FDA Safety announcement AbbVie V Pak - FixHepC

This topic has 3 replies, 4 voices, and was last updated 9 years, 5 months ago by Dr James.

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23 October 2015 at 12:08 pm #2665
Alsdad
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- Guardian Angel
@alsdad
There seems to be a ‘Goldrush’ effect taking place amongst Big Pharma at the moment on HepC meds. hmy:
23 October 2015 at 12:39 pm #2666
Sir-Paul-Paul-MJ-twitter
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- Acolyte
@sir-paul-paul-mj-twitter
The AbbVie trials are batting 100% I believe , my brother in law just finishing 27 weeks on it next week his sfx weren’t too bad considering he was quite sick when he started.

Gen 3a Started Sof Dac 16/10/15
V/L 20 Mill +
Hep C pos approx. 27 yrs

Non responder 2011 BMS (dac) Peg Rib
25 October 2015 at 7:06 am #2701
Dr James
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- Guardian Angel
@fixhepc
Most drugs are metabolised by the liver. Even something as routine as Paracetamol/Acetaminophen can be liver toxic – while 2 x 500 mg four times a day is safe, if you take all 20 at once there is a good chance you get liver failure.

So as a rule of thumb many medications are liver toxic at high doses – in effect the liver can not process them fast enough and toxic products build up. A number of promising drugs across many areas have failed in Phase 2/3 trials when patient have got liver failure from them.

YMMV
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