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Dac and Led interactions 8 years 4 months ago #6392
I have been looking at the prescribing information here: fixhepc.com/forum/forum-gp-cheat-sheet.html "Medications (Daclatasvir and Ledipasvir in particular have many interactions) you can check with this tool www.hep-druginteractions.org/checker I checked with the tool and it is not showing any interactions for dac and led. It's giving a green light. So which is correct? Thanks, dt | |
Dac and Led interactions 8 years 4 months ago #6393
Oh duh! I see that the prescribing info meant that both dac and led have many interactions with OTHER drugs. I was thinking it meant they have many interactions with EACH OTHER. Anyway, I am still unclear on the subject of whether dac and led have interactions with each other. I cannot find any information which suggests that they do. I also cannot find any evidence which proves that they don't. I want to know if the concentration of either drug will be lowered by the presence of the other during a switchover from led to dac, while keeping sof the same? Possibly this is still one of the many as yet unanswered questions about using the DAAs. dt | |
Dac and Led interactions 8 years 4 months ago #6397
I suspect there is little research on what you are asking as: - It would require crosslabel trials which tend to be expensive. - the standard treatment approach seems to be to use one NS5A inhibitor thoughout treatment and if that treatment fails to retreat preferably using another NS5A inhibitor that expresses itself via a different path if such an drug exists. This would apparently reduce any risk of resistance effecting the retreatment. I don't know whether Dac and Led differ sufficiently to do that or whether they are entirely analogous. I'm not a scientist just an interested reader so the above is just my take on it. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The following user(s) said Thank You: dointime | |
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