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isaing4 Twinvir story 6 years 10 months ago #8641

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If my viral load is not UND at 6 weeks, half treatment...
Maybe it is recommended to prolonged the treatment with 4 weeks, with a total of 16 weeks?
I don't know, I am a little bit disappointed. :unsure:
Any advice will be appreciated.
Thanks! :)
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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isaing4 Twinvir story 6 years 10 months ago #8642

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I know from
fixhepc.com/forum/viral-load-and-svr/287...ct.html?limitstart=0
that after 8 weeks I have a big chance of UND.
But if not, maybe I must continue the treatment more then 12 weeks.
So I have to arrange to buy the medication as soon as possible.
Dr. James please consider my question if you have some little time. :dry:
Thank you so much! :)
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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isaing4 Twinvir story 6 years 10 months ago #8644

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If it cost low, make one at 6 week at another Lab. Delaying the viral load for 2 weeks I suspect it. To be detected at 4 weeks is normal but 83 I have not heard.....
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
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isaing4 Twinvir story 6 years 10 months ago #8650

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Hi Enkel,
Thanks! Good idea to test at another lab! B)
But at this one I have 50% discount.
Maybe I will try another lab at 8 weeks! :lol:
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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Last edit: by isaing4.

isaing4 Twinvir story 6 years 10 months ago #8652

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I'm going tomorrow for my 7 weeks VL test. Fingers crossed, I will get UND. Otherwise, will get some Indian generic tablets for additional 4 -6 weeks.
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
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Last edit: by Dan.

isaing4 Twinvir story 6 years 10 months ago #8653

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Hi isaing4 Thankyou for your really great data in your blog and your questions they are very helpful to many people incl myself here on only Day 8. I know of a few people who have done all extra six weeks
I also hear that some are still detected at 4 weeks but clear later on
It seems that the aim of achieving an SVR isn't tightly linked to the four weeks result to my thinking
Wishing us all our SVR hang in there all
Cheers from Ariel PS sorry for the late reading of your story I am relatively new to the forum #flower
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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isaing4 Twinvir story 6 years 10 months ago #8665

Hi Isaing - Do I read correctly that your VL came down from 9 million?
(Can't see your Profile while typing this on small device, so much more tricky keeping up since big comp. out of action)
If so, that may explain your result somewhat?
it would have come down quite alot!
Agree with Ariel over this, I've even read some people have been detected at EOT only to clear and know of someone personally who was 15 at EOT and went on to clear, so it could well be worth checking at another lab in 2 weeks.
Agree also, be prepared,just in case, but that's a magnificent drop really, 9 mil to 83 .
Wishing you all the very best for success and get those Bs & Ds down you :-) #love
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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Last edit: by LondonGirl.

isaing4 Twinvir story 6 years 10 months ago #8722

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Dan wrote: I'm going tomorrow for my 7 weeks VL test. Fingers crossed, I will get UND. Otherwise, will get some Indian generic tablets for additional 4 -6 weeks.

Good luck and........UND :lol:
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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isaing4 Twinvir story 6 years 10 months ago #8725

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Thanks Ariel the mermaid, like your name :)
Thanks LondonGirl, good choice also for your name, remind me of being spontaneous and young :)
It is a big drop from 9.000.000 to 83 in 4 weeks. Those bastards were so many and they were feeling so good inside my liver/body.
I was a polite host, but not anymore! :evil:
Generally, I think positive and I am an optimistic. B)
Happy with my progress toward regaining my health! :cheer:
All the best and UND soon to everyone of you!
#duck #duck #duck #duck #duck #duck #duck #duck #duck
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
This email address is being protected from spambots. You need JavaScript enabled to view it.
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Last edit: by isaing4.

isaing4 Twinvir story 6 years 10 months ago #8731

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Heh you are right, isaing! The bastards were indeed many - and most have been decimated now, only the more persistent stragglers left

As LG says, you can have detectable levels at EOT and still go on to achieve SVR, so I wouldn't be worrying at 4 weeks. Easy to say I know, when you read of others getting UND by that time. But there's still a long way to go :)
GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26
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isaing4 Twinvir story 6 years 10 months ago #8738

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We are in the same boat, Isaing. I also had a 9 million v/l and have not reached undetected at the 4 week test. Still waiting on the v/l results.

Hopefully it will not take much longer for us both. At 83 you are getting close! :)
3a F0 TX Naive
Started Tx 12/12/2015 Kingswood Sof/Dac

Pre Tx - ALT 71 AST 40 V/L 9 million
Day 11 - ALT 12 AST 15
4 week - LFTs normal - detected (same sample sent for v/l showed undetected) :/
6 week - UND
12 week EOT - UND
SVR4
SVR12
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isaing4 Twinvir story 6 years 10 months ago #8742

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Jaz what was your VL in number?
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured

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isaing4 Twinvir story 6 years 10 months ago #8746

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When they did my test they did not ask for viral load, only detected/undetected. After the test came back detected the nurse requested the sample to be re-tested for viral load.

The qualitative test (detected/undetected) is cheaper, it is done locally and is fairly quick. The viral load (quantitative) is more expensive and has to be sent to another state and can take 1-2 weeks.
3a F0 TX Naive
Started Tx 12/12/2015 Kingswood Sof/Dac

Pre Tx - ALT 71 AST 40 V/L 9 million
Day 11 - ALT 12 AST 15
4 week - LFTs normal - detected (same sample sent for v/l showed undetected) :/
6 week - UND
12 week EOT - UND
SVR4
SVR12
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Last edit: by Jaz.

isaing4 Twinvir story 6 years 10 months ago #8771

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Isaing, sorry I have not left you any well wishes on your thread yet!
Huge drop and heres wishing for an UND for you soon!
All the best
Deb #love #duck #flower
Geno 1a, F1, tx naive, had it 35 yrs.
Started Cipla HepcvirL on 12/01/16
Starting VL 490,000
At 16 days in <15
4 week results: UND
8 week results: UND
5 weeks EOT alt 25
SVR 15 - Not Detected
6 months EOT - Not Detected
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isaing4 Twinvir story 6 years 10 months ago #8789

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If my viral load is not UND at 6 weeks, half treatment...
Maybe it is recommended to prolonged the treatment with 4 weeks, with a total of 16 weeks?
I don't know, I am a little bit disappointed. :unsure:
Any advice will be appreciated.
Thanks! :)


You are 1b F0-1 and treatment naive. That gives you a 99% chance of SVR with 12 weeks Sof/Led:

ION-1 100% (67/67) ION-3 98% (43/44) Aggregate 99.1% (110/111)

Not bad odds.

To reassure you here are some real results from a patient of mine...

Week 0 7.8 million
Week 2 598
Week 4 76
Week 5.5 < 15
Week 8 0
Week 12 0
SVR 4 0
SVR 12 0

Lots of testing because she was a doctor and one of my first patients. 5.5 weeks because she went on a cruise!

Personally if I wanted an insurance blanket I would add some Simeprevir rather than treat for longer. The odds are on your side and you are chasing the last 1-2%.

fixhepc.com/forum/experts-corner/602-100...mpossible-dream.html
YMMV
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