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New trial study of genotype 3s 8 years 5 months ago #2892
From a presentation at the latest AASLD conference: www.hcplive.com/conference-coverage/aasl...gimen-for-genotype-3 | |
New trial study of genotype 3s 8 years 5 months ago #2909
So, the new ALLY 3+ is different to ALLY 3 because of the sign (+) that stands for Riba addition to the double DAA tx ? From the article: "Hepatitis C’s genotype 3 can be hard to cure, but researchers presenting a study at the Liver Meeting (AASLD) in San Francisco, CA, said they have found a regimen that works. Vincent LeRoy, MD, of the Centre Hospitalier Universitaire de Grenoble, La Tronche France, and colleagues at other institutions reported on a trial known as ALLY-3+. Fifty patients with HCV-GT-3 were treated and most had already had other treatments. The patients got daclatasvir (Daklinza/Bristol-Myers-Squibb) sofosbuvir (Sovaldi/Gilead) and ribavirin (Rebetol/Merck). One arm of the group got the combo for 12 weeks and showed SVR4 rate of 88%. A second group took the drugs for 16 weeks and their SVR4 rate was 96%. There were no virologic breakthroughs. In an abstract presented at the meeting, the team concluded that the combination therapy “Achieved high SVR4 rates” in patients with HCV GT3 with compensated advanced fibrosis or cirrhosis “and was generally safe and well tolerated.” Geno 3, Fibro 8.7 pKA, tx experinced in 2005 - Peg/Riba, relapsed. Started tx 1/12/2015 with Indian Sofo & Chinese Dac. 5 weeks result all normal, ALT 18 - down from ALT 73 at the start of tx. 5 weeks HCV PCR RNA - UND. - down from 2 ML 9 weeks HCV PCR RNA - UND. The following user(s) said Thank You: Chejai | |
New trial study of genotype 3s 8 years 5 months ago #2958
| The extra 4 weeks makes a difference then ? Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV |
New trial study of genotype 3s 8 years 4 months ago #5506
Oh, so now I see that was what Dr James was referring to in my appointment last week. I'm G3a, F0-F1, he's prescribed the Sof/Dac but said instead of the usual 12 weeks I should do 16 weeks because the SVR4 had higher rate of success in recent research. Thanks for that article. QLD Australia ☀️ G3a HCV 35 yrs Tx naive Started Sof/Dac 13/01/16 Dec '15 AST 70 ALT 89 GGT 124 Fibroscore 8.5 F1-F2 13 Feb'16 VL UND AST 24 ALT 26 GGT 50H | |
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