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Ledifos now available 8 years 6 months ago #3730

  • emilio
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Hi everyone

I think we should be concentrating on existing supply chains and of course emerging ones.

However making guesses on whether a snapshot of random product is legitimate or otherwise could be misleading for desperate folk. In the absence distributors comment and guarantee along with other evidence we need to be careful. Just saying. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
The following user(s) said Thank You: Chapel, Gaj

Ledifos now available 8 years 6 months ago #3749

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24

Ledifos now available 8 years 6 months ago #3751

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Hi Dabara

I wasn't questioning the validity of the planned generic drugs that are about to come out of India, it was more to do with random pictures which none of us can verify 100% without additional evidence. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

Ledifos now available 8 years 6 months ago #4503

HYDERABAD, DEC 8:
Generic pharmaceuticals and anti retroviral drug manufacturer Hetero has received approval for the fixed dose combination drug Ledipasvir sofosbuvir from the Drug Controller General of India (DCGI).

The drug, Ledisof, is a generic version of Gilead Sciences’ brand Harvoni which is approved by the US FDA.

The Hyderabad based Hetero had singed a non-exclusive licensing agreement with Gilead in September last year to manufacture and market the drug indicated for the treatment of chronic hepatitis C and is the first company to receive DCGI approval for this category of drug.

``We are happy to extend the fixed dose combination therapy Ledipasvir sofosbuvir (Ledisof) to Indian patients which is much more effective than Sofosbuvir,’’ B P S Reddy, Chairman and Managing Director of Hetero said in a release issued here on Monday.

Hepatitis C is a growing health concern in many developing countries including India which is estimated to have about 12 to 18 million people infected with hepatitis C.

(This article was published on December 8, 2015)
Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
The following user(s) said Thank You: Enkel

Ledifos now available 8 years 6 months ago #4504

  • Enkel
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Hetero is a reputable company. Hetero has revenues over $1 billion and reported a profit of $100 million in last fiscal year. I really dont understand these doctors who dont believe in these big companies.
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
The following user(s) said Thank You: Gaj

Ledifos now available 8 years 6 months ago #4508

Enkel,

I am not sure it is because the doctors don't rate the companies involved. After all, the UK NHS uses generics from these companies for about 40% of their scripts I believe. They wouldn't do that if they thought the companies were rubbish.

So go figure.

dt

Ledifos now available 8 years 6 months ago #4510

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Considering that Gilead takes the APIs from Jordan, I would say that Ledifos is original and Harvoni is generic :lol:
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured

Ledifos now available 8 years 6 months ago #4518

Wasn't it supposed to be Ledifos and not Ledisof...?

www.business-standard.com/article/pti-st...-115120800640_1.html

It says on Ledifos bottle that it is only for sale in India, so the same as Ledisof (for Indian patients only) - so really don't understand why hetero now needs two different brand names for the same product to be manufactured for Indian patients only...?
Lisof is for Nepali market only...

Ledifos now available 8 years 6 months ago #5011

  • Enkel
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One more time is Ledifos, not Ledisof


Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
Attachments:

Ledifos now available 8 years 6 months ago #5013

One company cannot market the same drug under two different brand names on the same market (Indian). So it has to be a typo in the official announcement made by hetero....?

heteroworld.com/view_news.php?id=460

Ledifos now available 8 years 6 months ago #5014

  • Enkel
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typo the persons who write on web are not pharmacist
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured

Ledifos now available 8 years 6 months ago #5015

I really doubt that it is a typo as it's been already 4 days since the announcement was out. They would've already changed it to Ledifos. But let's see...
Ledisof mentioned 3 times in the announcement - so 3 times typo) 2nd biggest pharm company in India :whistle:

Ledifos now available 8 years 6 months ago #5016

  • Enkel
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the bottle above has the production date dec 2015. So it is typo 100%
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured

Ledifos now available 8 years 6 months ago #5058

I have found misspellings and incorrect grammar are common in India.
It is certainly a typo.

Ledifos now available 8 years 6 months ago #5059

I just received a reply from a pharmacy in India that they can now ship to me Ledifos. The price is $395 USD. The company does business as Medsure (www.medsure.in/about-us.html) as well as New Global Enterprises. The fellow in charge is: Vivek Ramteke (91-9096843768). I don't understand how he can ship now as I have not heard yet that the generics can be sold in India. Has anyone heard of Vivek Ramteka?
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