emo Any other geno 3, F4's doing/done treatment?

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6 years 7 months ago #5663

Is definitely a type of chemo fox, has been used to treat melanomas and has been trialled with other cancers.


GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26

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6 years 7 months ago #5763

Browny here

I got a great parcel in the mail at the end of last week and started treatment on the weekend. Feeling absolutely fine apart from a weird chemical smell coming out of my body - will keep you posted on who the side effects and test outcomes.

Great news about the PBS listing - so many people are waiting and dying for these drugs - I couldnt be more chuffed about it.


Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

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6 years 6 months ago #10731

Browny here

Updating progress following test results following 1 month on declatisvir and sofosbovir.

Still detectable but viral loads are down from 5.8 Log 10 IU/ml to 1.2

ALTs are down from 26 to 12

Am experiencing tiredness and some nights with wakeful sleep but still going to work everyday. Also, still smelling very chemically.

Am thinking of doing 16 weeks but am would love to hear from those who have new evidence showing that longer is better.


Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

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6 years 6 months ago #10732

What is the actual number of your viral load?


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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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6 years 6 months ago #10733

Hec P RNA NAA was 6.4x10^5 and is now 15

I don't really understand the results very well .... (lol)!


Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

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6 years 6 months ago #10734

this also should read hep c not hec P !!!!!!!!!!!!


Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

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6 years 6 months ago #10735

Is it <15, or 15? Thanks.


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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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6 years 6 months ago #10743

Browny wrote:

Hec P RNA NAA was 6.4x10^5 and is now 15

I don't really understand the results very well .... (lol)!

Hi Browny,

The log figure means the first number times ten by the number of times the little number beside the ten shows. So in your case 6.4 multiplied by ten, five times or 6.4 x 10 x 10 x 10 x10 x10 = 640,000 In other words, your pretreatment test was 640,000.

I suspect your new result is probably less than 15, maybe shown as <15 just because 15 is a common cutoff point for a lot of these tests. Whichever it is, that's a good result for F3-4 at 4 weeks. :+1: :)


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:

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6 years 6 months ago #10945

Thanks Gaj and all

I looked at the test result and it is just 15 (no < or >).

I was a bit bummed at first because so many people on this site and the few people I know were undetectable after 4 weeks - but yes, the reduction in viral load and improvement in ALTs are all good.

I just wanted to share my experience for others out there who might be in similar situations.


Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec
The following user(s) said Thank You: Gaj

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6 years 6 months ago #10954

We have 33.5% cirrhosis patients in the group we are tracking. This is much higher than most of the published clinical trials.

What we observe is that F3/F4 patients do take longer to reach undetected.

In Gilead's trials <25 was what was used so you would have been <25 detected, rather than 15 detected at 4 weeks, so it is in line with expectations.

It will go to undetected, maybe through <15, but undetected should really read <10 or <8 because this is closer to the real meaning.

With F4 GT3 you do need 24 weeks treatment to deliver a 90% SVR rate.

Ketogenic diet, B12 and Vit D may assist, but that's speculative at the moment. The "energy slump" some patients get about a month into treatment does seem to respond to B-B-Berocca.

I would not worry too much. It's not the millions of die easy HCV virions that cause relapse. It's the handful of resistant mutants that we simply can't measure.

The observation of slower response does suggest why the extended treatment time is required for F4 GT3


YMMV
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6 years 6 months ago #10957

Hi,
I'm geno 3 F4, I just got my VL back after 12 weeks tx- is under 15 but still detected- I have 24 weeks to take altogether and can see how important that is for those of us in this category.


Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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6 years 6 months ago #10983

I just got my 4 week VL test back today. <15. :)


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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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6 years 6 months ago #11057

#woohoo! Great news :)


G2B - DIAGNOSED 2014, STARTED SOF/DAC 11/11/15 VL 6M
UND @ WEEK4
FINISHED TREATMENT 26/4/16
UND @ WEEK 24
ALT 12 AST 15
MY ETERNAL GRATITUDE TO GREG JEFFERYS & DR FREEMAN
The following user(s) said Thank You: splitdog

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6 years 6 months ago #11120

Just heard back from the clinic with my 12 week VL results, big drum roll...........

Not Detected!!! :woohoo:


:+1: A big "Thank You!" to Dr James and all of the people behind the scenes at FixHepC who made this possible. :+1:


G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 6 years 6 months ago by Gaj.
The following user(s) said Thank You: DrJames, Chejai, Another Attempt, Jaz

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6 years 6 months ago #11124

GAJ Congratulations, such a great feeling right!
I've been waiting to hear this news from you.
#duck #duck #duck #duck #duck #duck


gt 1a VL 6m
F2/3 FibroScan - 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
Last Edit: 6 years 6 months ago by pat1.
The following user(s) said Thank You: Gaj

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