries please be assured that a) I am following this diet with a little bit of moderation so have just moved the balance further away from carbs and over to saturated fats than I usually would eat. b) It is intended as a HCV treatment diet until I achieve SVR not a lifetime plan. (I love pizza far too much to live out my days so miserably. :lol: )

Regarding fatty liver and fibrosis, etc. any exercise is good but from what I have been reading lately vigorous exercise really helps but make sure your doctor gives the go ahead first. Yeah, I know, not so much fun for us whose natural inclination is to be couch potatoes (joke) but if it helps then so be it! And thinking about this, do you remember member Bloot? From his tales he had often led a dreadful lifestyle for someone with HCV but his liver was in pretty good shape. Well he was also a very keen and active mountain biker so that is starting to make sense to me now.

Hope all that makes sense. Take care and best wishes for your Tx. :+1:
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20212

James-Freeman-facebook wrote: The small package size relates to buying this weeks medication with this weeks pay which is the reality in a lot of less financially advantaged markets. The idea of buying all your medication in one go is totally out of reach for many people in countries like Bangladesh, so in context the size makes sense. I expect larger pack sizes will appear in due course, but both the production dies, and box work needs to be tooled up.

Beacon favour blister packages over bottles because it is much harder (as in expense) to fake blister packaging. Bottles are relatively easy as the bottles are standard off the shelf so a bottle of fake medication is really only stick a label on it.


Makes perfect sense Dr James their target market would probably be in the 3rd world for the most part then I expect .
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20215

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Gaj
Oh dear.
Hard cardio.
Problematic for back issues.
But doable.
Exercise bike.
Yuck.
If that's the biggest of my problems I'm doing ok.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20216

Gaj wrote:
In there you will see my post about my diet at the time which I have now modified a bit to reduce my carb/polyunsaturated fatty acid intake and increase saturated fats (but not hydrogenated) for energy. Pizzas are off the menu now.:( But on the bright side, lots of steaks, untrimmed lamb chops :cheer:, bacon n' eggs, butter and goodies like that plus non-starchy vegs. Will have to start working up some Thai style curries with coconut cream but skip the rice accompaniment and add vegs instead. (Read Price's post as cereal being the only bad one in her list) The Hopefulgeranium blogs in Dr James post are an interesting if sometimes heavy read on the subject to give some guidance. Look at limiting the hours when you are allowed to eat too so you are in a fasting mode for longer each day, so no midnight snacks, etc.



Hope all that makes sense. Take care and best wishes for your Tx. :+1:


It sounds easy but in reality a bit harder especially working odd hours like I do but will manage it. I just showed my wife your post as proof she needs to feed me more protein and less carbs. Steak,Vegies,Eggs,Bacon and Thai curries I can do though next week I will be living on the road and have to rely on roadhouse food.

Actually after 4 1/2 months tx my liver is now feeling pretty good nearly all the time but I expect the virus to come back when I stop.

cheers
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20251

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Hello PJ,
I've just accidentally messed with your karma. I was just fiddling about to see how it worked and clicked on the minus, and it removed a point. Despite clicking twice on the plus, it made no difference. Sorry again.
G3a. Probably infected 40 years ago.
Diagnosed July 2015
7/7/2015: ALP 69, ALT 209, WBC 5.8, VL 40,000. Fibroscan 9.5 Kpa.
Commenced treatment Sof/Dac (Natco Pharma) 24 wks in Feb 16
VL UND @ 4 wks, 12 wks

EOT 6/7/16
SVR 12
SVR 24

PHEW! Thank you so much Dr James, Monkmeds and all at Fixhepc
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20252

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Fixed that for you rightsaidfred. :+1:
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20255

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Hi Paul,

Yeah, being on the road would definitely make it harder, I guess you just need to make the best choices you can and maybe ask for extra veg or salad instead of chips, etc?
I'm certainly not perfect with it either. Invited round to dinner at my sister's the other night and figured I would just ask for a small serve of carbs but we had paella. I considered telling the others that I needed to eat all the seafood and chorizo and they could have the rice....decided I wasn't that brave. :lol:
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20262

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Hi Rightsaidfred
You can only give 1 karma every 6 hours, just in case you didn't know
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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Hard to treat Gt3 - Another stage of the journey 7 years 7 months ago #20354

Hi Gaj

Just got back and for the most part stuck to the plan, no carbsjust protein and veges/salad except for the big breakfast yesterday morning. I can't help it if the put my eggs and mushrooms on the toast I didn't order :)

As for the Paella taking the chorizo and seafood out without the rice would be a criminal act. Its probably my favourite dish.
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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