TOPIC:

Good luck with it this time round mate.

Too right everything that's been said and my support too add it in too Splitdog I am backing you go for it until those buggers have Buggered off
I'm certain you are charged gladiator style and full on for the conquering ahead
Go Splidog
Love and support from Ariel

This is it Splitdog, you're gonna win

Sofosvel came today from Beacon. Dr. Freeman recommended I wait until Voxilaprevir becomes available for the triple-cocktail treatment. It will be hard, but I will wait. I recently had a fibroScan test done and I just entered into F3. The shipment from Beacon went smooth as silk. I got a script from Dr. Freeman, which he forwarded to Beacon, then the bank transfer. That was all that was required. It came to the US in 3 days.

Good luck Splitdog although luck isn't even enough I want to say more than just luck it sounds glib and I'm trying to tell you how great this is and thank you for posting the picture and affirming the process.
I love the chillis and glass cleaner and a texas something bottle in the pic what combo was that hahaha (jokes)
This step forward must have helped you feel more confident great to read real stuff real treatment stories and the more testing times should be shared I believe
Backing you Splitdog for cure. Thanks again for the post it will surely give others hope
Sending love
Ariel

So Voxilaprevir is the mysterious GS-9857 which is a Ns3 protease inhibitor like simeprevir I think when is it due out ? I hope it works out for you this time Splitdog.

Cheers

Yes, GS-9857. I don't want to hex anything, but the triple combo I believe gave 99% with type 3 previous DAA failures. The first results from phase III trials will be available in January.
Thank you, Paul.

Thank you, Ariel. I grow and eat exotic chiles. If I'm not sweating, it ain't hot enough!

Go get 'em, Split!
99%.
I like it!
m

Should we start a new thread titled 'Vox"?

I found this today:
In summary, administration of multiple doses of GS-9857 was well tolerated and resulted in a robust decline of HCV RNA levels in patients with genotype 1–4 HCV infection. Notably, the potent antiviral activity of GS-9857 was preserved in the presence of commonly observed NS3 mutations associated with resistance to protease inhibitors. GS-9857 demonstrated linear PK when administered at doses ranging from 50 to 300 mg under fasting conditions. The median half-life of GS-9857 ranged from 29 to 42 h, conducive to once-daily dosing. Lastly, GS-9857 has demonstrated additive antiviral activity when evaluated in vitro in combination with sofosbuvir or velpatasvir.[5] Together, these data support the further development of once-daily GS-9857 in combination with other DAAs for the treatment of patients with chronic HCV infection.

Awesome pic Splitdog. Best wishes from me for treatment with these new meds. It was was interesting to read the data that you have put up as well. Beacon came through and so all in all very encouraging news. you have the very best support team in the world with you

Thank you Pat and Mike. I can't wait to wage war on these bastards!!!

Ha! Split you can eat those chillies for me! Between Mike with his garlic cloves in Transylvania and you with your chilies you have my food intolerances I have deeveloped post old tx sorted. These two things I now simply cannot eat! No more chilli no more garlic! Once was a lover of both, now my tummy says NO!
I loved you photo.
Have a great spicy flavoured day Splitdog, Happies from Ariel

splitdog wrote: Should we start a new thread titled 'Vox"?

Done, click on link below.

fixhepc.com/forum/relapse-corner/1263-vo...tease-inhibitor.html

Vox works best for retreatment. It has gastrointestinal side effects, however it is effective for previous sof failures.
Vel is not very effective for previous sof relapsers, but is recommended for treatment-naive people, because it has no vox-related side effects.