So what are the REDEMPTION eTrials?

So what are the REDEMPTION trials? 8 years 11 months ago #1402

Sirchinenge
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The reason The buyers club was offering an API from China as opposed to say
Twinvir is due to the fact they could not avail of Twinvir at that time.

An API is the active ingredients in the drug.

Twinvir or any other Generic is made from an API sourced from various countries
including China you are taking the equivalent of these drugs.

The only difference in how you purchased, you bought the drugs in raw form from
China. The buyers club takes your API tests it and then encapsulates them.

Encapsulating equals putting the API(Powder) into a capsule you can swallow.

You have nothing to worry about.

Note; The questions you both have are appreciated, this thread is going off Topic a such if you have questions about APIS
and the difference between various drugs please, put them in a separate thread.

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.

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So what are the REDEMPTION trials? 8 years 11 months ago #1403

DrJames
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Don't panic!

An API is what is known as the "Active Pharmaceutical Ingredient" ie Sofosbuvir or Ledipasvir.

If you take Gilead as an example the APIs for Harvoni are made in Jordan.

This chemical powder is then shipped to Ireland where the two parts are mixed with glue, lactose (milk sugar), fibre, disintegrant, sand, wax and pressed into tablets.

The extra bits are called excipients and can be used to control rate of release but in the case of Harvoni it's a fast release instant dissolution.

Harvoni Excipients:

Copovidone (glue)
Lactose monohydrate (sugar)
Microcrystalline cellulose (fibre)
Croscarmellose sodium (disintegrant)
Colloidal anhydrous silica (sand)
Magnesium stearate (wax)

What you have is the APIs mixed with Microcrystaline cellulose in a capsule that, like Harvoni releases the API rapidly. The other parts of the tablet are only used to make the table stick together, and then dissolve in your stomach. It's cheaper to make a tablet than a capsule which is why they are commonly used.

There are now hundreds of people now have taken Sofosbuvir/Ledipasvir in this form and are at viral load zero.

The APIs in both Twinvir and your medication came from China (different large scale factories). They are chemically identical the the APIs in Harvoni and you can read the testing reports about that here: Testing Provisions Patient Safety .

YMMV

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So what are the REDEMPTION trials? 8 years 11 months ago #1455

Vororo
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Hello Dr Freeman, Hello world!

Please can you explain the REDEMPTION trials a bit more? Is this essentially something that you are organising with The Club? Does it mean that you will be asking the members to send you their treatment results?

If so, I would like to say that this is really another GREAT INITIATIVE from Down Under, and it must be one of the best ways possible to show ordinary GPs that it is OK to prescribe DAAs... Me personally, I will be happy to participate (my own wire transfer to The Club went through a few days ago, I think...).

Lets all help to Bust the Scare-Mongering Myths About "Generics" and Buying From "Abroad"!!

Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
Week4: AST 47, ALT 58. VL < 15 (unquantifiable).
Week12 (EOT): AST 30, ALT 26, VL UND
Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND
Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND
Ever grateful to Dr James.

Relapsed somewhere after all that... Bummer!

Jan 2018: VL 63 000 (still GT3).

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So what are the REDEMPTION trials? 8 years 11 months ago #1470

LondonGirl
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Any idea when more info will be forthcoming Sirchinenge? Thx LG.

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

So what are the REDEMPTION trials? 8 years 11 months ago #1473

Sirchinenge
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The trials are simply to gather evidence that Generics do work they also provide
an opportunity to offer access to treatment to as many people as possible.

I don't think the plan is to add in anyone who has bought over the last few weeks.

Two reasons stand to mind; 1; The price point for the buyer club is not the same
as the Redemption Trials.
2; The Buyers club was only offering two drug options from one
source in China. The Trials are offering more drug choices from a variety of suppliers in Bangladesh.

What information are you looking for London Girl?

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.

The following user(s) said Thank You: LondonGirl

So what are the REDEMPTION trials? 8 years 11 months ago #1476

LondonGirl
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I don't know, I think there was mention of more details 'on Monday'? The time difference can be confusing too!

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

So what are the REDEMPTION trials? 8 years 11 months ago #1477

Sirchinenge
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fixhepc.com/forum/redemption/210-redempt...-incepta-pharma.html

fixhepc.com/forum/redemption/209-redempt...and-3-timelines.html

I think you're referring to the threads linked above which he added at the weekend he
obviously got around to it before today.

I don't think there's much to add at this juncture.

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.

The following user(s) said Thank You: LondonGirl

So what are the REDEMPTION trials? 8 years 11 months ago #1484

2b
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My question relates to the Corevigen single pill combo of daclatasvir and sofosbuvir that is to be used in the Redemption 2 trial, my question is does anyone know when that corevigen is going to be available?

GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"

So what are the REDEMPTION trials? 8 years 11 months ago #1486

2b
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Ok, just got that answered, looks like mid november target date, but only after thorough testing is complete and tests good.

GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"

So what are the REDEMPTION trials? 8 years 11 months ago #1568

Debs
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Hi Dr Freeman, here's hoping that consultants in the NHS will acknowledge this worldwide trial and will monitor treatment if a person is on it.
Also is there a limit to how many can go on the sof/led trial? Could I put my name down now?
Thanks, Deb

Geno 1a, F1, tx naive, had it 35 yrs.
Started Cipla HepcvirL on 12/01/16
Starting VL 490,000
At 16 days in <15
4 week results: UND
8 week results: UND
5 weeks EOT alt 25
SVR 15 - Not Detected
6 months EOT - Not Detected

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So what are the REDEMPTION trials? 8 years 10 months ago #2882

Nonna Offline New Member Posts: 9 Thank you received: 5	I think you would be just the man for the job Emilio. The trials sound like a great idea.