Home › Forums › Main Forum › FixHepC Admin › Q & A › Soy an inducer of CYP3A4 ?

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  • 5 January 2016 at 6:14 am #8010
    Avatar photoPhoenix
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    @phoenix

    Have a look at this:

    https://www.researchgate.net/publication/259113039_Potential_modulation_on_P-glycoprotein_and_CYP3A_by_soymilk_and_miso_In_vivo_and_ex-vivo_studies

    5 January 2016 at 10:18 am #8016
    Avatar photozhuk
    • Guardian Angel
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    @zhuk

    Hear you on that, Pheonix. And I just found out the supposedly 100% whey protein I’ve been taking, wasn’t :pinch: (soy lecithin, in very small type lol) Only found one brand today which promised NO soy, well fingers crossed.

    Few other herbal/supplements too

    http://fixhepc.com/forum/drug-interactions/329-herbs-and-liver-safety.html#3028

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 11:03 am #8020
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    @flyingfox66

    I eat a lot of Miso…soy is very different when its fermented.
    Normal soy I avoid anyway…it’s mostly pretty toxic….but Miso…
    Do I need to forgo it on Dac? And Led as well?
    I might choose Led if I can still eat Miso.

    F49HepC25ysGT1a
    mild”

    5 January 2016 at 11:22 am #8021
    Avatar photoPhoenix
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    Hi FlyingFox, I don’t think we can draw definite conclusions yet. I have miso in the fridge too, and I decided not to have it for lunch today. But the link I posted was to a solitary study on rats, and I’ve only seen the summary page. I’ve seen soy described as an inhibitor elsewhere, which wouldn’t be so bad (if you want to dose up).

    I think we need to hear more from the medical and scientific people on the forum…

    5 January 2016 at 11:31 am #8022
    Avatar photozhuk
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    @zhuk

    Seems not, fox (speaking tentatively)

    Both sofosbuvir and ledipasvir are not metabolized by the cytochrome P450 system of enzymes but rather are substrates for p-glycoprotein.

    https://www.ncbi.nlm.nih.gov/pubmed/25553890

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 12:01 pm #8025
    Avatar photoPhoenix
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    @phoenix

    Zhuk the concerns about CYP3A4 relate to Daclatasvir.

    5 January 2016 at 12:02 pm #8026
    Avatar photoPhoenix
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    @phoenix

    Sorry Zhuk didn’t notice Flyingfox was talking about Led.

    5 January 2016 at 12:49 pm #8029
    Avatar photoflyingfox66
    • Guardian Angel
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    @flyingfox66

    I haven’t started treatment yet so I’m still trying to choose.
    Daclatasvir seems to be contraindicated for a few of my favourite things.

    F49HepC25ysGT1a
    mild”

    5 January 2016 at 12:56 pm #8030
    Avatar photoPhoenix
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    @phoenix

    personally I’m happy to give up lots of favourite things for 12 weeks. But I don’t want to convince you either way. Best talk to experts.

    5 January 2016 at 6:45 pm #8054
    Avatar photoLife
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    @life

    Hey Flying Fox!!!!

    I’ve been eating miso during 8 months before TX….Fantastic…! I stopped eating Macrobiotics on TX because it wasn’t possible anymore…Every tissue in your body will change…so…to me eating healthy was a difficult thing to do because all this years I ate so strict!!…..BUT Miso is full of omega and you should not eat that with TX….I don’t know…Miso is such an intestins-cleaner….I don’t do it…You will not be able to control your appetite anyways :P :P ….Good luck!

    flyingfox66 wrote:

    I eat a lot of Miso…soy is very different when its fermented.
    Normal soy I avoid anyway…it’s mostly pretty toxic….but Miso…
    Do I need to forgo it on Dac? And Led as well?
    I might choose Led if I can still eat Miso.

    5 January 2016 at 6:50 pm #8056
    Avatar photoLife
    • Guardian Angel
    • ★★★★★
    @life

    Hey! he TX will take control of your appetite anyways…Once you start TX, a lot of powerful things will be happening on a physical, emotional, spiritual level….With all this happening your body will need more calories and stuff…I’ve been very disciplined all these years…And on TX: uncontrolable LOL :)

    Phoenix wrote:

    personally I’m happy to give up lots of favourite things for 12 weeks. But I don’t want to convince you either way. Best talk to experts.

    5 January 2016 at 11:18 pm #8076
    Avatar photoflyingfox66
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    @flyingfox66

    Interesting…omegas are not good on Tx?
    Thats really why I am concerned about Miso…its my probiotic (I use unpasteurised).
    Maybe once my digestion comes back on line I won’t need it so much.
    I’m not hugely strict diet wise, though I always prefer fresh food.
    Rich food has made me feel sick for years and years now. Be funny if that changes. I might get fat! :D

    F49HepC25ysGT1a
    mild”

    5 January 2016 at 11:28 pm #8077
    avatar876.jpegGaj
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    @gaj

    I’m battling that myself ff66,

    All the foods I couldn’t eat previously look, smell and taste delicious now. I use to have to make myself eat at mealtimes to keep condition. Now, I find I want to eat all day!

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    5 January 2016 at 11:31 pm #8078
    Avatar photoflyingfox66
    • Guardian Angel
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    @flyingfox66

    Ah well hopefully we’ll have so much energy we’ll be able to run around to burn it all off :)

    F49HepC25ysGT1a
    mild”

    5 January 2016 at 11:52 pm #8080
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Well yes, but all that exercise just makes me even hungrier. I am feeling fitter though. :woohoo:

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

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