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8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24395
For patients who are all of
The guidelines suggest 8 weeks treatment is ok. But is it really? In this VA study of 4,365 patients they concluded: Conclusions: In this real-world cohort, SVR rateswith LDV/SOF6RBV nearly matched the rates reported in clinical trials and were consistently high across all sub-groups; those without cirrhosis but with HCV RNA<6,000,000 IU/mL were less likely to achieve SVR with 8 weeks compared to 12 weeks of therapy, although the numeric difference in SVR rates was small. www.researchgate.net/publication/3016714..._C_Infected_Patients Hmm, small. What's small? Small is 96.6% SVR at 12 weeks compared to 93.2% at 8 weeks. Putting that in failure terms: 3.4% failure at 12 weeks compared to 6.8% failure at 8 weeks. So if you fit the criteria, and only do 8 weeks you have DOUBLE the failure rate. DOUBLE is not small to me. Double is big. I don't know about you, but I would be wanting that extra 3.4% Also note this. The same study shows (as did we with generics) that patients who are detectable at the 4 week test (that's detectable at all and includes <15 detected) are 2.5 times more likely to fail, compared to patients who are undetected at this point. So the only reason that I personally would do only 8 weeks would be if that was all I could get. If I was still detected at the 4 week mark I would be very nervous. If you are female, if you have low fibrosis, if you are undetected at 4 weeks these are all good, but still - DOUBLE THE FAILURE RATE Double is not small. YMMV | |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24396
Unlike fertilizer, more is better. No place to cut corners here. Go the 12 week route. m This email address is being protected from spambots. You need JavaScript enabled to view it. forums.delphiforums.com/generichcvtx G 1a F-1 Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil 11/17/15 4 wk lab ALT 17 AST 16 <15 11/18/15 Started Harvoni 12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND 1/14/16 Fin. Tx 7/07/16 UND SVR 24 | |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24508
In my case <15 was undetected. The doctor told me that <15 detected was not what I wanted, but since mine was undetected he had it that I would most likely not relapse. So again "undecided <15" is good if your laboratory can only go down to <15. But if you have "<15 decteded", yes this is reason to start thinking retreat. Dr Freeman if this is so why don't they develop better testing to go all the way to zero undetected? The labs here in the US mostly are <15, undetected or detected, why? Contracted HCV 1980's Geno Type 1a F3 ( doc says once treated I'll be F2 maybe F1) Meds shipped 6/17/2016 arrived early 7/2016 Viral count - 3,471,080 4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected) 8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected) 11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected December 19th 2016: Cured! Viral count: zero!!! 2018 viral count: still zero! Cured! The following user(s) said Thank You: mgalbrai, Greedfighter | |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24512
. HCV RNA consists of 9600 bases. Each weighs about 650 Daltons and 1 Dalton is 1.67 x 10-24grams so you could multiply all those together and get a really small number - about 10-17 grams. That's really really really really really really really really really really really really really really really really really small. 0.00000000000000001 g We use the process PCR - which is Polymerase Chain Reaction like this. We add some blood that may have RNA in it to a chemical soup of RNA duplicators. We incubate it to make lots of RNA, and only now do we have enough to count. So that is problem 1. Problem 2 is that it only takes about 10 Hep C virions (viuses) to cause infection. If these were all in your blood, and there were only 10, and you have 5 litres of blood (you do) then we would need to draw off 500 ml to have a chance of getting 1 virus. We only take 5 ml. And of course most of the HCV is NOT in your blood - it is in liver and other cells. So while it would be great to measure down to zero it is fundamentally impossible to do so because:
YMMV | |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24520
Take 12 weeks! m This email address is being protected from spambots. You need JavaScript enabled to view it. forums.delphiforums.com/generichcvtx G 1a F-1 Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil 11/17/15 4 wk lab ALT 17 AST 16 <15 11/18/15 Started Harvoni 12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND 1/14/16 Fin. Tx 7/07/16 UND SVR 24 | |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24525
What he said! YMMV The following user(s) said Thank You: Greedfighter | |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24533
| in my case I chose 12 weeks ( had to..... ), however I would not put my bet on the 8 weeks. In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”. HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic. By sharing this Youtube video you might save someone’s life! My TX: HEPCVIR-L[generic Harvoni]-India SVR52 achieved |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24535
| Go for 12 weeks, it's such a small price to pay for a big advantage Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 |
8 weeks versus 12 weeks Harvoni 6 years 11 months ago #24591
My doc said "your good to go for 8 weeks". Then he said "if you can get 12 weeks do it" I did 12 and did not look back, glad I did. Even if VL is low, under 6,000,000, go 12 weeks to be sure. And what Mike G and Dr F said! Contracted HCV 1980's Geno Type 1a F3 ( doc says once treated I'll be F2 maybe F1) Meds shipped 6/17/2016 arrived early 7/2016 Viral count - 3,471,080 4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected) 8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected) 11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected December 19th 2016: Cured! Viral count: zero!!! 2018 viral count: still zero! Cured! The following user(s) said Thank You: DrJames | |
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