Home › Forums › Main Forum › FixHepC Admin › Q & A › Should I add Ribavirin to my Tx?

Viewing 2 posts - 1 through 2 (of 2 total)
  • Author
    Posts
  • 18 January 2016 at 6:27 am #9593
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Hi Tim,

    The good news is that you are UND. :)

    Looking at your other bloods I suspect you need expert medical advice regarding adding Ribavirin to your Tx rather than from layman forum members. Are you being monitored by a liver specialist?

    edit: Talking mostly your haemos, etc. re anaemia

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    18 January 2016 at 3:22 pm #9663
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Tim,

    Those numbers look fine. Here is all the trial data for Sof+Led

    NAIVE
    default: svr: 97%, trials: ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317)
    gt1a: default: svr: 97%, trials: ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317)
    gt1b: default: svr: 99%, trials: ION-1 100% (67/67) ION-3 98% (43/44) Aggregate 99.1% (110/111)
    F4
    default: svr: 97%, trials: ION-1 97% (32/33)
    w12: svr: 97%, trials: ION-1 97% (32/33)
    w12riba: svr: 100%, trials: ION-1 100% (33/33)
    w24: svr: 97%, trials: ION-1 97% (31/32)
    w24riba: svr: 100%, trials: ION-1 100% (36/36)
    FAIL
    default: svr: 94%, trials: ION-3 94% (102/109)
    w12: svr: 94%, trials: ION-3 94% (102/109)
    w12riba: svr: 96%, trials: ION-3 96% (107/111)
    w24: svr: 99%, trials: ION-3 99% (108/109)
    w24riba: svr: 99%, trials: ION-3 99% (110/111)

    While the 100% cure rate looks impressive with F4 + Riba the 97% represents 1 person. If you look at the numbers there is scant evidence of Riba making any difference. We know that for F3/F4 GT3 patients Riba does not improve SVR rates with 24 weeks treatment, in fact in every +Riba group the results were worse.

    YMMV

  • Author
    Posts
Viewing 2 posts - 1 through 2 (of 2 total)
  • You must be logged in to reply to this topic.