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emo Reduction of liver fibrosis without antiviral treatment

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6 years 3 weeks ago #19713



:silly: :silly: :silly:
;)

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1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected :cheer: :) , FBG 11.9 :huh:
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
:) (Accu-Chek Mobile & Omron Auto BP Monitor) :)
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6 years 3 weeks ago #19714

Serg wrote:

"I can be positive with TTW or hepatitis G viruses by PCR test, for example. But this does not mean that i have a "disease", because such viruses will not cause symptoms for me (like cirrhosis). Analogically, if HCV will not cause symptoms for me - what is the reason to define such situation as a "disease"? Of course, for such proportion of patients, who will develop cirrhosis/extrahepatic manifestations during lifetime - HCV is a disease. But many infected people will not develop symptoms."


The circular logic of this argument is counterproductive.

Serg, If you don't believe you have a disease, may I ask what benefit or purpose there is to your participation here?

Your argument seems to be that the only rationale for treatment, or credible indicator of 'disease' would be if one is actually dying of cirrhosis - which is exactly the operative assumption of Big Phama and Big Insurance for denying treatment to Hep C patients until one is by their definition "sick enough".

Frankly, if I were Big Pharma/Big Insurance, your argument would be precisely the one I would be making.

Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
Last Edit: 6 years 3 weeks ago by fitz.
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6 years 3 weeks ago #19715

virus C (GBV-C), formerly known as hepatitis G virus (HGV) and also known as HPgV is a virus in the Flaviviridae family and a member of the Pegivirus genus,[1] is known to infect humans, but is not known to cause human disease

en.m.wikipedia.org/wiki/GB_virus_C

It appears that HGV is a benign blood borne virus, at any one time our bodies are host to zillions of such viral/bacterial/fungal life forms. The fact that it has (had) a name similar to several diseases does not make it one.

Serg
"Analogically, if HCV will may not cause noticeable symptoms for me - what is the reason to define such situation as a "disease"?"

I have amended your statement/question above to reflect the reality that while chronic HCV is a slow acting disease that doesn't always cause obvious damage, it is still having some sort of impact on the body. LFTs within nominal range that drop on treatment is evidence of that.

Errr....Google says that TTW is a computer game that can get infected with the SHuer3 virus??? (Take one subscription to Norton annually. ;) )

G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 6 years 3 weeks ago by Gaj.
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6 years 3 weeks ago #19716

Serg, If you don't believe you have a disease, may I ask what benefit or purpose there is to your participation here?
fitz, I have F4 (cirrhosis) - hence, i definitely have a disease.

Your argument seems to be that the only rationale for treatment, or credible indicator of 'disease' would be if one is actually dying of cirrhosis - which is exactly the operative assumption of Big Phama and Big Insurance for denying treatment to Hep C patients until one is by their definition "sick enough".

No, i dont think this way. If treatment is "prophylaxis" of cirrhosis/extrahepatic manifestations - people should have full rights to prevent cirrhosis/extrahepatic manifestations - whether they are sick or not.

Rather, semantics of "hcv is a disease in every infected", "everyone must undergo treatment", and "achieve a cure" may be promoted by Big Pharma for maximizing their profit. If we can convince infected people that they are all "sick" - it is much simple to sell him medication with huge prices, than sell prophylactic drugs to healthy people.

Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91

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6 years 3 weeks ago #19717

Gaj wrote:

Errr....Google says that TTW is a computer game that can get infected with the SHuer3 virus??? (Take one subscription to Norton annually. ;) )
Oh, i am sorry for error - of course, TTV virus, not TTW. :)

Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91

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6 years 3 weeks ago #19718

Gaj wrote:

LFTs within nominal range that drop on treatment is evidence of that.
If i correctly understand, LFTs and PCR are signs, not symptoms. A quote about such things (really, i dont agree with all statements of this relatively old article):
let us consider the difference between signs and symptoms. Signs are typically abnormal blood tests; these are the tests that doctors order to monitor patients. Some signs measure the degree of inflammation (such as enzymes called aminotransferases, known by patients as “ALT” or “AST”). While the ALT or AST test is often called a “liver function test”, it really does not measure any function that the liver performs, but simply assesses the presence of liver cell damage. It is more appropriately denoted as a “liver enzyme test”. The other test (sign) that we need to consider is the one that measures the number of hepatitis C particles that are present in the blood (known as “viral load” or “viral titer”). Traditionally, the success of treatment has been measured by the absence of detectable viral particles in the blood at least six months after the therapy has been stopped. This prolonged clearance of virus from the blood stream is known as a “sustained viral response” or SVR.
Symptoms are the things that affect the quality and quantity of life; it is the development of symptoms that concerns patients. Symptoms of liver failure include internal bleeding from dilated veins (called varices), excessive fluid accumulation in the legs (called edema) and abdomen (called ascites), and slowing down of thinking with confusion and even coma (called hepatic encephalopathy). Another symptomatic complication of cirrhosis is the development of hepatocellular carcinoma.
The point is that if only the enzyme tests remain abnormal, and symptoms of liver failure never occur, there is no clinical “dis-ease”. Treatment is irrelevant because it is impossible to make an asymptomatic patient feel better and, at the time of treatment, patients do not have symptoms of end-stage liver disease.
( www.news-medical.net/health/Hepatitis-C-...d-possible-harm.aspx )

Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91

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6 years 3 weeks ago #19719

Serg wrote:

Serg, If you don't believe you have a disease, may I ask what benefit or purpose there is to your participation here?
fitz, I have F4 (cirrhosis) - hence, i definitely have a disease.

Rather, semantics of "hcv is a disease in every infected", "everyone must undergo treatment", and "achieve a cure" may be promoted by Big Pharma for maximizing their profit. If we can convince infected people that they are all "sick" - it is much simple to sell him medication with huge prices, than sell prophylactic drugs to healthy people.

Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
Last Edit: 6 years 3 weeks ago by fitz.

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6 years 3 weeks ago #19720

Thanks to all involved for moving on with the discussion.

Content redacted.

Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!
Last Edit: 6 years 3 weeks ago by fitz.

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6 years 3 weeks ago #19721

Getting treated for HCV is a vey individual decision / choice, no matter if it is with DAAs, IF+RIB or any other mixture of substances one may identify as possible cure.

So, it is up to everyone to decide in what extent they want to research it and make the own opinion.

Me personally I am curious to know how the fibrosis may be reduced without treatment :).

In fiecare an HCV ucide peste 500000 oameni.Medicamentele generice pentru hepatita C functioneaza. Nu deveni statistica! Cauta pe Google “medicamente generice pentru hepatita C”.
HCV kills more than 500000 people every year. HCV generic drugs work. Don't become a statistic.
By sharing this Youtube video you might save someone’s life!
My TX: HEPCVIR-L[generic Harvoni]-India
SVR52 achieved
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6 years 3 weeks ago #19722

Gaj wrote:

Both the studies you list in the above quote are from 2004 and well prior to the development of modern DAAs such as Sofosbuvir, Ledipasvir, Daclatasvir, etc, etc. If you are going to cite studies to try to support your claims about the modern DAAs you need to provide more current information.
Here's a current one....

HCV RNA Persists in Liver Explants of Most Patients Awaiting Liver Transplantation Treated With an Interferon-Free Regimen.

www.ncbi.nlm.nih.gov/m/pubmed/27373513/#

P.

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6 years 3 weeks ago #19723

Serg, I also think that you need to take into consideration whether you treated and failed treatment previously because studies have shown that may impact their health in the future.

P.

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6 years 3 weeks ago #19724

fitz, I did not wrote that "Big Pharma dispenses treatment to everyone", please do not ascribe to me such thoughts. I will skip some your "ad hominem" arguments, but i agree that these discussed things about "semantics" may seems like some "offtopic" there... And, anyway, we cannot change current "semantic" in this area.

Best wishes,
Serg

Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91

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6 years 3 weeks ago #19725

Price wrote:

Serg, I also think that you need to take into consideration whether you treated and failed treatment previously because studies have shown that may impact their health in the future.
Yes, of course.

Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91

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6 years 3 weeks ago #19726

Thanks Price, very new article. :)

Although not able to access the full article yet, I see that 85% of them went on to acheive SVR after they had their liver transplant so presumably they became undetected? I wonder if having a compromised immune system prior to transplant was preventing them from clearing the stragglers that the DAAs hadn't affected?

G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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6 years 3 weeks ago #19727

Full article is available via sci-hub: dx.doi.org.sci-hub.cc/10.1053/j.gastro.2016.06.025

Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
The following user(s) said Thank You: Gaj

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