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TOPIC: Low blood cell counts?

Low blood cell counts? 4 years 7 months ago #25359

erica
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Ok this is very different from my first tests before starting tx. Everything that was high a month ago is now in range. So that's awesome. Ferritin was 988 and is now 31, which is CRAZY. But here are the things that WERE in range 4 weeks ago that are now OUT of range.

White blood cell count 3.5 (range 3.8 - 10)
Red blood cell count 3.79 (range 3.8 - 5.1)
Absolute neutrophils 1001 (range 1500 - 7800)

And this is just called "ABNORMAL" in my test result:
HCV RNA Quant <15 iu (detected)
HCV RNA Quant <1.18 log (detected)

In my quick internet search, it looks like it's possible that some DAAs can cause red and white blood cell counts to show as low, but not necessarily mean what they normally mean when low. Don't know if that's true or not. I don't feel bad or anything. It's just a strange test result to me. And the HCV RNA tests show the virus is there, just too low to be detected in a Quant test. So that's good. I prefer exact numbers, but whatever. Compared to 8 million I'm good with that for now.

Anyone else get low red and white blood cell counts mid tx? Is this common?

Gt 4ACD
No treatment of any kind until FixHepC. <3
Tx started Monday, Sept 18, 2017!!!
Pre-tx: Ferritin 988, AFP 30.2, AST 109, ALT 148, VL 8864293
4wk: Ferritin 31, AST 23, ALT 17, VL <1.18 Log (detected)
8wk: Ferritin 8, AST 18, ALT 20, VL <1.18 Log (UND)
12wk EOT: Ferritin 9, AST 18, ALT 19, VL <1.18 Log (STILL UND)

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Low blood cell counts? 4 years 7 months ago #25360

DrJames
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Hi Erica,

Those blood results are all fine and barely out of range. You have been having phlebotomy so it would be unusual if your red cell count was not a little low and your white cells are fine.

You are still detected, as in <15 detected at the 4 week mark which is ok, but not as good as <15 undetected.

This HCV result does have some predictive value about SVR. We found (in a study of n=448) that 23% of patients are still detected at 4 weeks, but these form 44% of the failures. The VA found similarly in a study of n=4365 - for them the 22% still detected formed 50% of the failures. Failure rates are low, but in rough terms a circa 97% pre treatment success rate currently looks like about 93% for you. It's worth noting that 75% of patients still detected at End Of Treatment still SVR.

The consideration at this time is if adding an extra 4 weeks treatment is worth it for the insurance value. At best it adds 3% or so versus a basline of over 90% so on a "% cure per $ spent" basis it is a bad investment but some people see the value in it.

Nothing to panic about, just something to consider. For patients with GT1 there are lots of retreatement option. There are less for GT3 and it responds slower (which is why we suggest 16 weeks Sof/Dac for it).

I'm happy to have a chat with you in person about it via video if you'd like.

YMMV

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Low blood cell counts? 4 years 6 months ago #25361

erica Offline Junior Member Posts: 34 Thank you received: 63 Karma: 1	Thanks Doc. Yeah, I'll make an appointment. That sounds like a good idea.
	Gt 4ACD No treatment of any kind until FixHepC. <3 Tx started Monday, Sept 18, 2017!!! Pre-tx: Ferritin 988, AFP 30.2, AST 109, ALT 148, VL 8864293 4wk: Ferritin 31, AST 23, ALT 17, VL <1.18 Log (detected) 8wk: Ferritin 8, AST 18, ALT 20, VL <1.18 Log (UND) 12wk EOT: Ferritin 9, AST 18, ALT 19, VL <1.18 Log (STILL UND) The administrator has disabled public write access.

Low blood cell counts? 4 years 6 months ago #25364

Greedfighter Offline Platinum Member Posts: 609 Thank you received: 1732 Karma: 21	Great results Erica! You're on track to a cure. Listen and follow all advice given by Dr. Freeman Just saying....I think you already know that you are in good hands.
	Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 The administrator has disabled public write access. The following user(s) said Thank You: DrJames, erica

Low blood cell counts? 4 years 6 months ago #25365

erica
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Thank you, Greedfighter! Yes, I definitely do what the Doc says. I trust him with my life. He's quite amazing.

Gt 4ACD
No treatment of any kind until FixHepC. <3
Tx started Monday, Sept 18, 2017!!!
Pre-tx: Ferritin 988, AFP 30.2, AST 109, ALT 148, VL 8864293
4wk: Ferritin 31, AST 23, ALT 17, VL <1.18 Log (detected)
8wk: Ferritin 8, AST 18, ALT 20, VL <1.18 Log (UND)
12wk EOT: Ferritin 9, AST 18, ALT 19, VL <1.18 Log (STILL UND)

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Low blood cell counts? 4 years 5 months ago #25531

Nelu-Covaci-facebook Offline New Member Posts: 3 Thank you received: 8 Karma: 0	Am aceiași problema și eu .La mine in prima săptămâna analizele de sânge a fost ok alt si ast a scăzut numai la 4 săptămâni celule roși mărite,celulele albe scazute(neutrofilele) iar trombocitelor 240
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Low blood cell counts? 4 years 5 months ago #25534

Mnem
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Too many lives go into the making of just one. - Montale
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Hi Nelu-Covaci-fb, Minunat să citești postarea ta, sper că rezultatele testului de sânge sunt mai bune acum.

G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!

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Low blood cell counts? 4 years 5 months ago #25536

DrJames Offline Platinum Member Posts: 1980 Thank you received: 7261 Karma: 111	Care sunt numerele pentru eritrocite și celule albe?
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Low blood cell counts? 3 years 6 months ago #27320

Nelu-Covaci-facebook
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Pot sa spun ca la 3 luni după terminarea tratamentului toate analizele au ieșit foarte bine și nedectabil .Dupa 6 luni mi-am făcut și ultra sound iar doctorița care mi la făcut mi-a spus ca de la F3 am acum F1 iar restul de analize foarte bine.Vreau sa mai adaug ca nu fumez de 2ani,nu beau alcool și de mâncat mănânc cam tot ce poftesc dar cu limita.Va mulțumesc de informațiile primite

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Low blood cell counts? 3 years 6 months ago #27322

Mar Offline Administrator Posts: 287 Thank you received: 765 Karma: 11	Asta este o veste minunată Nelu, felicitări pentru tratamentul tău și pentru nivelul tău de Fibroză care coboară de la F3 la F1, e minunat
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Low blood cell counts? 3 years 6 months ago #27324

Nelu-Covaci-facebook Offline New Member Posts: 3 Thank you received: 8 Karma: 0	Merci pt mesaj și sper ca toți care fac acest tratament sa scape de virus
	The administrator has disabled public write access. The following user(s) said Thank You: DrJames, Iain, hanknassi, Mar

Low blood cell counts? 3 years 6 months ago #27329

DrJames Offline Platinum Member Posts: 1980 Thank you received: 7261 Karma: 111
	YMMV The administrator has disabled public write access. The following user(s) said Thank You: hanknassi, Mar