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IL28 Explained 8 years 2 months ago #9592
IL28 is a gene. Like most genes you get 1 from mum, and 1 from dad. You can get either a "C" or a "T" IL28 gene from each of your parents. In the days of interferon having "CC" ie 2 copies of the "C" IL28 gene improved your chances of SVR. Two copies of the "T" ie "TT" predicted you would probably fail. As you might expect "CT" or "TC" ie one "C" and one "T" from your parents put you in the middle. With DAAs it's not really important because TT, CT and CC people all do well. It's probably still a little advantageous to have "CC" but there is little point in testing for this these days, and after all, there is nothing you can do about it. YMMV | |
IL28 Explained 8 years 2 months ago #9600
I was wondering about this the other day when you posted the new Decision Support Tool. i.e. For genotypes 2/4/5/6 is there any advantage when making a decision on treatment for the new Australian guidelines that recommend Peg/Riba with Sofosbuvir? Eg "if the patient has TT and maybe CT then follow EASL guidelines and prescribe Sof/Dac" Or would using Sof with the Peg/Riba negate any advantage there? G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The following user(s) said Thank You: Ariel | |
IL28 Explained 8 years 2 months ago #9604
Ah yes and after the tx failed me and popped me into hospital and so on they did my Il28 and I was CT Hmmmmm Thanks to the FixHepC people for my Sof/Led it's changed my life and I haven't even had my first bloods done yet. You have given this liver clinic bench warmer hope and a brighter future Gen 1a Peg/inf/riba 2012(!) stop @ Wk 43 potassium low +issues (rlps week 4 post tx, VL120,000) scnds eg. adenomas. pre sof/led VL 240,000 Fibsc F0 Day 25 <30 Day 32 UND Week 10 UND EOT UND ALT11AST17GGT19 SVR4 UND ALT10 AST16 GGT13 SVR8 UND ALT <9 AST16 GGT15 SVR12 UND ALT14 AST19 GGT12 Bili 5 EOT +18 ALT13 AST20 GGT9 Bili 5 EOT +21 ALT11AST15 Cured SVR12 Dysplasia Adenomas RemvdAug '16 SVR24 UND ALT11AST16 ColonoscopyClear Nov17 LumpectomyClear ‘18 LithotripsyCytoscopyBiopsy 4/18 | |
IL28 Explained 8 years 2 months ago #9683
Hmmm, on further reflection peg/riba is sub optimum for everyone regardless of their genes. While it's reasonably cost achievable to help our mums the best scenario is that PBS doesn't end up discriminating against 9% of HCV infected people to save a few bucks. Anyone know when the final rules get announced? G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND | |
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