If you're Geno 1a Sof +Led has the best cure rate with Sof + Dac more of a generalised treatment irrespective of reflux problems
Sof+Dac
GT1 ALLY-2 naive (80/83) experienced (43/44) Aggregate 96.8% (123/127)
GT1a ALLY-2 naive 96% (68/71) experienced 97% (32/33) Aggregate 96.2% (100/104)
GT1b ALLY-2 ALLY-2 naive 100% (12/12) experienced 100% (11/11) Aggregate 100% (23/23)
Past Failure ALLY-2 98% (43/44)
Sof+Led
GT1 ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317)
GT1a ION-1 98% (142/145) ION-3 96% 96% (165/172) Aggregate 96.8% (307/317)
GT1b ION-1 100% (67/67) ION-3 98% (43/44) Aggregate 99.1% (110/111)
Past Failure ION-3 94% (102/109)
Not a lot between them, but the data for Sof+Led is more robust due to better n
With F4
Sof+Dac ALLY-2 naive 89% (8/9) experienced 92% (12/13) Aggregate 91% (20/22)
Sof+Led ION-1 97% (32/33)
So although Sof+Led looks better on % basis the entire stats for Sof+Dac and Sof+Led are based on 55 patients, of whom 3 failed.
PPIs prevent Ledipasvir absorption so I would recommend Sof+Dac