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DAAs and Liver Cancer Risk 7 years 3 months ago #20535

  • Serg
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Hi pat1, no problem :)
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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DAAs and Liver Cancer Risk 7 years 3 months ago #20536

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Serg wrote: Another question is possible - if we possibly have initial 7% blip of HCC risks after treatment, then, does it mean that treatment with DAAs with cirrhosis looks like some sort of "Russian roulette" game with 1 "HCC-bullet" per 13 empty chambers?


Only if we wish to be over-melodramatic Serg. Most people would call it a risk-benefit analysis and weigh up the two sides and make a decision that is appropriate for them just like they would with any other medical procedure.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: pat1, fitz

DAAs and Liver Cancer Risk 7 years 3 months ago #20541

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Gaj
Sorry if "russian roulette" analogy seems as some "over-melodramatic" "negative connotation" or something like that. I had read mentioned by you Dr.James's posting with similar analogy and decided that this analogy is ok for this forum.
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
The following user(s) said Thank You: pat1

DAAs and Liver Cancer Risk 7 years 3 months ago #20543

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To be clear, I cited the thread not the analogy that was included in a post within it and I made no statements about "negative connotation" or that the analogy should not be used on the forum. I do stand by what I stated.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
The following user(s) said Thank You: pat1, fitz

DAAs and Liver Cancer Risk 7 years 3 months ago #20545

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Good, no problem. Yes, I agree that usually we need to weigh up two sides.
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
The following user(s) said Thank You: pat1

DAAs and Liver Cancer Risk 7 years 3 months ago #20582

  • DrJames
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I like the pack of straws analogy for probability.

I explain 90% as being like pickingfrom a pack of 10 straws. 1 person gets the short one, 9 don't.

When I grew up straws were more common than revolvers and Russian Roulette. The scene from the movie "The deer hunter" put me off that game. Great guitar tune though....

YMMV
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DAAs and Liver Cancer Risk 7 years 3 months ago #20587

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Yes, pack of straws is more peaceful analogy... Great movie, great guitar...
Probably infected in 1977
2005 - diagnosed with HCV 1b, compensated F4, 15 mln viral load, ALT 320
2005-2006 - PegIFN/rib 48 weeks treatment, relapse
2016 - compensated F4, MELD 8-9, ALT 100-160
2018 - compensated F4, MELD 8, ALT 91
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