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Reduction of liver fibrosis without antiviral treatment
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected



17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72


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Serg wrote:
"I can be positive with TTW or hepatitis G viruses by PCR test, for example. But this does not mean that i have a "disease", because such viruses will not cause symptoms for me (like cirrhosis). Analogically, if HCV will not cause symptoms for me - what is the reason to define such situation as a "disease"? Of course, for such proportion of patients, who will develop cirrhosis/extrahepatic manifestations during lifetime - HCV is a disease. But many infected people will not develop symptoms."
The circular logic of this argument is counterproductive.
Serg, If you don't believe you have a disease, may I ask what benefit or purpose there is to your participation here?
Your argument seems to be that the only rationale for treatment, or credible indicator of 'disease' would be if one is actually dying of cirrhosis - which is exactly the operative assumption of Big Phama and Big Insurance for denying treatment to Hep C patients until one is by their definition "sick enough".
Frankly, if I were Big Pharma/Big Insurance, your argument would be precisely the one I would be making.
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
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en.m.wikipedia.org/wiki/GB_virus_C
It appears that HGV is a benign blood borne virus, at any one time our bodies are host to zillions of such viral/bacterial/fungal life forms. The fact that it has (had) a name similar to several diseases does not make it one.
Serg
I have amended your statement/question above to reflect the reality that while chronic HCV is a slow acting disease that doesn't always cause obvious damage, it is still having some sort of impact on the body. LFTs within nominal range that drop on treatment is evidence of that.
Errr....Google says that TTW is a computer game that can get infected with the SHuer3 virus??? (Take one subscription to Norton annually.

G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND



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No, i dont think this way. If treatment is "prophylaxis" of cirrhosis/extrahepatic manifestations - people should have full rights to prevent cirrhosis/extrahepatic manifestations - whether they are sick or not.
Rather, semantics of "hcv is a disease in every infected", "everyone must undergo treatment", and "achieve a cure" may be promoted by Big Pharma for maximizing their profit. If we can convince infected people that they are all "sick" - it is much simple to sell him medication with huge prices, than sell prophylactic drugs to healthy people.
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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Gaj wrote:


Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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Gaj wrote:
Symptoms are the things that affect the quality and quantity of life; it is the development of symptoms that concerns patients. Symptoms of liver failure include internal bleeding from dilated veins (called varices), excessive fluid accumulation in the legs (called edema) and abdomen (called ascites), and slowing down of thinking with confusion and even coma (called hepatic encephalopathy). Another symptomatic complication of cirrhosis is the development of hepatocellular carcinoma.
The point is that if only the enzyme tests remain abnormal, and symptoms of liver failure never occur, there is no clinical “dis-ease”. Treatment is irrelevant because it is impossible to make an asymptomatic patient feel better and, at the time of treatment, patients do not have symptoms of end-stage liver disease.
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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Serg wrote:
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
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- Posts: 501
- Thank you received: 1816
Thanks to all involved for moving on with the discussion.
Content redacted.
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
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- rohcvfighter
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- Vindecat de HCV cu med. generice. Cured with generics HCV drugs.
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Getting treated for HCV is a vey individual decision / choice, no matter if it is with DAAs, IF+RIB or any other mixture of substances one may identify as possible cure.
So, it is up to everyone to decide in what extent they want to research it and make the own opinion.
Me personally I am curious to know how the fibrosis may be reduced without treatment .
In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic.
By sharing this Youtube video you might save someone’s life!
My TX: HEPCVIR-L[generic Harvoni]-India
SVR52 achieved
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Gaj wrote:
HCV RNA Persists in Liver Explants of Most Patients Awaiting Liver Transplantation Treated With an Interferon-Free Regimen.
www.ncbi.nlm.nih.gov/m/pubmed/27373513/#
P.
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Serg, I also think that you need to take into consideration whether you treated and failed treatment previously because studies have shown that may impact their health in the future.
P.
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fitz, I did not wrote that "Big Pharma dispenses treatment to everyone", please do not ascribe to me such thoughts. I will skip some your "ad hominem" arguments, but i agree that these discussed things about "semantics" may seems like some "offtopic" there... And, anyway, we cannot change current "semantic" in this area.
Best wishes,
Serg
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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Price wrote:
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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Thanks Price, very new article.
Although not able to access the full article yet, I see that 85% of them went on to acheive SVR after they had their liver transplant so presumably they became undetected? I wonder if having a compromised immune system prior to transplant was preventing them from clearing the stragglers that the DAAs hadn't affected?
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND



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Full article is available via sci-hub: dx.doi.org.sci-hub.cc/10.1053/j.gastro.2016.06.025
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
Please Log in or Create an account to join the conversation.
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