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TOPIC: DAAs and Liver Cancer Risk

DAAs and Liver Cancer Risk 3 years 3 months ago #20535

  • Serg
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Hi pat1, no problem :)
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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DAAs and Liver Cancer Risk 3 years 3 months ago #20536

  • Gaj
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Serg wrote:
Another question is possible - if we possibly have initial 7% blip of HCC risks after treatment, then, does it mean that treatment with DAAs with cirrhosis looks like some sort of "Russian roulette" game with 1 "HCC-bullet" per 13 empty chambers?

Only if we wish to be over-melodramatic Serg. Most people would call it a risk-benefit analysis and weigh up the two sides and make a decision that is appropriate for them just like they would with any other medical procedure.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 3 years 3 months ago by Gaj.
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DAAs and Liver Cancer Risk 3 years 3 months ago #20541

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Gaj
Sorry if "russian roulette" analogy seems as some "over-melodramatic" "negative connotation" or something like that. I had read mentioned by you Dr.James's posting with similar analogy and decided that this analogy is ok for this forum.
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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DAAs and Liver Cancer Risk 3 years 3 months ago #20543

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To be clear, I cited the thread not the analogy that was included in a post within it and I made no statements about "negative connotation" or that the analogy should not be used on the forum. I do stand by what I stated.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
Last Edit: 3 years 3 months ago by Gaj.
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DAAs and Liver Cancer Risk 3 years 3 months ago #20545

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Good, no problem. Yes, I agree that usually we need to weigh up two sides.
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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DAAs and Liver Cancer Risk 3 years 3 months ago #20582

  • DrJames
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I like the pack of straws analogy for probability.

I explain 90% as being like pickingfrom a pack of 10 straws. 1 person gets the short one, 9 don't.

When I grew up straws were more common than revolvers and Russian Roulette. The scene from the movie "The deer hunter" put me off that game. Great guitar tune though....
YMMV
Last Edit: 3 years 3 months ago by DrJames.
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DAAs and Liver Cancer Risk 3 years 3 months ago #20587

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Yes, pack of straws is more peaceful analogy... Great movie, great guitar...
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
The administrator has disabled public write access.
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