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Viral Load and SVR
Understanding SVR - Why don't we call it cure?
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Understanding SVR - Why don't we call it cure? 7 years 8 months ago #20819

You rock beaches :+1:
Nicely said. Thanks,

Matt
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
The following user(s) said Thank You: Ariel, Gaj

Understanding SVR - Why don't we call it cure? 7 years 8 months ago #20820

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Matt-Kenney-google wrote: You rock beaches


Oh, you're gonna be in so much trouble Matt! #roflmao

Hint: mermaids are known to hang around (with) beaches
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: Ariel, Hieupham, Matt-Kenney-google

Understanding SVR - Why don't we call it cure? 7 years 8 months ago #20831

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2. To provide peace of mind to Ariels head


This is a perfectly good reason to do the test.

One question that gets forgotten in medicine is this:

"What do you think it could be?"

I wasn't taught to ask this in medical school, it was a bit of wisdom from a skilled clinician. The significance is that if I don't ask that question, and treat that concern I might get the diagnosis 100% correct, and the treatment 100% correct, but have failed to address the real concern that brought the patient to my door.
YMMV
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Understanding SVR - Why don't we call it cure? 7 years 8 months ago #20834

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This week I have achieved more than in four years since the old tx and I am so grateful to FHC.

That is so awesome to hear because I and many others feel the same way.
Even my short UND, I can think clear, feel energy and know FHC is responsible.
Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
The following user(s) said Thank You: Ariel, Gaj, Hieupham, Greedfighter

Understanding SVR - Why don't we call it cure? 7 years 8 months ago #20837

I feel a tidal wave size splash coming my way!!! Too late for me!!!!! SAVE YERSELVES!!!! :woohoo:
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
The following user(s) said Thank You: Ariel, Gaj

Understanding SVR - Why don't we call it cure? 7 years 8 months ago #20843

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I'm paddling as fast as possible here Matt so it's a tsunami :silly:
Y'know we mermaids and beaches can cause quite a stir haha!
Thankyou for your warm affirmative comments all
I'm done with pathology today and yes I feel lighter for it
Happy splashes from Ariel #flower #flower #flower
Gen 1a
Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas.
pre sof/led VL 240,000 Fibsc F0
Day 25 <30
Day 32 UND
Week 10 UND
EOT UND ALT11AST17GGT19
SVR4 UND ALT10 AST16 GGT13
SVR8 UND ALT <9 AST16 GGT15
SVR12 UND ALT14 AST19 GGT12 Bili 5
EOT +18 ALT13 AST20 GGT9 Bili 5
EOT +21 ALT11AST15
Cured SVR12
Dysplasia Adenomas RemvdAug '16
SVR24 UND ALT11AST16
ColonoscopyClear Nov17
LumpectomyClear ‘18
LithotripsyCytoscopyBiopsy 4/18
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Understanding SVR - Why don't we call it cure? 7 years 8 months ago #20844

That's "swell" (like a gentler tsunami) Ariel :) good thing for me you're feeling lighter .. :lol:
Truly glad to hear it.
My best to you,

Matt
GT1a; Got it some time in the 70's; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA "NOT DETECTED"
AS OF 3/20/2017 ,Hep C RNA PCR "NOT DETECTED" THAT'S SVR24!
The following user(s) said Thank You: Ariel, Gaj

Understanding SVR - Why don't we call it cure? 7 years 7 months ago #20873

Well I'm SVR 16 and I feel like I am 20 again, I just don't look it (55, and a few grey hairs) I feel so good, I will be shocked if I relapse. With these new Sofosbuvir combination treatments, it is a medical breakthrough comparable to the Polio vaccine. Dr. Freeman has said, SVR 12 is 99% and SVR 24 is 99.9%. So get checked at 12, 24 & 52 weeks. After one year, you are officially cured, I have never seen anything indicating a relapse after 52 weeks.
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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Understanding SVR - Why don't we call it cure? 7 years 7 months ago #20878

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GF ... I hear you brother ! This medicine is like a miracle so far, I've never felt so good in three decades ! Awesome post & stay well.
In good health my friend.
Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
The following user(s) said Thank You: Ariel, Greedfighter

Understanding SVR - Why don't we call it cure? 7 years 7 months ago #20900

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:"All hail the new kids"!!!! :) :) Its great to hear so many are feeling youthful again never mind a few grey hairs right? looking forward to the same! ;) Thanks FHC for the chance!
Nadia xxxx
Diagnosed Hep C genotype 1b early 1990's. Treated 1998 peg Interferon/Riba non responder :-(( Meds stopped after 4 or 5 months.
Fibroscan April 2013- 7.3kPa repeated May 2015- 5.8kPa mild scaring
May 2015 ALT 59 AST 56
21/7/2016 ALT 36 AST 44 BIL14
VL 939000
thanks FixhepC +Monkmed started Sof/Led 16/8/2016. :-))
OCT 3 AST33 VL UND
OCT 11 ALT 29 AST 36 VL UND
NOV 10 ALT 27 AST 37 VL UND
JAN 30 2017 ALT 23 AST 29 VL UND
SVR12 ALT 23 AST 27 VL UND!!
SVR 24 UND!!!TY EVERYONE!
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Proxy for viral load test 7 years 6 months ago #21864

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James-Freeman-facebook wrote: Hi A.L.

With the proviso that your ALT was elevated out of range pre treatment (a handful of patients with a significant VL have normal looking LFTs at baseline) then ALT elevation is a reliable marker for relapse. Elevations of LFTs for no obvious reason are the usual reason doctors look for HCV.

So, at SVR24, if your ALT is normal, and you're not feeling any of the "usual suspect pre-treatment symptoms" then HCV RNA PCR is largely academic - we are not going to find anything. My reason for ordering it would be to remove patient doubt/anxiety, rather than because it's strictly needed and I'm not already sure what the result is.


Thanks, Doctor.

That makes sense. I'm not overly concerned, especially as the stats for SVR12 are so well established, but out of curiosity, I might request some LFTs the next time I see my GP. This is a long-term process, so a little more information can't hurt, especially if it is quick and not too draining on the public purse.
G4, F4, cirrhosis.

Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.

YEAR..... ALT..... AST..... GGT... FERRITIN........................................
2009....... 210..... 215..... 953..... 1400........... (Bad health, stupidity)
2015....... 60....... 45....... 150..... 360............. (Improved diet and health, FixHepC treatment)
2016....... 20....... 24....... 25....... 156............. (SVR 12)
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Proxy for viral load test 7 years 6 months ago #21867

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If you're in the US, there are private labs which offer this service.

LFTs are an inexpensive 'out of pocket' test.

Weighing one's health against public largess is usually a no win equation.
Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!

Understanding SVR - Why don't we call it cure? 7 years 6 months ago #21870

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Gaj wrote:

Matt-Kenney-google wrote: You rock beaches


Oh, you're gonna be in so much trouble Matt! #roflmao

Hint: mermaids are known to hang around (with) beaches


lol much

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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