TOPIC:

Actually I thought it was placebo at first, but 12 days later it is still there including all the benefits I listed above. Keep moving forward!

I am concerned about the total effectiveness with generics, as the relapse news is now seemingly hitting full stride with people testing SVR 1-16-24.
So is it that the voices we hear are those whom have failed SVR and the ones that are 100% done never post any further?
Please let me know how one calculates the generic Harvoni with branded Harvoni successes and failures.
Thank you all.

PS:: I am doing very well, I should have my 14 labs back today.

Hi Sven,

to me (as I mentioned in another thread) some worries are gone and some new came in and I try to not lose my optimism.

Couple of tips that might help you:
- dr. Freeman announced in April 2016 a success rate (SVR12) of ~95% in a group of 448 people. So you have quite a good argument to think positive ;
- relapse is sad and is part of this HCV reality. Even though I do not wish to hear about relapse, I am very thankful to those who decided to post such news. It mobilizes me to stay alert and ... prepares me to continue the fight if necesary.
- I would have questioned the transparence of fixhepc.com in case there would have been no news about relapse. And now as long as the there exist this transparency about relapse, it does help me to keep my sense of reality.
- there are several statements on this forum of people who reached SVR12 and who mentioned that waiting to reach the "confirmation time" for SVR12 was not so easy, having fears/anxiety, etc. So it happened to others too and it helps to know this and to talk about it.

Last but not least, I think it would have been kind of boring to just get rid of the "HCV buddy" after having had it so many years .... So a little bit of worries might be indicated, just like alcohol (have a look on a thread on the forum about alcohol).

You are now in the middle of the game and you have only one thing to do: CONTINUE , do not let the fears or worries turn you down.
Thinking positive helps also your liver fight better

Cheers,
RHF

Thanks man, appreciate it and I agree 100%.

I am concerned about the total effectiveness with generics, as the relapse news is now seemingly hitting full stride with people testing SVR 1-16-24.

Hi Sven, the SVR12 rates overall are > 90% which is as good as could be hoped for.

Amongst the dozens of reasons NOT to be involved (and there are lots) one of the major ones was the 100% certain knowledge that an SVR rate of 95% is also a 5% failure rate which means that I knew at least 5 out of every 100 patients would fail to SVR, even if we got real world results as good as the clinical trials, which once again, we (as in doctors) know is never the case. I resolved that if we were not seeing 90% I would reassess things. We are, which is one reason we continue.

There are literally thousands of patients taking generics so there are hundreds of people expected to fail to SVR - any one of whom might choose to sue me or others involved in their treatment. REDEMPTION is as much about CYA as it is about proving generic copies are effective, because it is only in the context of a group that an individual relapse has any context. So if a lawyer comes along an says we are starting a class action because patient's A B and C have relapsed I'll go good for you, but guess what, patients D E F G H I J K L M N O P Q R S T U V W X Y and Z did not, and I have the evidence, so perhaps you'd like to re-consider your case because you're going to lose so kindly FOAD .

So is it that the voices we hear are those whom have failed SVR and the ones that are 100% done never post any further?

Yes, if you look at the forum and do a search like this (from the search tab)

fixhepc.com/forum/search.html?query=trea...c&childforums=1&ids=

Which is for posts more than 6 months ago, searched for the word "treatment", sorted by earliest first you will see hundreds of names of people you've probably never heard of. They came, they treated, and they've moved on. Treatment gives people back their lives and while I miss their company, humour and insights, it's the way it should be.

A big reason this forum exists is also CYA in the context of informed consent. Anyone who wanted to say I had no idea that there are side effects, that patient's relapse, etc, etc would be hard pressed to prove that was because they were not informed. This forum is far more transparent then any drug company trial and carries far more real world information about DAA treatment than pretty much anywhere else in the world, and unlike Big Pharma trials where the results are presented with a "trust us this is what we got", this forum makes our results pretty transparent - if generic DAAs were not delivering results you would be reading a whole lot more relapse and a whole lot less SVR.

If you've got a strong stomach read this fixhepc.com/blog/item/26-pharma-scores-rap-drug-cover-ups.html which is an article from the Australian called "Pharma Scores Rap Drug Cover Ups" reporting on this article from the BMJ bmjopen.bmj.com/content/5/11/e009758.full.pdf where it is noted that with Gilead's new HIV drug Stribild they did 34 trials BUT only reported 21% of them (ie 7). You do have to wonder what the other 27 unpublished trials turned up, but it would be naive to think they contain better results.

Please let me know how one calculates the generic Harvoni with branded Harvoni successes and failures.

You do it by taking a group of CONSECUTIVE patients - 448 - in our case - and keep a log of what happens counting all the successes and all of the failures.

Interestingly we are also keeping a log of originator medication patients in Australia and, as expected seeing both success and relapse.

I have patients who have replapsed post anything and everything you could name - Harvoni, Sovaldi, Ribavirin, PEG, Olysio, Daklinza, Zepatier, V-pak - we have good, we don't have perfect.

Treatment is a gamble. There are risks, there are benefits, there are failures and successes. There will always be better drugs just around the corner. For some people waiting may be a good option. Others will die waiting..... 500,000 last year to be more precise.

But do generics deliver similar results to the branded medications, yes, just like the HIV generics taken by about 15 million people around the world. These medications are largely made by the same companies in both originator and generic forms.

First and foremost, thank you. Secondly I find you incredible to say the least. I am not any person whom gives credit or kudos to anyone I meet no matter the circumstance, but you sir are an anomaly. The world is full of people that say "I could have done this and I should have done that or I'm going to to do this". It is short on people whom actually perform and change the way the world or society thinks, I must say again sir you are an individual whom sees the world as it could be and not how it is. I sincerely applaud your candor, intelligence, persistence, desire and those traits alone are omnipotent. Your intelligence is only secondary to these traits you have.
I personally would follow you to the end of the Earth if you told me I would find my success and happines there.
So yes I do believe everything I said and I am sure I have many who would join my journey when you are the leader.
May God bless you always.

Hi Sven,

I was happy to feel good for 24 weeks and grateful for that. The relapse is not good news, but the 24 weeks were.

Definition of 'feel good': Not feel like a lethargic blob that mainly got out of bed in the morning to have breakfast with the intention of returning to bed ASAP.


Jeff

Hi everybody . I received my 14 day bloods today.
Yes it has not been this low in decades! Yes I am very upbeat about these tests today.
Thank you all again, I appreciate everyone here!,

I'll try this again.
Ugh it upload everything name rank and serial number.

The great news is:
1) 22 AST(SGOT)
2) 22 ALT(SGPT)

Everything else is great except my glucos is 118.

Yes I am happy!

Thank you all for being here, it is going great.

My other edits were due to the photograph only in a few texts .
Sorry about that but it's been a good day !

Those LFT scores are looking sweeeeet Sven

Those LFT scores are looking sweeeeet Sven

Thank you!! I just posted the correct photo!

Outstanding results, Sven! Two weeks!!! Just WOW!

Your generic DAAs are kicking the snot out of HCV, and LFTs are well within the normal Range.

Glucose is a little high (a touch out of the normal range), but I'm sure someone will be along shortly with some tips on getting that down.

Great job, brother!

Love the video, couldn't have been a better example !

You know man I am so enthusiastic about this treatment its hard to contain, of course I do my best.
Yes the glucose is a bit high, it is the snacks I tend to eat. I'll be knocking those off.
Anyway thanks brother for the good words, I know your kicking butt too!
In good health to you my friend.

Sven wrote: I am concerned about the total effectiveness with generics, as the relapse news is now seemingly hitting full stride with people testing SVR 1-16-24.
So is it that the voices we hear are those whom have failed SVR and the ones that are 100% done never post any further?
Please let me know how one calculates the generic Harvoni with branded Harvoni successes and failures.
Thank you all.

Hi Sven,

I'm curious to understand how you come to the conclusion that the reason people are relapsing is that they are using generics.

A few points and questions for you -
people who don't relapse probably won't post here after they have received SVR.
do you know for sure that everyone who has relapsed has taken generics?
do you know the relapse stats for people on branded medications?

Just asking