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Autoimmune and Harvoni 5 years 3 months ago #27545
Has anyone treated with DAAs who also has an autoimmune condition like rheumatoid arthritis or lupus or another one? What was the outcome? Any flares of autoimmune during DAA treatment? Can Dr Freeman also comment on his experience with this? The following user(s) said Thank You: Mar | |
Autoimmune and Harvoni 5 years 3 months ago #27546
Hello Penn, There is quiet a strong association between autoimmunity and Hepatitis C. The immune-related extrahepatic manifestations include:
This article speaks to your questions rmdopen.bmj.com/content/1/1/e000008 with the answer "we just don't know". This article says "use DMARDs with caution in HCV" www.eurjrheumatol.org/sayilar/211/buyuk/194-9.pdf This article suggests slightly lower SVR rates in patients with autoimmunity bmjopengastro.bmj.com/content/5/1/e000203 There is a tiny 3 case series here bmcgastroenterol.biomedcentral.com/artic...86/s12876-018-0826-7 showing a transient fall in autoantibodies during treatment But in terms of a study that said something like "patients with HCV and autoimmunity have reduced autoimmunity on and after HCV treatment" - as far as I know nobody has done a large trial to answer that one way or another. It sounds like you are weighing up treatment options? YMMV | |
Autoimmune and Harvoni 5 years 3 months ago #27549
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Hey. Thank you very much. This information helped me a lot. I thought I would create a topic. Good luck! |
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