Sofosbuvir Ledipasvir NMR and Mass Spec

We were quite excited to see the first shipment of Chinese sourced Sofosbuvir and Ledipasvir. A white powder and and off white powder, but what would the NMR show? Here’s the NMR for Sofosbuvir which is right on the money.

Ledipasvir: mass [M+H] + 889.4195 ( < 2 ppm error)

• molecular formula – C₄₉H₅₄F₂N₈O₆

Sofosbuvir: mass [M+H] + 530.1699 ( < 0.2 ppm error)

• molecular formula – C₂₂H₂₉FN₃O₉P