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TOPIC: EOT- Relapse

EOT- Relapse 3 years 7 months ago #13492

  • Paul-Jarman-facebook
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I got a call from the DR James last week informing me that I flunked my SVR 4 test, the bastard virus is back.

Hopefully I'll have meds on Tuesday to retreat again. Dr James was quick off the mark organising treatment again which I am thankful for.

It didn't come as a complete shock as some of the Hep C symptoms had come back and I was already thinking the worst before I got test results back. The good thing is we now have options and easy access to treatment so I am confident that at some point a SVR will be achieved.


cheers
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
Last Edit: 3 years 7 months ago by Paul-Jarman-facebook. Reason: Speling
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EOT- Relapse 3 years 7 months ago #13493

Hi Paul
sorry to hear your news and I was wondering when I saw you had changed your signature to "having another crack". So good we have options for when this thing happens. What meds and treatment length are you going to do?
SVR 24
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EOT- Relapse 3 years 7 months ago #13494

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Hi Paul,
Sorry to hear mate, but glad to see you've got back on the mule. Was the first Tx just 12 weeks?
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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EOT- Relapse 3 years 7 months ago #13496

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So sorry to read this Paul,. Glad to hear you've got a new plan.
Wishing you the very best with the next fight for freedom and glad you're sorted.
I am extending tx by 12 weeks, so will still be around too.
You're not alone.
lg
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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EOT- Relapse 3 years 7 months ago #13498

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Will be re treating with Sof and Dac and taking the Docs advice from there.

Apparently the GT3 can be a stubborn bastard to treat in some. :dry:
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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EOT- Relapse 3 years 7 months ago #13501

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so sorry to hear that :(

this time, you will be cured stubbornly by dynamic duo of sof/dac.

Jay
hep-c for 20yrs.
GT1a. Started twinvir(sof-led) 05/03/16.
Before tx: VL=1.7mil. AST, ALT in normal range
2nd week of tx: VL <15. AST, ALT in normal range
6th week of tx: VL < 15. AST, ALT in normal range
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EOT- Relapse 3 years 7 months ago #13503

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Bollocks, sorry I can't think of a better word am really sorry to hear this Paul
did you do 12 weeks or 24 I think you were UD from early on too.

I know you're sorted through James its worth mentioning there are many trails on right now
for those who failed DAA treatment I would think you'd get on one if needed.

I know its upsetting,anyone I've read about that has failed has managed too get there with
a different regime. Fingers crossed actually everything crossed for you.
Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
Last Edit: 3 years 7 months ago by Sirchinenge.
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EOT- Relapse 3 years 7 months ago #13506

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You are a bleedin trooper Paul. Bugger this virus. You will get on top of the thing. Thank Gawd we have these meds, Dr J, and these friends all on the team. Guessing you're good to go round two asap, wishing you all the best.
Love from Ariel
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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EOT- Relapse 3 years 7 months ago #13507

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I did 18 weeks, if this was a couple of years ago I would be worried but I know we will eventually get there. I don't have any issues on the DAA's and we are fortunate to have access to meds in this country. I also helps having the expertise of Dr James available. :)
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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EOT- Relapse 3 years 7 months ago #13511

Sorry to hear Paul..I'm sure your next lot of treatment will see the end of this rotten virus....good luck.
Lives in Bendigo, Victoria
No prior treatment Genotype 1b Fibroscan 0 (only showed a bit of a fatty liver) Diagnosed in February 2015 Currently on my last week of treatment taking led/sof Last LFT normal
Insomnia the only side effect
Undetected at 4 weeks
SVR4 - undetected - all bloods good and GP very happy
SVR12 bloods to be done at end of April 2016
SVR12 - undetected!!!
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EOT- Relapse 3 years 7 months ago #13516

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Just gutted reading this Paul, I'd thought the same thing, symptoms reappearing etc, Turns out I was wrong and so far at eot+4 all is good
Good luck on the sof/dac or which ever tx Dr J prescribes, guess it will be 24 weeks this time around,,
Hugs mate, really feeling for you,,
jim
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EOT- Relapse 3 years 7 months ago #13522

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Paul-Jarman-facebook wrote:
It didn't come as a complete shock as some of the Hep C symptoms had come back and I was already thinking the worst before I got test results back.

What was the progression of symptoms that made you suspect what turned out to be an unfortunate relapse? I mean, did you feel better during treatment and then things changed in a particularly noticeable way?

I'm just asking as I'm sure that most people have waves of vitality and enervation, so you must have noticed something out of the ordinary that provoked your suspicion. Maybe there is something for all of us to look out for just in case.
G4, F4, cirrhosis.

Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.

YEAR..... ALT..... AST..... GGT... FERRITIN........................................
2009....... 210..... 215..... 953..... 1400........... (Bad health, stupidity)
2015....... 60....... 45....... 150..... 360............. (Improved diet and health, FixHepC treatment)
2016....... 20....... 24....... 25....... 156............. (SVR 12)
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EOT- Relapse 3 years 7 months ago #13524

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Hi Paul, sorry to read this that this has happened. It's the worry at the back of our minds. Feel for you. However it is good you say that you have no issues with the DAA's, so at least you have no worries about sides. You will get there in the end, wishing you all the very best.
Deb X #flower
Geno 1a, F1, tx naive, had it 35 yrs.
Started Cipla HepcvirL on 12/01/16
Starting VL 490,000
At 16 days in <15
4 week results: UND
8 week results: UND
5 weeks EOT alt 25
SVR 15 - Not Detected
6 months EOT - Not Detected
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EOT- Relapse 3 years 7 months ago #13532

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A.L. wrote:
Paul-Jarman-facebook wrote:
It didn't come as a complete shock as some of the Hep C symptoms had come back and I was already thinking the worst before I got test results back.

What was the progression of symptoms that made you suspect what turned out to be an unfortunate relapse? I mean, did you feel better during treatment and then things changed in a particularly noticeable way?

I'm just asking as I'm sure that most people have waves of vitality and enervation, so you must have noticed something out of the ordinary that provoked your suspicion. Maybe there is something for all of us to look out for just in case.

Good question A.L and I'm glad you asked it. The symptoms that came back were bloating, swollen liver and some mild liver pain which I hadn't had for 3 months. I was on a cruise at EOT and had been putting on weight eating a lot of rich food so I was hoping that it was just my fatty liver playing up. I knew I had a bloods coming up so didn't worry about it.

I knew that not all of us would SVR straight up and it appears that GT-3's are batting about 90% on the DAA's, we'll get there eventually :)

PS; Wife has me on these bloody raw veggie shakes for breakfast now, lost 4 kgs in 3 weeks ;)

cheers
Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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EOT- Relapse 3 years 7 months ago #13575

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So sorry Paul, keep at it, you will get there...little bastards are on the run!
GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"
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