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Sof+Led vs Sof+Dac - and the winner is..... 8 years 3 months ago #8062
Here are the available studies as they relate to GT1 and Sof+Led (Harvoni) vs Sof+Dac (Sovaldi + Dalinza) Sof+Dac GT1 ALLY-2 naive (80/83) experienced (43/44) Aggregate 96.8% (123/127) GT1a ALLY-2 naive 96% (68/71) experienced 97% (32/33) Aggregate 96.2% (100/104) GT1b ALLY-2 ALLY-2 naive 100% (12/12) experienced 100% (11/11) Aggregate 100% (23/23) F4 ALLY-2 naive 89% (8/9) experienced 92% (12/13) Aggregate 90.9% (20/22) Past Failure ALLY-2 98% (43/44) Sof+Led GT1 ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317) GT1a ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317) GT1b ION-1 100% (67/67) ION-3 98% (43/44) Aggregate 99.1% (110/111) F4 ION-1 97% (32/33) Past Failure ON-3 94% (102/109) Not a lot between them, but the data for Sof+Led is more robust due to better n I would be happy taking either. Sof+Dac is a better choice if taking antacid type medications because Ledipasvir needs acid for absorption. YMMV The following user(s) said Thank You: LondonGirl, poodle, mgalbrai, Lisa-KT-facebook, Ariel, Tina-Hill-facebook, zhuk, isaing4, darbara, honker, frankiej, Meg | |
Sof+Led vs Sof+Dac - and the winner is..... 8 years 3 months ago #8086
What acid does Ledipasvir need ? Treatment naive F 3/4 Genotype 1 a & b V/L 17 MILLION Started Harvoni 11th Dec 2015 for 12 weeks 4 weeks VL UND 6 WEEKS ALT 32, AST 34 EOT 03/03 2016 ! UND ALT 34, AST 26 04.04.2016 SVR 4 26.05.2016 SVR 12 16.08.2016 SVR 24 | |
Sof+Led vs Sof+Dac - and the winner is..... 8 years 3 months ago #8101
Stomach acid in which some have too much hence the use of antacids etc. Diagnosed Hep C 2013 Geno Type: 1a Treatment: Naïve Cirrhosis F4 2015 GGT 227 AST 79 ALT 89 Platelets 88 2016 Treatment Generic Harvoni Finished 29 March 2016 GGT 30 AST 19 ALP 67 Platelets 91 Qualitative Test Results April 12 Hepatitis C NAT (NA): Not Detected P.C.R Test for Hep C 4th July: Negative Virus Free This email address is being protected from spambots. You need JavaScript enabled to view it. | |
Sof+Led vs Sof+Dac - and the winner is..... 8 years 1 week ago #14617
If I understood correctly, Dac is just slightly better than Led in types 1 and 4. And we already knew that type 3 has to use Dac. So the evidence is in ... Daclatasvir is the pan-genotypic choice. And now AbbVie is getting high success rates WITHOUT Sofosbuvir !!! www.prnewswire.com/news-releases/abbvies...irals-300252074.html Let the price competition begin! | |
Sof+Led vs Sof+Dac - and the winner is..... 7 years 11 months ago #16378
Hi I am a bit confused about both what DAAs combination and length of tx are best for: Genotype 1b VL 1.200.000 Tx Naive F0 - F1 ALT and other enzymes levels on the higher end of normal. What is the criteria for either 8 weeks tx versus 12 weeks? Thank you. Blood transfusion in 1992 - Diagnosed in 2007 Tx naive -G1b - F1 VL 2.270.000 ALT 40 Start tx June 4th/2016 with DAAs - Sof/Led from India Bloods on two weeks of tx (June 18th) AST 17 - ALT 10 - GGT 19 Virus UND Bloods on six weeks of tx (July 16th) AST 17 - ALT 8 - GGT 12 Virus UND EOT on August 8th (did 9 weeks and 3 days) SVR 4 Virus UND (September 7th) AST 13 - ALT 5 SVR 14 Virus UND (November 12th) | |
Sof+Led vs Sof+Dac - and the winner is..... 7 years 11 months ago #16379
Hi Meg, With Harvoni and your profile - 1b, naive, low fibrosis, low viral load (<6 million) the evidence is that 8 weeks treatment is just as effective as 12. You could do 12 for insurance/reassurance, but you fit the shorter treatment profile and using it would save you $500 YMMV | |
Sof+Led vs Sof+Dac - and the winner is..... 7 years 11 months ago #16394
Thank you! Eight weeks tx feels like very good news! Blood transfusion in 1992 - Diagnosed in 2007 Tx naive -G1b - F1 VL 2.270.000 ALT 40 Start tx June 4th/2016 with DAAs - Sof/Led from India Bloods on two weeks of tx (June 18th) AST 17 - ALT 10 - GGT 19 Virus UND Bloods on six weeks of tx (July 16th) AST 17 - ALT 8 - GGT 12 Virus UND EOT on August 8th (did 9 weeks and 3 days) SVR 4 Virus UND (September 7th) AST 13 - ALT 5 SVR 14 Virus UND (November 12th) | |
Sof+Led vs Sof+Dac - and the winner is..... 6 years 11 months ago #24504
Treatment of GT1 in Denmark: Genotype 1 without cirrhosis Hi James Freemann For your information: (1st choice to min. 70% of Population) February 2017 Here is what the Danish health authorities recommend if they are offered treatment in Denmark Viekirax® (ombitasvir 12.5 mg + paritaprevir 75 mg + ritonavir 50 mg) 2 tablets 1 x Daily for 12 weeks + Exviera® (dasabuvir 250 mg) 2 x daily in 12 weeks + Ribavirin 2 x daily for 12 weeks Before, there were 6 different treatment proposals, all of which were equal: Genotype 1 without cirrhosis Use as 1st choice for mine. 70% off population (Genotype 1) Sep 2016: (Strong recommendation for) Sofosbuvir (400 mg) + ledipasvir (90 mg) 1 x daily For 8-12 weeks * or Sofosbuvir 1 x daily (400 mg) and simprevir 1 x daily (150 mg) for 12 weeks or Sofosbuvir 1 x daily (400 mg) and daclatasvir 1 x daily (60 mg) for 12 weeks or Ombitasvir (12.5 mg) + paritaprevir (75 mg) + ritonavir (50 mg) 2 tablets 1 x daily and dasabuvir (250 mg) 2 x daily for 12 weeks ** or Sofosbuvir (400 mg) + velpatasvir (100 mg) 1 x daily For 12 weeks or Elbasvir (50 mg) + grazoprevir (100 mg) 1 x daily for 12 week *** Greeting Gert Probably infected 30 years ago Genotype: 1a Fibroscan 4,8 - 18 january 2017 Virus in the blood 18 January 2017 10.400000 / Alat 102 Started treatment January 19, 2017 Feb.15 - Alat 76 - virus: UNDETECTED March 15 - Alat 34 - virus UNDETECTED April 12 - Alat 40 Asat 34 - virus UNDETECTED / Taking the last pill May 10 SVR4 - Alat 36 -virus UNDETECTED July 5 SVR12 - Fibroscan 3,8 Alat 39 - virus UNDETECTED Sep. 27 SVR24 - ALAT 24- virus UNDETECTED Marts 14 - 2018 SVR48 - ALAT 26- virus UNDETECTED | |
Sof+Led vs Sof+Dac - and the winner is..... 6 years 11 months ago #24505
Since writing this new evidence has come to light. fixhepc.com/forum/experts-corner/1576-8-...2-weeks-harvoni.html In short, 8 weeks is probably a bad choice unless you are very strapped financially, fit the profile and simply can't afford 12. YMMV The following user(s) said Thank You: rohcvfighter, Mnem | |
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