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HCV New Drugs Blogspot 7 years 9 months ago #15858

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Sorry to hear of your friend, it must be so difficult being stuck in that situation. While DAAs themselves are unlikely to reduce fibrosis on their own, there is considerable research and clinical trialling going on of other medications that do target fibrosis reduction in the liver and other areas. Some of the research and trials are quite advanced so hopefully we will get some good news soon.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4515973/

www.monash.edu/__data/assets/pdf_file/00...drug-development.pdf
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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HCV New Drugs Blogspot 7 years 9 months ago #15860

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Gaj,
I sort of quoted that part...
"We demonstrate that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation and that inactivation of CB1 exerts potent antifibrotic effects in inflammation-driven models of fibrosis."

www.ncbi.nlm.nih.gov/pubmed/20617520

His doctor said "interferon increases the adhesion of fibroblasts to fibronectin " as the cause of Peyroni's. :blush:

P.

HCV New Drugs Blogspot 7 years 9 months ago #15861

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The "in inflammation-driven models of fibrosis" part of the original text is important to context.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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HCV New Drugs Blogspot 7 years 9 months ago #15866

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Wednesday 5/11/16

5 Things You Should Know About Dietary Supplements for Hepatitis C
hepatitiscnewdrugs.blogspot.com/2016/05/...w-about-dietary.html

Alcohol accelerates liver damage in people living with hepatitis C
hepatitiscnewdrugs.blogspot.com/2016/05/...liver-damage-in.html

Janssen to Start a Phase IIb Study/Combinations of Simeprevir, Odalasvir and AL-335 for the Treatment of Hepatitis C
hepatitiscnewdrugs.blogspot.com/2016/05/...se-iib-study-of.html


Public Reporting Measures Fail to Describe the True Safety of Hospitals
hepatitiscnewdrugs.blogspot.com/2016/05/...easures-fail-to.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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HCV New Drugs Blogspot 7 years 9 months ago #15872

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Thanks for posting.
That's very interesting, but not the complete story imnsho.
Supplements may not fix your liver or reduce your VL but the virus impacts other things as well. Your liver, immune system, digestion etc are compromised and that's where supplements can help.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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HCV New Drugs Blogspot 7 years 9 months ago #16177

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The curious case of generic sofosbuvir:

hepatitiscnewdrugs.blogspot.com/2016/05/...-hep-c-drug.html?m=1
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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HCV New Drugs Blogspot 7 years 9 months ago #16179

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Cheers Mike. I visited the comments section, left my piece
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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HCV New Drugs Blogspot 7 years 9 months ago #16210

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Concerning the high price of HCV treatment:

hepatitiscnewdrugs.blogspot.com/2016/05/...ling-us-how-can.html



Gilead Sciences' patent on hepatitis C drug sofosbuvir challenged in Delhi High Court
hepatitiscnewdrugs.blogspot.com/2016/05/...-on-hepatitis-c.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: Ariel, Gaj, beaches, Matt-Kenney-google, Meg

HCV New Drugs Blogspot 7 years 9 months ago #16212

WOWZERZ Mike!
Concerning the high price of HCV treatment:

The article was interesting, but the "comments" were incredible! I couldn't keep up with a lot of it. :blink: Sure are a plethora of ideas out there heh.
Thanks for sending these posts along ... :+1:
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
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HCV New Drugs Blogspot 7 years 9 months ago #16222

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I commented on the patent challenge story, will see if it makes it past moderator.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
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HCV New Drugs Blogspot 7 years 9 months ago #16225

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Matt-Kenney-google wrote: WOWZERZ Mike!
Concerning the high price of HCV treatment:

The article was interesting, but the "comments" were incredible! I couldn't keep up with a lot of it. :blink: Sure are a plethora of ideas out there heh.
Thanks for sending these posts along ... :+1:


Matt yes these links are useful
I'm in the habit of emailing the ones most relevant to myself and I folder them as a resource for my lobbying
This corner of the forum has a lot of relevant info
I'm fussy about biases and dates and so also check who the author is of any links etc but that's just me.
Mostly links are relevant and excellent education.
Cheers and yes I agree ty Mile again for the research
Ariel

PS Hazel your comment is there xxx I read it ty
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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HCV New Drugs Blogspot 7 years 9 months ago #16228

Hi Ariel,
I love most all of the posts here and throughout the forums. Very educational and helpful :) As an example your sharing the fact that you've made an email folder for personal use and to share with those who may not be as up to date on what's going on around them ... ;)
Great idea. I'm stealing it B)
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
The following user(s) said Thank You: mgalbrai, Ariel, beaches, Tricia

HCV New Drugs Blogspot 7 years 9 months ago #16230

The comments posted on that site are useless!

I posted some info about TPP recently. It looks like "they" are going to ignore/suppress info concerning generics. Gilead has a patent! In the 1st world countries, the health systems will not embrace generics for 20 years! They can't, we have patent laws. All these people pissing and moaning about greedy pharma, while valid, accomplish nothing! It is the clandestine access to generics that is real - why we are all here. Push this site, the Redemption trials or Incepta and their This email address is being protected from spambots. You need JavaScript enabled to view it. email. As Dr. Freeman has stated, time may be short for access. The mainstream access will be decided by TPP. TPP is a done deal folks. It's going to happen. My insurance company (Blue Cross/Blue Shield of Florida) was hoping I would die before they had to give me treatment! They wanted me to wait until I was on the transplant waiting list (F4) Incepta is who helped me! Anyone wanting treatment has to spend their own money and get treatment. $1000 for a cure seems reasonable to me.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
The following user(s) said Thank You: mgalbrai, beaches, Tricia, Matt-Kenney-google

HCV New Drugs Blogspot 7 years 9 months ago #16232

That's freedom of the press for you eh GF
. Well said, on getting treatment you need, where you can, at a price that makes some sense :+1: ;)
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
The following user(s) said Thank You: mgalbrai, beaches, Tricia, Greedfighter

HCV New Drugs Blogspot 7 years 9 months ago #16233

Matt-Kenney did you get your meds? What make did you get? Let everyone know!!
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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