Hi Doc Freeman,
There was a school of thought, I am sure you are aware, that advocated using your biggest guns up front in a tx. The thinking was to kill off as many resistant mutations as possible before they became emergent. From a virology point of view this made sense to me.
If I read you right, you are reasoning that adding riba at the end, not the beginning, could make it more tolerable, both physically and psychologically, especially for an F4 situation. This also makes sense to me.
So, if tolerability is not an issue, say somebody is F1, all blood tests normal, what would you do? Hammer the virus at the beginning to try and prevent any stray hangers on, or hammer it at the end to finish them off?
Thanks, dt