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Liver Spots or oxidised iron 6 years 9 months ago #24956
Hi Guys I came across research that connects too much iron may seep into the brain coupled with amyloid plaque leads to onset of Alzheimer. Does anyone know if there has been any research of Hep C people being more susceptible to Alzheimers? thanks The following user(s) said Thank You: DrJames | |
Liver Spots or oxidised iron 6 years 9 months ago #24960
Hi berrinice, There doesn't seem to be much information on Alzheimer's and HCV although I found a 234k patient (insurance) study from Taiwan which compares the incidence of 'dementia' - without directly referencing Alzheimer's. It tracked 117k HCV patients 50 years and older against a 117k randomly picked but age and sex matched non-HCV cohort over ten years from 1999-2009. All patients were determined not to have dementia at commencement of study. They did find enough evidence of a slightly higher incidence developing in the HCV group to state that it "may increase the risk" of dementia. But I don't find this too surprising given what we already know of the long term effects of HCV, including high iron level and many others, on both our physical and mental health as we age. However they also found that having antiviral treatment reduced the risk even in those days with interferon then peginterferon and the low SVR rates in those times. This finding agrees with other more recent studies where we consistently see reaching SVR results in statistically significant improvements in patient health, wellbeing and lifespan. Now that these DAAs with their high cure rate are more accessible, getting treatment as early as possible and reaching SVR is the best way of reducing the risks. PS it must be over a year since your tx now? G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
Liver Spots or oxidised iron 6 years 9 months ago #24961
Liver Spots? Do you mean the brown spots that develop on our hands and elsewhere as we age? If so my layman understanding is that these are due to age and sun rather than iron overload. While iron overload/high ferritin can cause darkening of the skin it is a "bronzing" effect over larger areas. From my reading, SVR reduces HCV caused high ferritin levels but if you have any concerns you could ask your GP to check your levels. G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
Liver Spots or oxidised iron 6 years 9 months ago #24964
Hi Berrinice, Seeing you write about iron levels G2, infected maybe in 1971? Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's. Treatment naive. Fibroscan & bloods all normal ranges. Viral load 7million, began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24 Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage. Kia kaha e hoa ma! The following user(s) said Thank You: Gaj | |
Liver Spots or oxidised iron 6 years 9 months ago #24968
Hi Berrinice, Both spider naevi, and palmar erythema, can in some individuals resolve over time. That is, once the cause of liver damage is removed, as in SVR. So in your case some of those those red bits may still go away. Give it time. Think of it like a nice piece of cheddar cheese, improving with age G2, infected maybe in 1971? Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's. Treatment naive. Fibroscan & bloods all normal ranges. Viral load 7million, began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24 Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage. Kia kaha e hoa ma! | |
Liver Spots or oxidised iron 6 years 9 months ago #24970
Almost all of us (vegans being an exception) take in more iron each day than we need. We have no way to get rid of iron so our bodies regulate the how much is absorbed. The disease haemochromatosis is a genetic condition where patients absorb too much iron and the treatment is bleeding. Unless you have haemochromatosis you body will absorb no more, and no less, than it needs so really the only thing you can do with your diet is reduce the iron in it to such a point that even absorbing 100% your body can't get enough and you will become iron deficient and anaemic. So, in short, there is no benefit in trying to restrict iron intake, and significant downsides if you don't get enough. YMMV | |
Liver Spots or oxidised iron 6 years 6 months ago #25350
Dr Freeman Is this also true with excess Ferritin? I was always told that excess Ferritin was not good for you and inositol or IP6 is one of the only ways to get rid of it, and that takes a lot of time . Thanks Contracted HCV 1980's Geno Type 1a F3 ( doc says once treated I'll be F2 maybe F1) Meds shipped 6/17/2016 arrived early 7/2016 Viral count - 3,471,080 4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected) 8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected) 11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected December 19th 2016: Cured! Viral count: zero!!! 2018 viral count: still zero! Cured! | |
Liver Spots or oxidised iron 6 years 6 months ago #25351
Hi Sven, Ferritin is an acute phase protein so it rises with, for example, any infection. It is also high in many chronic diseases. By itself, it is difficult to interpret. You need to consider it together with the FBC (CBC) and full iron studies. For iron overload, the treatment is venesection (bleeding). Simple, quick, effective and DRUG FREE! YMMV The following user(s) said Thank You: Sven | |
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