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Hep C 3 treatment 7 years 2 days ago #737

Hi, I was hoping someone could tell me how to go about procuring a 24 week supply of daclatasvir and sofosbuvir given that I'm only allowed to import a 12 week supply?, I assume the 24 week course would need to be taken without interruption of medication, can someone shed any light on this dilemma?, the only logical play out of this scenario to me would be to stockpile the first 12 week supply and then import the second 12 week course after the original 3 month medication was due to be used up?,

i also would like to applaud the team at 'FixHepC' , I and many more now have a reason to hope, I put no faith in cabinet approval for a PBS listing, and who could blame them at the price the pharmaceutical companies are asking.
GT 3, F3, Contracted 1993 Tx Naive
V/L 1,267,000 AST 67 ALT 65 6/10/15
commence Sof/Dac (Mesochem) 6/11/15
AST ALT normal 24/11 *
*V/L UNDETECTED 24/11*
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Hep C 3 treatment 7 years 2 days ago #738

You can import three months at a time. This does not mean you have to wait three months to import your next lot.

No issue my friend. As Meso have closed their doors to individual supply I would imagine Fixhepc will be your provider. In that case I think you will find they have this issue under control

If you are using Indian sofosbuvir through Greg Jefferys then the same would apply.
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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Last edit: by Johnboy.

Hep C 3 treatment 7 years 2 days ago #750

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Hi Vicki,
I'm not sure about supplements. My nurse was going to check with the pharmacist about vit D and calcium I am prescribed but for now I've stopped taking them just in case.
I think Dr Freeman is the best person to ask this question.
Virus not detected from 14.10.2015
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Hep C 3 treatment 7 years 2 days ago #765

Funny you mention magnesium calcium and vitamin D

I am not a believer in artificial vitamins, especially vitamin D. You can not synthesise sunshine IMO. I also believe it is not Vit D but D2/3. I believe they are carcinogens.

Here is something for you to think about:
The chlorphyll molecule and the red blood molecule are identical except they have different central atoms. Chlorophyll has a central atom of Magnesium, red blood has a centre of iron. Green "plant blood" is changed to red human blood cells by the action of sunshines voltage on the skin. The by product of this process is calcium. So you see all these things are connected directly. What you need is more sunshine and more raw fresh greens in your diet. It's the natural way to build red blood cells, get magnesium, get calcium and get the correct vitamin D.

This is a very basic description but hopefully it entice you to find your healing in the way nature provides.

Green is your medicine. Sunshine is your friend.
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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Hep C 3 treatment 7 years 2 days ago #768

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Unfortunately I live in the UK and already have osteopenia. Low vit D level is associated with the Hep C. Hopefully once the virus is gone, my vit D level will go up.
Virus not detected from 14.10.2015

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Hep C 3 treatment 7 years 2 days ago #770

Sunshine is indeed my friend, but also in UK. The sunshine here is not good enough, if we see it at all ! We can get cheap flights to warmer climates easily, I need my VitC fix frequently and always feel a huge improvement. Last bloods, my VitD result showed just enough, that was after taking suppliments over last winter.

Magnesium is a v interesting one, it seems to help many ailments associated with HepC. Although my Dr said it was 'unlikely' I have found it has helped me personally.

Edit: Please note I am not on treatment, would also be interested in DrF's take on that
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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Last edit: by LondonGirl. Reason: addition

Hep C 3 treatment 7 years 2 days ago #771

A site you may get help from.It's not all things but is pretty extensive. I check "view all" to navigate.
www.hep-druginteractions.org
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Hep C 3 treatment 7 years 2 days ago #772

There is a very handy app which is great too. It cross references many drugs for interactions with HepC meds.

It is called "Hep Ichart"

It is from the the university of Liverpool
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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Last edit: by Johnboy.

Hep C 3 treatment 7 years 2 days ago #778

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I'm hearing you Johnnboy, I eat so much fresh green from my garden. I get a fair bit of sunshine here on the on the South Coast of Australia.

I'm not big on supplements but since taking manesium my nasty migraines have abated.
I can get a rub on magnesium rub on gel (though expensive)

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Hep C 3 treatment 7 years 2 days ago #779

Whatever works for you has got be good eh!

If I had migraines I would take anything that worked too :)
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015

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Hep C 3 treatment 6 years 11 months ago #989

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Hi all,

I'm 2 1/2 weeks into Sof/Dac 12week treatment. So far so good. :)

I'm wondering about times to take the Sof/Dac?
Right now I'm taking both the Sof and Dac together in the morning with a light healthy breakfast.
I saw mention that Dr. Freeman had published a page on this site about foods to avoid when you take your cure.
I can't seem to find it
I have thoroughly read the "Consumer Medication" directions and they don't mention diet.

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Hep C 3 treatment 6 years 11 months ago #992

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Hello Vicky, this is Life!!! :)

So you take both at the same time in the morning, is that correct?

Thanks for replying!!!

Ohw, I see that you asked the same question...i'm also looking for the foodlist, I'm starting on monday!!

Thanks

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Hep C 3 treatment 6 years 11 months ago #995

Hi Vicki,

The big NO NO with Dac is Grapefruit juice which inhibits the enzyme CYP3A4 which breaks down the Dac. As a result of this inhibition the Dac levels build up, as do the sides.

You may find this page helpful

www.ganfyd.org/index.php?title=Inhibitors_of_CYP3A4

Here's Wikipedia's overview of it en.wikipedia.org/wiki/CYP3A4
YMMV
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