Hello Vikramb,

Your doctor has made a good prescription – the SOVIHEP-V is Sofosbuvir/Velpatasvir which is known as Epclusa. It is a very good choice for treating genotype 3.

Your mothers low platelets and high prothrombin time suggest reasonably advanced liver disease, but we would expect the treatment to be successful and her quality of life to improve.

Using ribavirin is a good idea but can have some side effects – we need to keep an eye on FBC in particular to make sure no severe anemia or low platelets happen – if so we need to reduce/stop ribavirin.

The Ribavirin dose is usually 1000mg/day for patients <75kg and 1200mg/day for patients >75kg. This is taken 1/2 in morning and half at night so either

3x200mg morning + 2x200mg night (1000mg total)
3x200mg morning + 3x200mg night (1200mg total)

The low energy and swelling of legs probably relate to the liver problems.