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  • 10 January 2016 at 6:41 am #8510
    A.L.
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    • Recovery Champion
    • ★★★★
    @a-l

    Very interesting! This is the kind of informative post we don’t often see (anywhere).

    Can I ask, please, what is the difference between the 2 traces for each sample. Some of them are not perfect pairs, so I assume there is a difference of some kind.

    A.L.

    G4, F4, cirrhosis.

    Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.

    YEAR….. ALT….. AST….. GGT… FERRITIN………………………………….
    2009……. 210….. 215….. 953….. 1400……….. (Bad health, stupidity)
    2015……. 60……. 45……. 150….. 360…………. (Improved diet and health, FixHepC treatment)
    2016……. 20……. 24……. 25……. 156…………. (SVR 12)

    10 January 2016 at 8:06 am #8514
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Can I ask, please, what is the difference between the 2 traces for each sample. Some of them are not perfect pairs, so I assume there is a difference of some kind.

    Yes, good pickup.

    I chose this image because it had a nice lot of comparator samples all on the one page and they are HCV RNA runs.

    These images are Southern Blot HCV RNA comparing before and after seroconversion HCV RNA results.

    Here’s the source article which is interesting in and of itself in that it looks at the process of becoming HCV Antibody positive as it compares to serum HCV RNA levels.

    http://www.bloodjournal.org/content/94/4/1183?sso-checked=true

    YMMV

    13 January 2016 at 6:55 am #8895
    A.L.
    • Topics: 3
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    • Total: 64
    • Recovery Champion
    • ★★★★
    @a-l

    Thanks for that. Interesting attached article (analysing 358 drug users in an HIV study that began in 1985 and then finding 19 of them who became infected with HCV. Just trying to imagine the logistics involved with paperwork and specimen collection and storage with that amount of people, especially considering that the paper itself was published in 1999.)

    G4, F4, cirrhosis.

    Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.

    YEAR….. ALT….. AST….. GGT… FERRITIN………………………………….
    2009……. 210….. 215….. 953….. 1400……….. (Bad health, stupidity)
    2015……. 60……. 45……. 150….. 360…………. (Improved diet and health, FixHepC treatment)
    2016……. 20……. 24……. 25……. 156…………. (SVR 12)

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