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HCV New Drugs Blogspot 7 years 11 months ago #15858
Sorry to hear of your friend, it must be so difficult being stuck in that situation. While DAAs themselves are unlikely to reduce fibrosis on their own, there is considerable research and clinical trialling going on of other medications that do target fibrosis reduction in the liver and other areas. Some of the research and trials are quite advanced so hopefully we will get some good news soon. www.ncbi.nlm.nih.gov/pmc/articles/PMC4515973/ www.monash.edu/__data/assets/pdf_file/00...drug-development.pdf G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
HCV New Drugs Blogspot 7 years 11 months ago #15860
Gaj, I sort of quoted that part... "We demonstrate that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation and that inactivation of CB1 exerts potent antifibrotic effects in inflammation-driven models of fibrosis." www.ncbi.nlm.nih.gov/pubmed/20617520 His doctor said "interferon increases the adhesion of fibroblasts to fibronectin " as the cause of Peyroni's. P. | |
HCV New Drugs Blogspot 7 years 11 months ago #15861
The "in inflammation-driven models of fibrosis" part of the original text is important to context. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
HCV New Drugs Blogspot 7 years 11 months ago #15866
Wednesday 5/11/16 5 Things You Should Know About Dietary Supplements for Hepatitis C hepatitiscnewdrugs.blogspot.com/2016/05/...w-about-dietary.html Alcohol accelerates liver damage in people living with hepatitis C hepatitiscnewdrugs.blogspot.com/2016/05/...liver-damage-in.html Janssen to Start a Phase IIb Study/Combinations of Simeprevir, Odalasvir and AL-335 for the Treatment of Hepatitis C hepatitiscnewdrugs.blogspot.com/2016/05/...se-iib-study-of.html Public Reporting Measures Fail to Describe the True Safety of Hospitals hepatitiscnewdrugs.blogspot.com/2016/05/...easures-fail-to.html This email address is being protected from spambots. You need JavaScript enabled to view it. forums.delphiforums.com/generichcvtx G 1a F-1 Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil 11/17/15 4 wk lab ALT 17 AST 16 <15 11/18/15 Started Harvoni 12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND 1/14/16 Fin. Tx 7/07/16 UND SVR 24 | |
HCV New Drugs Blogspot 7 years 11 months ago #15872
Thanks for posting. That's very interesting, but not the complete story imnsho. Supplements may not fix your liver or reduce your VL but the virus impacts other things as well. Your liver, immune system, digestion etc are compromised and that's where supplements can help. Genotype 1a Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!! Harvoni treatment, started 19 March 2016 4 week results Bilirubin 12 down from 14 pre treatment, Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47, VL <15 down from a lazy 6 million or so EOT Results Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND 12 Weeks post EOT Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND Cured baby The following user(s) said Thank You: mgalbrai, Matt-Kenney-google | |
HCV New Drugs Blogspot 7 years 11 months ago #16177
The curious case of generic sofosbuvir: hepatitiscnewdrugs.blogspot.com/2016/05/...-hep-c-drug.html?m=1 This email address is being protected from spambots. You need JavaScript enabled to view it. forums.delphiforums.com/generichcvtx G 1a F-1 Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil 11/17/15 4 wk lab ALT 17 AST 16 <15 11/18/15 Started Harvoni 12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND 1/14/16 Fin. Tx 7/07/16 UND SVR 24 | |
HCV New Drugs Blogspot 7 years 11 months ago #16179
Cheers Mike. I visited the comments section, left my piece Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716 | |
HCV New Drugs Blogspot 7 years 11 months ago #16210
Concerning the high price of HCV treatment: hepatitiscnewdrugs.blogspot.com/2016/05/...ling-us-how-can.html Gilead Sciences' patent on hepatitis C drug sofosbuvir challenged in Delhi High Court hepatitiscnewdrugs.blogspot.com/2016/05/...-on-hepatitis-c.html This email address is being protected from spambots. You need JavaScript enabled to view it. forums.delphiforums.com/generichcvtx G 1a F-1 Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil 11/17/15 4 wk lab ALT 17 AST 16 <15 11/18/15 Started Harvoni 12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND 1/14/16 Fin. Tx 7/07/16 UND SVR 24 | |
HCV New Drugs Blogspot 7 years 11 months ago #16212
| WOWZERZ Mike! Concerning the high price of HCV treatment: The article was interesting, but the "comments" were incredible! I couldn't keep up with a lot of it. Thanks for sending these posts along ... GT1a; Got it some time in the 70's; Diagnosed @1976 Tx naive METAVIR: A2-F2 SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000 3 weeks after SOT: AST 27 ALT 31 VL 138 Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24 Hep C RNA "NOT DETECTED" AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24! The following user(s) said Thank You: mgalbrai |
HCV New Drugs Blogspot 7 years 11 months ago #16222
I commented on the patent challenge story, will see if it makes it past moderator. Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716 | |
HCV New Drugs Blogspot 7 years 11 months ago #16225
Matt yes these links are useful I'm in the habit of emailing the ones most relevant to myself and I folder them as a resource for my lobbying This corner of the forum has a lot of relevant info I'm fussy about biases and dates and so also check who the author is of any links etc but that's just me. Mostly links are relevant and excellent education. Cheers and yes I agree ty Mile again for the research Ariel PS Hazel your comment is there xxx I read it ty Gen 1a Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas. pre sof/led VL 240,000 Fibsc F0 Day 25 <30 Day 32 UND Week 10 UND EOT UND ALT11AST17GGT19 SVR4 UND ALT10 AST16 GGT13 SVR8 UND ALT <9 AST16 GGT15 SVR12 UND ALT14 AST19 GGT12 Bili 5 EOT +18 ALT13 AST20 GGT9 Bili 5 EOT +21 ALT11AST15 Cured SVR12 Dysplasia Adenomas RemvdAug '16 SVR24 UND ALT11AST16 ColonoscopyClear Nov17 LumpectomyClear ‘18 LithotripsyCytoscopyBiopsy 4/18 | |
HCV New Drugs Blogspot 7 years 11 months ago #16228
| Hi Ariel, I love most all of the posts here and throughout the forums. Very educational and helpful Great idea. I'm stealing it GT1a; Got it some time in the 70's; Diagnosed @1976 Tx naive METAVIR: A2-F2 SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000 3 weeks after SOT: AST 27 ALT 31 VL 138 Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24 Hep C RNA "NOT DETECTED" AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24! |
HCV New Drugs Blogspot 7 years 11 months ago #16230
| The comments posted on that site are useless! I posted some info about TPP recently. It looks like "they" are going to ignore/suppress info concerning generics. Gilead has a patent! In the 1st world countries, the health systems will not embrace generics for 20 years! They can't, we have patent laws. All these people pissing and moaning about greedy pharma, while valid, accomplish nothing! It is the clandestine access to generics that is real - why we are all here. Push this site, the Redemption trials or Incepta and their This email address is being protected from spambots. You need JavaScript enabled to view it. email. As Dr. Freeman has stated, time may be short for access. The mainstream access will be decided by TPP. TPP is a done deal folks. It's going to happen. My insurance company (Blue Cross/Blue Shield of Florida) was hoping I would die before they had to give me treatment! They wanted me to wait until I was on the transplant waiting list (F4) Incepta is who helped me! Anyone wanting treatment has to spend their own money and get treatment. $1000 for a cure seems reasonable to me. Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 |
HCV New Drugs Blogspot 7 years 11 months ago #16232
| GT1a; Got it some time in the 70's; Diagnosed @1976 Tx naive METAVIR: A2-F2 SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000 3 weeks after SOT: AST 27 ALT 31 VL 138 Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24 Hep C RNA "NOT DETECTED" AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24! |
HCV New Drugs Blogspot 7 years 11 months ago #16233
| Matt-Kenney did you get your meds? What make did you get? Let everyone know!! Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 |
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