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Mesochem APIs lumpy 7 years 4 months ago #7098

  • dointime
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This is one for those who encapsulated the Mesochem APIs themselves.

I've noticed that the sof is pretty lumpy and the lumps are hard to break down, not crumbly. The obvious answer is of course to put it through a sieve before encapsulating, but I don't remember the use of a sieve being mentioned in anybody's instructions.

So for those like me who started to encapsulate before realising that the api was all lumpy, my question is - does it matter? Will those lumps be digested just the same or will their absorbtion be hindered? The size of the lumps is what fits into a 00 capsule.

I note that the sof API is documented as not water soluble.

dt
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Mesochem APIs lumpy 7 years 4 months ago #7103

Hi dt,
Mine was powder-no lumps. I don't know what to say about disolving. I can't see why it wouldn't.

Maybe just weigh 400 mg of "lumps", get a shot glass of warm water,
dump in the lumps, see what happens, then toss that bad boy down.
You can chase it with the led or dac.
Did your powder come lumpy or get lumpy?
Mike
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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Mesochem APIs lumpy 7 years 4 months ago #7104

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Hi dt,

I put my sof in a bowl and mixed it for a while with an egg whisk till it came out as a more or less smooth powder.

If you encapsulated it with lumps I can't see it making any difference except to maybe digest a bit more slowly.
GT 1a
cirrhosis (or not, take your pick)
2015 - failed treatment with simeprevir+inteferon+ribavirin
23 Sep 2015 started 24 weeks treatment with Mesochem's sofosbuvir+ledipasvir
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Mesochem APIs lumpy 7 years 4 months ago #7105

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Hi Mike,

My powder came lumpy directly on opening the foil pack. Interesting that yours was not lumpy.
I stored it in a dry place with silica gel sachets at 70C, so no way it got lumpy with me. It's not humid either where I am.

Yeah, I guess I just have to do some experiments. What's a few lumps to us pioneers, eh? :)

dt
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Mesochem APIs lumpy 7 years 4 months ago #7106

Good luck DT - Pioneers is the word !
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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Mesochem APIs lumpy 7 years 4 months ago #7108

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We have seen literally hundreds of packages of Mesochem API. It is perfectly ground and lump free.

Sofosbuvir is hygroscopic (absorbs water) but I have some Mesochem API that is in a post testing and sitting in zip lock bags in the original open foil package. It has been on my desk for weeks. No lumps.

Send us a small (1/8th of a capsule) sample and we will test it.
YMMV
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Mesochem APIs lumpy 7 years 4 months ago #7116

Doc,
You are simply the BEST!!
Can you be my PCP?
m
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

Mesochem APIs lumpy 7 years 4 months ago #7117

  • Life
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I have lumps aswell, I broke down the small parts...Still have some big lumps don't want to use them. In my new package (4 weeks) no lumps..It seems that the texture of the powder changes....My new package is much softer again, like clouds-powder. Huhmn and the other package of Dac also different, other taste...
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Mesochem APIs lumpy 7 years 4 months ago #7118

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I feel like in the beginning of my TX (new 4 weeks)...High as a bird...same sensation as in the beginning...deffinately different texture after a period of time.....
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Mesochem APIs lumpy 7 years 4 months ago #7119

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I have seen the sofusbuvir like lumps only Alibaba web photos

www.alibaba.com/product-detail/high-puri...838.30.27.rt6NWX&s=p
Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
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Mesochem APIs lumpy 7 years 4 months ago #7137

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I have lumps as well, I broke down the small parts...Still have some big lumps don't want to use them. In my new package (4 weeks) no lumps..It seems that the texture of the powder changes....My new package is much softer again, like clouds-powder. Huhmn and the other package of Dac also different, other taste...


Please send samples for testing.
YMMV

Mesochem APIs lumpy 7 years 4 months ago #7158

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Hi Doc and thanks for the help. The Mesochem batch number of this sofosbuvir is BN15057157F, date 2015-8-13.
I presume I should send the sample to your GPO Box 391 address.
Will post immediately.
dt

Mesochem APIs lumpy 7 years 4 months ago #7161

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Life - So your sof changed texture after time. I received this package in September but have just opened it now. Maybe, as you say, it gets more lumpy after a time. Anyway, we'll see what the testing shows.
dt

Mesochem APIs lumpy 7 years 4 months ago #7166

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Doc Freeman -
What should be put on the package customs declaration for this one sof capsule I am sending for testing?
What carrier works best from UK for Tassie? fedex? DHL? UPS?
dt

Mesochem APIs lumpy 7 years 4 months ago #7192

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Just ordinary airmail works fine. I would just write "Medication for Testing" and print out a copy of the COA and MSDS from here and put it in the package: fixhepc.com/getting-treated/importing-fr...inese-suppliers.html

I have spoken with Rachel about it and it's almost certainly (literally) from the bottom of a 25 kg barrel where it gets compressed (just like in a pill press that makes tablets),

fixhepc.com/forum/experts-corner/548-lumps-in-api-powder.html

I'm sure it will be fine, but let's test it to provide reassurance.

As you can see Rachel is going to have words to the packers to make sure there are no more lumps.
YMMV
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